Investigation into the role of annexin 1 in the microcirculation of annexin 1 knockout mice [PDF]
, 2005 PhDGlucocorticoids are used therapeutically for their anti-inflammatory and immunosuppressive actions. One of the ways they produce their potent effects is via regulation of the anti-inflammatory protein Annexin I (ANX-AI; 37 kDa protein).
Chatterjee, Bristi Emma
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Altered reward circuitry in the norepinephrine transporter knockout mouse. [PDF]
PLoS ONE, 2013 Synaptic levels of the monoamine neurotransmitters dopamine, serotonin, and norepinephrine are modulated by their respective plasma membrane transporters, albeit with a few exceptions.
Joseph J Gallagher +5 more
doaj +1 more source
Frontiers in Physiology, 2023 High levels of low density lipoprotein (LDL) cholesterol and low levels of high density lipoprotein (HDL) cholesterol are risk factors for cardiovascular disease. Mice that lack genes involved in the clearance of LDL from the bloodstream, such as the LDL
Mark T. Fuller +15 more
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Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis. [PDF]
, 2002 As a resident of early endosomal phagosomes, Mycobacterium tuberculosis is connected to the iron uptake system of the host macrophage. beta-2-microglobulin (beta2m) knockout (KO) mice are more susceptible to tuberculosis than wild-type mice, which is ...
Friedrich Priem +11 more
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Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes. [PDF]
PLoS ONE, 2015 The genetic targeting of mouse models has given insight into complex processes. However, phenotypes of genetically targeted mice are susceptible to artifacts due to gene manipulation, which may lead to misinterpretation of the observations.
Outi Sareila +4 more
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Mu-opioid receptor knockout mice show diminished food-anticipatory activity [PDF]
, 2004 We have previously suggested that during or prior to activation of anticipatory behaviour to a coming reward, mu-opioid receptors are activated. To test this hypothesis schedule induced food-anticipatory activity in mu-opioid receptor knockout mice was ...
van den Bos, Ruud +11 more
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The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system [PDF]
, 2008 INTRODUCTION: Ghrelin and cannabinoids stimulate appetite, this effect possibly being mediated by the activation of hypothalamic AMP-activated protein kinase (AMPK), a key enzyme in appetite and metabolism regulation. The cannabinoid receptor type 1 (CB1)
Judith Harvey-White +59 more
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Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice. [PDF]
, 2010 In a variety of organisms, including mammals, caloric restriction improves metabolic status and lowers the incidence of chronic-degenerative diseases, ultimately leading to increased lifespan.
Soppo, Charlotte Blanche Ekalle +114 more
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Knockout Corner: Knockout mice for monoamine oxidase A [PDF]
The International Journal of Neuropsychopharmacology, 1999 A line of transgenic mice was isolated in which transgene integration had caused a deletion in the gene encoding monoamine oxidase A, an enzyme that degrades serotonin and norepinephrine. This has provided an animal model of MAOA deficiency in humans, a condition characterized by borderline mental retardation and impulsive aggression.
Isabelle, Seif, Edward, De Maeyer
openaire +2 more sources
Arquivos de Neuro-Psiquiatria, 2009 The aim of this study was to evaluate the role of connexin 32 (Cx 32) during remyelination of the peripheral nervous system, through a local injection of either 0,1% ethidium bromide solution or saline in the sciatic nerve of Cx 32 knockout mice ...
Adriano Tony Ramos +10 more
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