Results 31 to 40 of about 565,375 (311)
Neural Plasticity, 2023 Several microRNAs (miRNAs), including miR-23 and miR-27a have been reportedly involved in regulating myelination in the central nervous system. Although miR-23 and miR-27a form clusters in vivo and the clustered miRNAs are known to perform complementary ...
Yuji Tsuchikawa +8 more
doaj +1 more source
Integrins in vascular development
Brazilian Journal of Medical and Biological Research, 1999 Many growth factors and their protein kinase receptors play a role in regulating vascular development. In addition, cell adhesion molecules, such as integrins and their ligands in the extracellular matrix, play important roles in the adhesion, migration,
R.O. Hynes +2 more
doaj +1 more source
Establishment and identification of a mouse model of Fscb/Cabyr double gene knockout
Di-san junyi daxue xuebao, 2020 Objective To construct a mouse model of targeted knockout of Fscb/Cabyr dual genes by using the CRISPR/Cas9 system, in order to found a basis for the study of the role of FSCB and CABYR protein complexe in sperm flagellum movement and capacitation ...
LI Zhongtai +3 more
doaj +1 more source
Dental and periodontal phenotype in sclerostin knockout mice. [PDF]
, 2014 Sclerostin is a Wnt signalling antagonist that controls bone metabolism. Sclerostin is expressed by osteocytes and cementocytes; however, its role in the formation of dental structures remains unclear.
Heimel, Patrick +15 more
core +1 more source
Transforming growth factor-ß (TGF-ß) signaling in hematopoiesis and tumorigenesis [PDF]
, 2008 Transforming growth factor β (TGF-β) signaling regulates numerous cellular and physiological processes. Dysfunction of components of this signaling pathway leads to a wide range of diseases ranging from malignant hematopoiesis, cardiovascular disease,
Pan, Dejing
core +1 more source
Adenine-Induced Nephropathy Reduces Atherosclerosis in ApoE Knockout Mice [PDF]
, 2022 Background: Cardiovascular events are the main cause of death in patients with chronic kidney disease. We hypothesize that the protective effects of renal cholesterol and vitamin D(3) metabolism are lost under this condition.
Verouti, Sofia N. +10 more
core +1 more source
Mu-opioid receptor knockout mice show diminished food-anticipatory activity
, 2004 We have previously suggested that during or prior to activation of anticipatory behaviour to a coming reward, mu-opioid receptors are activated. To test this hypothesis schedule induced food-anticipatory activity in mu-opioid receptor knockout mice was ...
van den Bos, Ruud +11 more
core +1 more source
The roles of P2Y2 purinergic receptors in osteoblasts and mechanotransduction. [PDF]
PLoS ONE, 2014 We previously demonstrated, using osteoblastic MC3T3-E1 cells, that P2Y2 purinergic receptors are involved in osteoblast mechanotransduction. In this study, our objective was to further investigate, using a knockout mouse model, the roles of P2Y2 ...
Yanghui Xing +5 more
doaj +1 more source
Biology, 2022 AM knockout (AM-/-) and RAMP2 knockout (RAMP2-/-) proved lethal for mice due to impaired embryonic vascular development. Although most vascular endothelial cell-specific RAMP2 knockout (E-RAMP2-/-) mice also died during the perinatal period, a few E ...
Takayuki Shindo +5 more
doaj +1 more source
Generation and Characterization of Rac3 Knockout Mice [PDF]
Molecular and Cellular Biology, 2005 Rac proteins are members of the Rho family of GTPases involved in the regulation of actin dynamics. The three highly homologous Rac proteins in mammals are the ubiquitous Rac1, the hematopoiesis-specific Rac2, and the least-characterized Rac3. We show here that Rac3 mRNA is widely and specifically expressed in the developing nervous system, with ...
Corbetta S +6 more
openaire +3 more sources