Results 41 to 50 of about 565,375 (311)

Noninvasive, In Vivo Assessment of Mouse Retinal Structure Using Optical Coherence Tomography [PDF]

, 2009
BACKGROUND: Optical coherence tomography (OCT) is a novel method of retinal in vivo imaging. In this study, we assessed the potential of OCT to yield histology-analogue sections in mouse models of retinal degeneration.
Gesine Huber, Huber, G., Muehlfriedel, Regine, Edda Fahl, Jan Wijnholds, Beck, SC, Remé Charlotte E., Tanimoto, Naoyuki, Tanimoto Naoyuki, Pacal, M, Van de Pavert, S.A., Fischer M. Dominik, Fischer, M.D., Pacal Marek, Christian Grimm, Muehlfriedel Regine, Wenzel, Andreas, Charlotte E Remé, Charlotte E. Remé, Pacal, Marek, Serge A van de Pavert, M. Dominik Fischer, Rod Bremner, Wenzel, A., Bremner Rod, Remé, Charlotte E, Fischer, M Dominik, Susanne C. Beck, Huber, Gesine, Wijnholds, J, Fahl, E, Beck, S.C., Marek Pacal, Grimm Christian, Wenzel, A, Regine Muehlfriedel, Huber Gesine, Wijnholds, Jan, Tanimoto, N, Bremner, R., Reme, C.E., Wijnholds, Jan; https://orcid.org/, Bremner, R, Seeliger Mathias W., Beck, Susanne C., Fischer, M. Dominik, Mathias W Seeliger, Wijnholds Jan, Bremner, Rod, van de Pavert Serge A., M Dominik Fischer, Andreas Wenzel, Mühlfriedel, Regine, Tanimoto, N., Fahl, E., Seeliger, Mathias W, Fischer, Manuel, Beck Susanne C., Seeliger, Mathias W., Remé, Charlotte E., Van De Pavert, SA, Fahl, Edda, Pacal, M., Remé, CE, van de Pavert, Serge A., Beck, Susanne C; https://orcid.org/, Huber, G, Grimm, C., Seeliger, MW, Wenzel Andreas, Fahl Edda, Mathias W. Seeliger, Pavert, S.A. van de, Grimm, C, Grimm, Christian, Grimm, Christian; https://orcid.org/, Muehlfriedel, R., Serge A. Van De Pavert¤b, Wijnholds, J., van de Pavert, Serge A, Susanne C Beck, Fischer, MD, Muehlfriedel, R, Seeliger, M.W., Naoyuki Tanimoto   +84 more
core   +1 more source

Ovol2, a zinc finger transcription factor, is dispensable for spermatogenesis in mice

Reproductive Biology and Endocrinology, 2019
Ovol2, a mouse homolog of Drosophila ovo, was identified as a zinc finger transcription factor predominantly expressed in testis. However, the function of Ovol2 in postnatal male germ cell development remains enigmatic. Here, we firstly examined the mRNA
Jin Zhang, Juan Dong, Weibing Qin, Congcong Cao, Yujiao Wen, Yunge Tang, Shuiqiao Yuan   +6 more
doaj   +1 more source

Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice [PDF]

, 2013
International efforts to test gene function in the mouse by the systematic knockout of each gene are creating many lines in which embryonic development is compromised.
Mohun, Timothy, Richard Baldock, Andrew J. Copp, Houart, Corinne, Hurles, Matt E., Hemberger, Myriam, Wolfgang Weninger, James C. Smith, Adams, David J, Shoumo Bhattacharya, Bhattacharya, Shoumo, Corinne Houart, Hurles, Matt E, Weninger, W, Weninger, Wolfgang, Timothy Mohun, Tom Weaver, Adams, David J., Smith, James C., Baldock, Richard, Weaver, T, David J. Adams, Adams, DJ, Houart, C, Baldock, R, Mohun, T, Hemberger, M, Copp, Andrew J., Weaver, Tom, Bhattacharya, S, Smith, JC, Elizabeth Robertson, Robertson, E, Copp, Andrew J, Myriam Hemberger, Copp, AJ, Robertson, Elizabeth, Hurles, ME, Matt E. Hurles   +38 more
core   +1 more source

Selenoprotein F Knockout Caused Glucose Metabolism Disorder in Young Mice by Disrupting Redox Homeostasis

Antioxidants, 2022
Selenoprotein F (SELENOF) might play an important role in maintaining human health since an increasing number of studies have linked SELENOF deficiency to various pathologies such as cancer and neurodegeneration.
Min Li, Yun Zhang, Jun Zhou, Hongmei Liu
doaj   +1 more source

Prolactin delays hair regrowth in mice

, 2006
Mammalian hair growth is cyclic, with hair-producing follicles alternating between active (anagen) and quiescent (telogen) phases. The timing of hair cycles is advanced in prolactin receptor (PRLR) knockout mice, suggesting that prolactin has a role in ...
Ashby, M.G., Nixon, A.J., Pearson, A.J., Ormandy, C.J., Blazek, K., Wilkins, Richard J., Craven, A.J.   +6 more
core   +1 more source

Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors [PDF]

, 2010
Follicle stimulating hormone (FSH) and androgen act to stimulate and maintain spermatogenesis. FSH acts directly on the Sertoli cells to stimulate germ cell number and acts indirectly to increase androgen production by the Leydig cells.
Abel, M.H., Verhoeven, G., De Gendt, K., Monteiro, A., O'Shaughnessy, P.J.   +4 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Lack of Inducible Nitric Oxide Synthase Prevents Lipid-Induced Skeletal Muscle Insulin Resistance Without Attenuating Cytokine Level

Journal of Pharmacological Sciences, 2011
.: We examined whether deletion of inducible nitric oxide synthase (iNOS) could prevent lipid infusion-induced insulin resistance in iNOS-knockout and wild-type mice with the in vivo euglycemic-hyperinsulinemic clamp technique. Plasma NO metabolites were
Hye-Na Cha, Seung Eun Song, Yong-Woon Kim, Jong-Yeon Kim, Kyu-Chang Won, So-Young Park   +5 more
doaj   +1 more source

The NADPH Oxidase Isoform 1 Contributes to Angiotensin II-Mediated DNA Damage in the Kidney

Antioxidants, 2020
In higher concentrations, the blood pressure regulating hormone angiotensin II leads to vasoconstriction, hypertension, and oxidative stress by activating NADPH oxidases which are a major enzymatic source of reactive oxygen species (ROS).
Anna Zimnol, Nora Spicker, Ronja Balhorn, Katrin Schröder, Nicole Schupp   +4 more
doaj   +1 more source

Transcriptional Profiling of Luteinizing Hormone Receptor-Deficient Mice Before and after Testosterone Treatment Provides Insight into the Hormonal Control of Postnatal Testicular Development and Leydig Cell Differentiation [PDF]

, 2010
Luteinizing hormone (LH) is a key regulator of male fertility through its effects on testosterone secretion by Leydig cells. Transcriptional control of this is, however, currently poorly understood.
Affara, Nabeel, Abel, M, Ellis, Peter J.I., Dunmore, B., Bauer, Johann W., Griffin, Darren K.   +5 more
core   +1 more source