Results 31 to 40 of about 256,488 (286)

Virulence of Mycobacterium tuberculosis after Acquisition of Isoniazid Resistance: Individual Nature of katG Mutants and the Possible Role of AhpC. [PDF]

PLoS ONE, 2016
In the last decade, there were 10 million new tuberculosis cases per year globally. Around 9.5% of these cases were caused by isoniazid resistant (INHr) Mycobacterium tuberculosis (Mtb) strains.
Luisa Maria Nieto R, Carolina Mehaffy, Elizabeth Creissen, JoLynn Troudt, Amber Troy, Helle Bielefeldt-Ohmann, Marcos Burgos, Angelo Izzo, Karen M Dobos   +8 more
doaj   +1 more source

Francisella tularensis Schu S4 lipopolysaccharide core sugar and o-antigen mutants are attenuated in a mouse model of tularemia [PDF]

, 2014
The virulence factors mediating Francisella pathogenesis are being investigated, with an emphasis on understanding how the organism evades innate immunity mechanisms.
Apicella, Michael A, Gibson, Bradford W, Jones, Bradley D, Lindemann, Stephen R, Meyerholz, David K, Post, Deborah M.B., Rasmussen, Jed A   +6 more
core   +2 more sources

Attenuation of virulence in multiple serotypes (M1, M3, and M28) of Group A Streptococcus after the loss of secreted esterase

Journal of Microbiology, Immunology and Infection, 2022
Introduction: Group A Streptococcus (GAS) can produce streptococcal secreted esterase (Sse), which inhibits neutrophil recruitment to the site of infection and is crucial for GAS pathogenesis.
Xiaolan Zhang, Yuan Zhao, Yue Wang, Minghui Cai, Yingli Song, Hui Zhu   +5 more
doaj   +1 more source

In vitro and in vivo screening for novel essential cell-envelope proteins in Pseudomonas aeruginosa [PDF]

, 2015
The Gram-negative bacterium Pseudomonas aeruginosa represents a prototype of multi-drug resistant opportunistic pathogens for which novel therapeutic options are urgently required.
Bragonzi, Alessandra, Fernandez Pinar, Regina, Imperi, Francesco, LO SCIUTO, Alessandra, Ranucci, Serena, Rossi, Alice   +5 more
core   +1 more source

Differential immune responses of C57BL/6 mice to infection by Salmonella enterica serovar Typhimurium strain SL1344, CVCC541 and CMCC50115

Virulence, 2019
With a broad range of hosts, Salmonella enterica serovar Typhimurium (S. Typhimurium) is the major cause of gastroenteritis in human beings and systemic disease in susceptible mice strains. However, different S.
Shao Wei, Jianwei Huang, Zhexi Liu, Mengyao Wang, Bingkun Zhang, Zhengxing Lian, Yuming Guo, Hongbing Han   +7 more
doaj   +1 more source

Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection [PDF]

, 2017
Urinary tract infections: targeting enzymes might help Identifying bacterial and host enzymes that support biofilm formation may help prevent urinary tract infections caused by catheters.
Caparon, Michael G, Cusumano, Zachary T, Flores-Mireles, Ana L, Hultgren, Scott J, Takagi, Enzo, Xu, Wei   +5 more
core   +3 more sources

Strain-Dependent Anterior Segment Dysgenesis and Progression to Glaucoma inCol4a1Mutant Mice [PDF]

Investigative Opthalmology & Visual Science, 2015
Mutations in the gene encoding collagen type IV alpha 1 (COL4A1) cause multisystem disorders including anterior segment dysgenesis (ASD) and optic nerve hypoplasia. The penetrance and severity of individual phenotypes depends on genetic context. Here, we tested the effects of a Col4a1 mutation in two different genetic backgrounds to compare how genetic
Mao, Mao, Smith, Richard, Alavi, Marcel V, Marchant, Jeffrey K, Cosma, Mihai, Libby, Richard T, John, Simon W M, Gould, Douglas B   +7 more
openaire   +3 more sources

Differentiating inbred mouse strains from each other and those with single gene mutations using hair proteomics. [PDF]

PLoS ONE, 2012
Mutant laboratory mice with distinctive hair phenotypes are useful for identifying genes responsible for hair diseases. The work presented here demonstrates that shotgun proteomic profiling can distinguish hair shafts from different inbred mouse strains.
Robert H Rice, Katie M Bradshaw, Blythe P Durbin-Johnson, David M Rocke, Richard A Eigenheer, Brett S Phinney, John P Sundberg   +6 more
doaj   +1 more source

Salmonella Pathogenesis and Processing of Secreted Effectors by Caspase-3 [PDF]

, 2010
The enteric pathogen Salmonella enterica serovar Typhimurium causes food poisoning resulting in gastroenteritis. The S. Typhimurium effector Salmonella invasion protein A (SipA) promotes gastroenteritis by functional motifs that trigger either mechanisms
A. Maldonado-Contreras, B. A. McCormick, Barthel, C. V. Srikanth, Cherayil, Chiu, D. M. Wall, D. Zhou, Deane, H. N. Shi, Hueck, K. L. Mumy, Kim, Lee, Lee, Lee, Lilic, McCormick, McCormick, Nhan, Ohlson, Ramarao, Tran Van Nhieu, Wall, Wood, Z. Demma, Zakeri, Zhang, Zhou   +28 more
core   +1 more source

Gastrointestinal Colonization by Candida albicans Mutant Strains in Antibiotic-Treated Mice

Clinical Diagnostic Laboratory Immunology, 2001
ABSTRACT Antibiotic-treated mice orally inoculated with one of three Candida albicans strains (including two mutant strains) or indigenous Candida pelliculosa showed levels of candidal gastrointestinal colonization that were strain specific.
S M, Wiesner, R P, Jechorek, R M, Garni, C M, Bendel, C L, Wells   +4 more
openaire   +2 more sources