Results 11 to 20 of about 256,488 (286)

Global regulator DksA modulates virulence of Acinetobacter baumannii

Virulence, 2021
DksA with (p)ppGpp regulates a wide range of gene transcriptions during the stringent response. The aim of this study was to identify a DksA ortholog in Acinetobacter baumannii and clarify the roles of DksA in bacterial physiology and virulence.
Nayeong Kim, Joo Hee Son, Kyeongmin Kim, Hyo Jeong Kim, Yoo Jeong Kim, Minsang Shin, Je Chul Lee   +6 more
doaj   +1 more source

Insulin 3-like hormone and its role in epididymo-testicular descent

International Brazilian Journal of Urology, 2007
PURPOSE: The role of insulin 3-like (Insl3) hormone signaling in the testicular descent process has been demonstrated. The purpose of the present study was to evaluate epididymal development in Insl3-deficient mice.
Faruk Hadziselimovic, Ibrahim Adham
doaj   +1 more source

DNA repair systems and the pathogenesis of Mycobacterium tuberculosis: varying activities at different stages of infection [PDF]

, 2010
Mycobacteria, including most of all MTB (Mycobacterium tuberculosis), cause pathogenic infections in humans and, during the infectious process, are exposed to a range of environmental insults, including the host's immune response.
Adams, Afanasev, Alina E. Gorna, Aly, Arnold, Bacon, Banu, Bergval, Betts, Boshoff, Boshoff, Bostanabad, Burney, Capelli, Chan, Chan, Cheng, Cooper, Cubillos-Ruiz, Darwin, Darwin, Das, Davis, Dos Vultos, Dubnau, Durbach, Farnia, Fennelly, Filliol, Fleischmann, Flint, Fontan, Friedberg, Frischkorn, Fu, Fu, Gaynor, Gordhan, Graham, Grishko, Guthlein, Hampshire, Hazbon, Hughes, Jain, Jaroslaw Dziadek, Jiao, Kapur, Karakousis, Karakousis, Karunkaran, Katti, Kesavan, Kim, Ko, Ko, Korycka-Machala, Krokan, Kurthkoti, Kurthkoti, Lari, Lever, Loudon, MacMicking, Malshetty, Martinez, Mokrousov, Moller, Movahedzadeh, Mulder, Munoz-Elias, Muttucumaru, Nguyen, Niemann, Nikolayevskyy, Nouvel, O'sullivan, Olano, Peccia, Peccia, Pitcher, Rachman, Rachman, Rad, Ramaswamy, Richard P. Bowater, Riley, Saito, Sander, Sassetti, Sassetti, Saunders, Schnappinger, Schwab, Sherman, Sinha, Sinha, Smeulders, Springer, Srivastava, Stephanou, Talaat, Talaat, Tang, Tsai, Venkatesh, Vilcheze, Voskuil, Voskuil, Waddell, Wanner, Warner, Weikert, Wiid, Wiseman, World Health Organization, Zaczek, Zainuddin   +117 more
core   +1 more source

Helicobacter pylori colonization ameliorates glucose homeostasis in mice through a PPAR γ-dependent mechanism. [PDF]

PLoS ONE, 2012
There is an inverse secular trend between the incidence of obesity and gastric colonization with Helicobacter pylori, a bacterium that can affect the secretion of gastric hormones that relate to energy homeostasis. H.
Josep Bassaganya-Riera, Maria Gloria Dominguez-Bello, Barbara Kronsteiner, Adria Carbo, Pinyi Lu, Monica Viladomiu, Mireia Pedragosa, Xiaoying Zhang, Bruno W Sobral, Shrinivasrao P Mane, Saroj K Mohapatra, William T Horne, Amir J Guri, Michael Groeschl, Gabriela Lopez-Velasco, Raquel Hontecillas   +15 more
doaj   +1 more source

Skin morphology of the mutant hairless USP mouse

Brazilian Journal of Medical and Biological Research, 2005
The morphology of the skin of the mutant hairless USP mouse was studied by histological, histochemical and immunohistochemical methods and compared to the skin of BALB/c mice.
S.M.G. Massironi, M.R. Giacóia, P.C. Maiorka, T.L. Kipnis, M.L.Z. Dagli   +4 more
doaj   +1 more source

The Mutation of the Genes Related to Neurovirulence in HSV-2 Produces an Attenuated Phenotype in Mice

Viruses, 2020
HSV-2 (Herpes simplex virus type 2) is a critical viral agent that mainly causes genital herpes and life-long latent infection in the dorsal root ganglia.
Lei Liu, Jishuai Cheng, Tangwei Mou, Ying Zhang, Xingli Xu, Jingjing Zhang, Xueqi Li, Xiao Feng, Xiangxiong Xu, Yun Liao, Shengtao Fan, Lichun Wang, Guorun Jiang, Qihan Li   +13 more
doaj   +1 more source

A live attenuated RHΔompdcΔuprt mutant of Toxoplasma gondii induces strong protective immunity against toxoplasmosis in mice and cats

Infectious Diseases of Poverty, 2023
Background Toxoplasma gondii is an obligate intracellular apicomplexan parasite and is responsible for zoonotic toxoplasmosis. It is essential to develop an effective anti-T.
Yu Shen, Bin Zheng, Hao Sun, Songrui Wu, Jiyuan Fan, Jianzu Ding, Meng Gao, Qingming Kong, Di Lou, Haojie Ding, Xunhui Zhuo, Shaohong Lu   +11 more
doaj   +1 more source

Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

eLife, 2021
Activating LRRK2 mutations cause Parkinson’s disease, and pathogenic LRRK2 kinase interferes with ciliogenesis. Previously, we showed that cholinergic interneurons of the dorsal striatum lose their cilia in R1441C LRRK2 mutant mice (Dhekne et al., 2018).
Shahzad S Khan, Yuriko Sobu, Herschel S Dhekne, Francesca Tonelli, Kerryn Berndsen, Dario R Alessi, Suzanne R Pfeffer   +6 more
doaj   +1 more source

Cryopreservation of Strains and Mutant Genes in Mice

Experimental Animals, 1987
Three kinds of freezing methods were tested with embryos of DNI strain. The survival rate after thawing was 47.5%, 66.7% and 77.8% in the 2-step method, modified slow freezing method and modified 2-step method, respectively. Then, the modified 2-step method was applied to the embryos from 7 strains and a pair of interstrain crosses.
A, Yoshiki, K, Ohno, N, Wakasugi
openaire   +3 more sources

Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice [PDF]

Tuberculosis, 2010
Mycobacterium tuberculosis genome contains four related sets of an operon called mce (mce1-4). The disruption of one of these operons, mce1, causes M. tuberculosis to become hypervirulent, whereas the mce3 and mce4 operon mutants are attenuated in mice. This study examined the phenotype of the mce2 operon mutant.
Olivera, Marjanovic, Toshiko, Miyata, Amador, Goodridge, Lon V, Kendall, Lee W, Riley   +4 more
openaire   +2 more sources