Analysis of microRNA knockouts in mice [PDF]
Human Molecular Genetics, 2010 MicroRNAs (miRNAs) are small noncoding RNAs that act as potent regulators of gene expression. The discovery of miRNAs with specific temporal and spatial expression patterns revealed a hidden layer of post-transcriptional gene regulation. Furthermore, differential expression of miRNAs during disease progression identified miRNAs as relevant candidate ...
Michael T. McManus +2 more
openaire +3 more sources
Fixing Knockout Tournaments With Seeds [PDF]
Discrete Applied Mathematics, 339:21-35 (2023), 2022 Knockout tournaments constitute a popular format for organizing sports competitions. While prior results have shown that it is often possible to manipulate a knockout tournament by fixing the bracket, these results ignore the prevalent aspect of player seeds, which can significantly constrain the chosen bracket.
arxiv +1 more source
The effect of lubricin on the gliding resistance of mouse intrasynovial tendon.
PLoS ONE, 2013 The purpose of this study was to investigate the role of lubricin on the gliding resistance of intrasynovial tendons by comparing lubricin knockout, heterozygous, and wild type mice.
Masanori Hayashi +6 more
doaj +1 more source
Vascular smooth muscle Sirtuin-1 protects against aortic dissection during Angiotensin II-induced hypertension [PDF]
, 2015 BACKGROUND: Sirtuin-1 (SirT1), a nicotinamide adenine dinucleotide(+)-dependent deacetylase, is a key enzyme in the cellular response to metabolic, inflammatory, and oxidative stresses; however, the role of endogenous SirT1 in the vasculature has not ...
Akiki, Rachid +10 more
core +1 more source
The NMDA receptor GluN2C subunit controls cortical excitatoryinhibitory balance, neuronal oscillations and cognitive function [PDF]
, 2016 Despite strong evidence for NMDA receptor (NMDAR) hypofunction as an underlying factor for cognitive disorders, the precise roles of various NMDAR subtypes remains unknown.
Dravid, Shashank M. +11 more
core +3 more sources
Bayesian latent hierarchical model for transcriptomic meta-analysis to detect biomarkers with clustered meta-patterns of differential expression signals [PDF]
Ann Appl Stat. 2019 Mar 13(1), 2017 Due to the rapid development of high-throughput experimental techniques and fast-dropping prices, many transcriptomic datasets have been generated and accumulated in the public domain. Meta-analysis combining multiple transcriptomic studies can increase the statistical power to detect disease-related biomarkers.
arxiv +1 more source
Vasculitis, Atherosclerosis, and Altered HDL Composition in Heme-Oxygenase-1-Knockout Mice
International Journal of Hypertension, 2012 To elucidate roles of heme oxygenase-1 (HO-1) in cardiovascular system, we have analyzed one-year-old HO-1-knockout mice. Homozygous HO-1-knockout mice had severe aortitis and coronary arteritis with mononuclear cellular infiltration and fatty streak ...
Kazunobu Ishikawa +2 more
doaj +1 more source
Myotubularin MTM1 Involved in Centronuclear Myopathy and its Roles in Human and Yeast Cells [PDF]
Journal of Molecular and Genetic Medicine, OMICS International,
2015, 08 (02), 2018 Mutations in the MTM1 gene, encoding the phosphoinositide phosphatase myotubularin, are responsible for the X-linked centronuclear myopathy (XLCNM) or X-linked myotubular myopathy (XLMTM). The MTM1 gene was first identified in 1996 and its function as a PtdIns3P and PtdIns(,5)P2 phosphatase was discovered in 2000.
arxiv +1 more source
Rab11a is required for apical protein localisation in the intestine
Biology Open, 2014 The small GTPase Rab11 plays an important role in the recycling of proteins to the plasma membrane as well as in polarised transport in epithelial cells and neurons. We generated conditional knockout mice deficient in Rab11a.
Tomoaki Sobajima +10 more
doaj +1 more source
Reduced axonal diameter of peripheral nerve fibres in a mouse model of Rett syndrome [PDF]
, 2017 Rett syndrome (RTT) is a neurological disorder characterized by motor and cognitive impairment, autonomic dysfunction and a loss of purposeful hand skills.
Bahey, Noha G. +5 more
core +1 more source