Results 31 to 40 of about 428,092 (271)
Endothelial Cell-specific Loss of Breast Cancer Susceptibility Gene 2 Exacerbates Atherosclerosis [PDF]
arXiv, 2023 The BReast CAncer type 2 susceptibility protein (BRCA2) responds to DNA damage by participating in homology-directed repair. BRCA2 deficiency culminates in defective DNA damage repair (DDR) that when prolonged leads to the accumulation of DNA damage causing cancer or apoptosis.
arxiv
Effect of the social environment on olfaction and social skills in WT and mouse model of autism [PDF]
arXiv, 2023 Autism spectrum disorders are complex, polygenic and heterogenous neurodevelopmental conditions, imposing a substantial economic burden. Genetics are influenced by the environment, specifically the social experience during the critical neurodevelopmental period.
arxiv
Transgenic mice: beyond the knockout [PDF]
American Journal of Physiology-Renal Physiology, 2011 Transgenic mice have had a tremendous impact on biomedical research. Most researchers are familiar with transgenic mice that carry Cre recombinase (Cre) and how they are used to create conditional knockouts. However, some researchers are less familiar with many of the other types of transgenic mice and their applications.
openaire +3 more sources
Knockout mice as experimental models of virulence [PDF]
Medical Mycology, 2000 Infection models with animals whose immune systems have been selectively altered by neutralization of endogenous cytokines or by deletion of a gene have provided a valuable means to study the function of cells or cytokines in the context of complex multidimensional interactions.
DEEPE G. S. J.R. +6 more
openaire +4 more sources
The roles of P2Y2 purinergic receptors in osteoblasts and mechanotransduction. [PDF]
PLoS ONE, 2014 We previously demonstrated, using osteoblastic MC3T3-E1 cells, that P2Y2 purinergic receptors are involved in osteoblast mechanotransduction. In this study, our objective was to further investigate, using a knockout mouse model, the roles of P2Y2 ...
Yanghui Xing +5 more
doaj +1 more source
mGluR5 Knockout mice exhibit normal conditioned place-preference to cocaine [PDF]
, 2012 Metabotropic glutamate receptor 5 (mGluR5) null mutant (-/-) mice have been reported to totally lack the rein- forcing or locomotor stimulating effects of cocaine. We tested mGluR5 -/- and +/+ mice for their locomotor and conditioned place- preference response to cocaine.
arxiv +1 more source
Effective polarization in proton-induced $α$ knockout reactions [PDF]
, 2022 The effective polarization of the residual nucleus in the proton-induced $\alpha$ knockout reaction is investigated within the distorted wave impulse approximation framework. The strong absorption of the emitted $\alpha$ particle results in strong selectivity on the reaction "position" depending on the third component of the single-particle orbital ...
arxiv +1 more source
PLoS ONE, 2020 Aryl hydrocarbon receptor (AHR) agonists such as dioxin have been associated with obesity and the development of diabetes. Whole-body Ahr knockout mice on high-fat diet (HFD) have been shown to resist obesity and hepatic steatosis.
Francoise A Gourronc +9 more
doaj +1 more source
Antioxidants, 2022 Selenoprotein F (SELENOF) might play an important role in maintaining human health since an increasing number of studies have linked SELENOF deficiency to various pathologies such as cancer and neurodegeneration.
Min Li, Yun Zhang, Jun Zhou, Hongmei Liu
doaj +1 more source
ODBAE: a high-performance model identifying complex phenotypes in high-dimensional biological datasets [PDF]
arXiv, 2022 Identifying complex phenotypes from high-dimensional biological data is challenging due to the intricate interdependencies among different physiological indicators. Traditional approaches often focus on detecting outliers in single variables, overlooking the broader network of interactions that contribute to phenotype emergence.
arxiv