Results 291 to 300 of about 2,431,068 (346)

Lessons from CRH knockout mice

Neuropeptides, 2002
Corticotropin-releasing hormone (CRH), the major regulator of hypothalamic-pituitary-adrenal (HPA) axis, has a wide spectrum of actions within the central nervous system and the periphery. The development and use of Crh knockout mice (Crh-/-) has been an important tool for addressing the physiologic and pathologic roles of CRH.
M, Venihaki, J, Majzoub
openaire   +2 more sources

Generation of dynorphin knockout mice

Molecular Brain Research, 2001
The opioid system has important roles in controlling pain, reward and addiction, and is implicated in numerous other processes within and outside the nervous system, such as mood states, immune responses, and prenatal developmental processes. The effects of the opioid system are mediated by at least three ligands, enkephalin, endorphin, and dynorphin ...
N, Sharifi, N, Diehl, L, Yaswen, M B, Brennan, U, Hochgeschwender   +4 more
openaire   +2 more sources

Estrogen Receptor-α Knockout Mice

2016
Tissue specific knockout mice are valuable tools to study gene function in vivo. The method uses the Cre/loxP system in which loxP sites are cloned into the genome surrounding one or more exons of a gene and the targeted exon(s) are deleted when the Cre enzyme is expressed. Mouse lines that are prepared for the generation of knockout ERα mice have been
Per, Antonson, Patricia, Humire, Jan-Åke, Gustafsson   +2 more
openaire   +2 more sources

[Adiponectin knockout mice].

Nihon rinsho. Japanese journal of clinical medicine, 2004
Here we investigated the biological functions of adiponectin, a fat-derived hormone, by disrupting the gene encodes it in mice. Adiponectin knockout mice (KO) exhibited severe diet-induced insulin resistance with reduced IRS-1-associated P13-kinase activity in muscle.
Norikazu, Maeda, Tohru, Funahashi
openaire   +1 more source

Generation of Conditional Knockout Mice

2014
Conditional knockout mouse models are powerful tools to examine the biological and molecular function(s) of genes in specific tissues. The general procedure to generate such genetically engineered mouse models consists of three main steps. The first step is to find the appropriate genomic clone of the gene of interest and to design the cloning and ...
Kazuhito, Sakamoto, Channabasavaiah B, Gurumurthy, Kay-Uwe, Wagner   +2 more
openaire   +2 more sources

Knockout Mice

New England Journal of Medicine, 1996
J A, Majzoub, L J, Muglia
openaire   +2 more sources

Knockout Mice

2006
  +5 more sources

P.2.b.019 Behavioural characterization of mice knockout for the nociceptin/orphanin FQ receptor gene in animal models of anxiety

European Neuropsychopharmacology, 2006
E. Gavioli, G. Marzola, G. Calo’
semanticscholar   +1 more source

Generation of knockout mice by Cpf1-mediated gene targeting

Nature Biotechnology, 2016
Yongsub Kim, Seung-A. Cheong, Jong Geol Lee, Sang-Wook Lee, Myeong Sup Lee, In-Jeoung Baek, Y. Sung   +6 more
semanticscholar   +1 more source

Conditional Knockout Mice

2003
Ralf, Kühn, Frieder, Schwenk
openaire   +2 more sources