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Deficiency of ZFP36L1 and ZFP36L2 impairs liver homeostasis and initiates cholestatic liver injury. [PDF]

Hepatol Commun
Kumar R, Blackshear PJ, Patial S, Saini Y.   +3 more
europepmc   +1 more source

Chasing the ghost in the code: highlighting the mystery of a rare genetic condition. [PDF]

Am J Physiol Cell Physiol
Delpire E.
europepmc   +1 more source

The WNK-OXSR1 osmosensing pathway mediates intestinal regeneration via Hippo-YAP signaling. [PDF]

EMBO J
Cao H, Huang X, Jiang X, Deng J, Wang J, Wu C, Hu M, Zeng B, Hu Z, Pan H, Yang Y, Zheng K, Shen R, Zhang M, Liu B.   +14 more
europepmc   +1 more source

Irgm1 Restrains CD8⁺ T Cell Cytokine Production and Apoptosis via Cell-Extrinsic Regulation of Type I Interferon Signaling. [PDF]

Eur J Immunol
Molloy CT, Alwarawrah Y, Cohen JA, Fee BE, Whitmire JK, Taylor GA, MacIver NJ.   +6 more
europepmc   +1 more source

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Xpaknockout mice

Seminars in Cancer Biology, 1996
The xeroderma pigmentosum group A correcting (XPA) gene encodes a DNA binding zinc-finger protein that recognizes DNA damage. As such the XPA protein participates in the initial step of the process of nucleotide excision repair. The multicomponent nucleotide excision repair pathway is one of the most thoroughly studied mechanisms that defends both ...
de Vries, A, van Steeg, H
openaire   +3 more sources

Xenobiotic receptor knockout mice

Toxicology Letters, 1995
Administration of certain foreign chemicals to animals elicits responses that are due to receptor-mediated activation of gene expression. Among the most well studied receptors are the Ah receptor (AHR) that binds 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds and the peroxisome proliferator-activated receptors, PPARs, that mediate gene ...
F J, Gonzalez, P, Fernandez-Salguero, S S, Lee, T, Pineau, J M, Ward   +4 more
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Insulin Receptor Knockout Mice

Annual Review of Physiology, 2003
▪ Abstract  To examine the role of the insulin receptor in fuel homeostasis, we and others have carried out genetic ablation studies in mice. Mice lacking insulin receptors are born with normal features, but develop early postnatal diabetes and die of ketoacidosis.
Tadahiro, Kitamura, C Ronald, Kahn, Domenico, Accili   +2 more
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Generating Conditional Knockout Mice

2010
Gene targeting in ES cells is extensively used to generate designed mouse mutants and to study gene function in vivo. Knockout mice that harbor a null allele in their germline provide appropriate genetic models of inherited diseases and often exhibit embryonic or early postnatal lethality. To study gene function in adult mice and in selected cell types,
Roland H, Friedel, Wolfgang, Wurst, Benedikt, Wefers, Ralf, Kühn   +3 more
openaire   +2 more sources