Results 1 to 10 of about 121,927 (119)
Systemic autoimmunity in BAFF‐R‐mutant A/WySnJ strain mice [PDF]
European Journal of Immunology, 2008 AbstractSystemic lupus erythematosis is an autoimmune disease of unknown etiology. Lupus pathology is thought to reflect autoantibody‐mediated damage due to a failure of B lymphocyte tolerance. Since excessive B cell‐activating factor belonging to the TNF family (BAFF) expression correlates with human and murine lupus, and BAFF signals B cell survival ...
Colleen E. Hayes +3 more
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Histocompatible Colour Mutant from CBA/Lab Strain of Mice [PDF]
Nature, 1961 THE progeny from a breeding pair of CBA /Lab mice, a strain which is propagated by brother × sister mating, were found to have grey agouti coats in contrast to the usual wild-type agouti of the strain.
Brown, A M, Cook, M J
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Gastrointestinal Colonization by Candida albicans Mutant Strains in Antibiotic-Treated Mice [PDF]
Clinical Diagnostic Laboratory Immunology, 2001 ABSTRACT Antibiotic-treated mice orally inoculated with one of three Candida albicans strains (including two mutant strains) or indigenous Candida pelliculosa showed levels of candidal gastrointestinal colonization that were strain specific.
Robert P. Jechorek +4 more
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Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice [PDF]
Tuberculosis, 2010 Mycobacterium tuberculosis genome contains four related sets of an operon called mce (mce1-4). The disruption of one of these operons, mce1, causes M. tuberculosis to become hypervirulent, whereas the mce3 and mce4 operon mutants are attenuated in mice. This study examined the phenotype of the mce2 operon mutant.
Toshiko Miyata +4 more
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Impaired peripheral nerve regeneration in a mutant strain of mice (Enr) with a Schwann cell defect [PDF]
The Journal of Neuroscience, 1995 Schwann cell-axon interactions in the development, maintenance, and regeneration of the normal peripheral nervous system are complex. A previously described transgene-induced insertional mutation (BPFD#36), now referred to as Enervated (Enr), results in disrupted Schwann cell- axon interactions.
Brian Popko +3 more
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A new mutant at the Dystrophia muscularis (dy) locus in the SM strain of mice [PDF]
Laboratory Animals, 1985 Muscular dystrophy was found in the SM strain of mice. This defect was shown to be caused by a single autosomal recessive gene allelic with the genes at the dy locus. The dystrophic SM mice may provide a useful animal model for human muscular dystrophy, because SM strain has been selected for small body size and carries rare alleles at several loci.
S. Tsuji, Jun-ichiro Hayakawa
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Cryopreservation of Strains and Mutant Genes in Mice
Experimental Animals, 1987 Three kinds of freezing methods were tested with embryos of DNI strain. The survival rate after thawing was 47.5%, 66.7% and 77.8% in the 2-step method, modified slow freezing method and modified 2-step method, respectively. Then, the modified 2-step method was applied to the embryos from 7 strains and a pair of interstrain crosses.
Atsushi Yoshiki +2 more
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Strain-Dependent Anterior Segment Dysgenesis and Progression to Glaucoma inCol4a1Mutant Mice [PDF]
Investigative Opthalmology & Visual Science, 2015 Mutations in the gene encoding collagen type IV alpha 1 (COL4A1) cause multisystem disorders including anterior segment dysgenesis (ASD) and optic nerve hypoplasia. The penetrance and severity of individual phenotypes depends on genetic context. Here, we tested the effects of a Col4a1 mutation in two different genetic backgrounds to compare how genetic
Mao, Mao +7 more
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Microbiology, 1983 A proteinase-deficient mutant of Candida albicans, M12, was produced by nitrosoguanidine mutagenesis of a proteinase-producing strain, ATCC 28366. The mutant was phenotypically identical to its parent in nearly all biochemical and morphological characteristics except proteinase production.
Frank C. Odds, Fiona Macdonald
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Echo- and Electrocardiography in Mice: Establishment of Methods for Assessing Cardiac Function in Mutant Strains. • 132 [PDF]
Pediatric Research, 1997 Clinical evaluation of cardiac function in man involves echocardiography and electrocardiography to assess morphology and electrical activity. Development of genetically altered mice provides transgenic and knockout strains which may display abnormalities in myocardial function or cardiac signal transduction.
G. Michael Silberbach +5 more
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