Results 41 to 50 of about 241,974 (292)
Frontiers in Physiology, 2020 Obesity has been described as a major factor of health risk in modern society. Next to intricately linked comorbidities like coronary artery disease or diabetes, an influence of obesity on regeneration after muscle injury has been described previously ...
Adrian Gihring +6 more
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Does a nephron deficit exacerbate the renal and cardiovascular effects of obesity? [PDF]
PLoS ONE, 2013 It has been hypothesized that a reduced nephron endowment exacerbates the hypertensive and renal effects of obesity. We therefore examined the impact of diet-induced obesity on renal structure and function, and arterial pressure in a genetic model of ...
Seshini Gurusinghe +6 more
doaj +1 more source
Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice. [PDF]
, 2014 The current dogma is that obesity-associated hepatic inflammation is due to increased Kupffer cell (KC) activation. However, recruited hepatic macrophages (RHMs) were recently shown to represent a sizable liver macrophage population in the context of ...
Bandyopadhyay, Gautam +14 more
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Hepatic Runx1t1 improves body fat index after endurance exercise in obese mice
Scientific Reports, 2023 Endurance exercise could attenuate obesity induced by high fat diet (HFD). Thus, the purpose of this study was to explore the crucial targets that play key roles in the improvement of body fat index (BFI) in obese mice by endurance exercise.
Ning Jiang +7 more
doaj +1 more source
Gut Microbes, 2022 Obesity causes chronic inflammation and changes in gut microbiome. However, how this contributes to poor survival and therapy resistance in patients with pancreatic cancer remain undetermined.
Kousik Kesh +10 more
doaj +1 more source
Spontaneous restoration of functional β‐cell mass in obese SM/J mice
Physiological Reports, 2020 Maintenance of functional β‐cell mass is critical to preventing diabetes, but the physiological mechanisms that cause β‐cell populations to thrive or fail in the context of obesity are unknown.
Mario A. Miranda +8 more
doaj +1 more source
Thrombospondin1 deficiency attenuates obesity-associated microvascular complications in ApoE-/- mice. [PDF]
PLoS ONE, 2015 Obesity is associated with insulin resistance and the increased development of vascular complications. Previously, we have demonstrated that thrombospondin1 (TSP1) regulates macrophage function and contributes to obesity associated inflammation and ...
Hasiyeti Maimaitiyiming +4 more
doaj +1 more source
High fat diet causes rebound weight gain [PDF]
, 2012 Acknowledgements This work was funded by a grant from Action Medical Research (SP4581).
McNay, David E. G., Speakman, John R.
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Effect of acute ozone exposure on the lung metabolomes of obese and lean mice. [PDF]
PLoS ONE, 2017 Pulmonary responses to the air pollutant, ozone, are increased in obesity. Both obesity and ozone cause changes in systemic metabolism. Consequently, we examined the impact of ozone on the lung metabolomes of obese and lean mice.
Joel Andrew Mathews +6 more
doaj +1 more source
Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress [PDF]
, 2018 Aim. Nonalcoholic steatohepatitis (NASH) is the consequence of insulin resistance, fatty acid accumulation, oxidative stress, and lipotoxicity.We hypothesize that an increase in the inflammatory adipokine NOV decreases antioxidant Heme Oxygenase 1 (HO- 1)
Abraham, Nader G. +13 more
core +1 more source