Results 41 to 50 of about 1,644,764 (242)

The roles of P2Y2 purinergic receptors in osteoblasts and mechanotransduction. [PDF]

PLoS ONE, 2014
We previously demonstrated, using osteoblastic MC3T3-E1 cells, that P2Y2 purinergic receptors are involved in osteoblast mechanotransduction. In this study, our objective was to further investigate, using a knockout mouse model, the roles of P2Y2 ...
Yanghui Xing, Yan Gu, James J Bresnahan, Emmanuel M Paul, Henry J Donahue, Jun You   +5 more
doaj   +1 more source

Double Deletion of Angiotensin II Type 2 and Mas Receptors Accelerates Aging‐Related Muscle Weakness in Male Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background The activation of AT2 (angiotensin II type 2 receptor ) and Mas receptor by angiotensin II and angiotensin‐(1‐7), respectively, is the primary process that counteracts activation of the canonical renin‐angiotensin system (RAS).
Hikari Takeshita, Koichi Yamamoto, Masaki Mogi, Yu Wang, Yoichi Nozato, Taku Fujimoto, Serina Yokoyama, Kazuhiro Hongyo, Futoshi Nakagami, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Masatsugu Horiuchi, Hiromi Rakugi   +14 more
doaj   +1 more source

Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.

Journal of Clinical Investigation, 1997
Monocyte chemoattractant protein-1 (MCP-1) is a potent agonist for mononuclear leukocytes and has been implicated in the pathogenesis of atherosclerosis and granulomatous lung disease. To determine the role of MCP-1 and related family members in vivo, we
L. Boring, J. Gosling, S. Chensue, S. Kunkel, Robert V Farese, H. Broxmeyer, I. Charo   +6 more
semanticscholar   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice.

Proceedings of the National Academy of Sciences of the United States of America, 1999
Delta9-Tetrahydrocannabinol (Delta9-THC), the major psychoactive ingredient in preparations of Cannabis sativa (marijuana, hashish), elicits central nervous system (CNS) responses, including cognitive alterations and euphoria. These responses account for
A. Zimmer, A. Zimmer, A. Hohmann, M. Herkenham, T. Bonner   +4 more
semanticscholar   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

The NADPH Oxidase Isoform 1 Contributes to Angiotensin II-Mediated DNA Damage in the Kidney

Antioxidants, 2020
In higher concentrations, the blood pressure regulating hormone angiotensin II leads to vasoconstriction, hypertension, and oxidative stress by activating NADPH oxidases which are a major enzymatic source of reactive oxygen species (ROS).
Anna Zimnol, Nora Spicker, Ronja Balhorn, Katrin Schröder, Nicole Schupp   +4 more
doaj   +1 more source

Knockout of the 15 kDa selenoprotein protects against chemically-induced aberrant crypt formation in mice. [PDF]

PLoS ONE, 2012
Evidence suggests that selenium has cancer preventive properties that are largely mediated through selenoproteins. Our previous observations demonstrated that targeted down-regulation of the 15 kDa selenoprotein (Sep15) in murine colon cancer cells ...
Petra A Tsuji, Bradley A Carlson, Salvador Naranjo-Suarez, Min-Hyuk Yoo, Xue-Ming Xu, Dmitri E Fomenko, Vadim N Gladyshev, Dolph L Hatfield, Cindy D Davis   +8 more
doaj   +1 more source

Immune Response in Stat2 Knockout Mice [PDF]

Immunity, 2000
Type I IFNs induce gene expression through Stat1 and Stat2, which can in turn associate either to form Stat1 homodimers or the transcription factor ISGF-3. Stat1 homodimers also transduce signals for IFN-gamma. To explore the unique properties of Stat2 and ISGF-3 in type I IFN signaling, its gene was targeted for deletion.
Christian Schindler, Edward Cha, Christopher Y. Park, Suzanne Li   +3 more
openaire   +3 more sources

Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice.

Gastroenterology, 2018
BACKGROUND & AIMS Defects in lysosome function and autophagy contribute to the pathogenesis of alcoholic liver disease. We investigated the mechanisms by which alcohol consumption affects these processes by evaluating the functions of transcription ...
Xiaojuan Chao, Shaogui Wang, Katrina Zhao, Yuan Li, Jessica A. Williams, Tiangang Li, Hemantkumar Chavan, Partha Krishnamurthy, Xi C. He, Linheng Li, A. Ballabio, Hong-Min Ni, W. Ding   +12 more
semanticscholar   +1 more source