Results 71 to 80 of about 241,974 (292)

Extra-adrenal regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1:physiological regulator and pharmacological target for energy partitioning [PDF]

, 2007
The major glucocorticoid in man, cortisol, plays important roles in regulating fuel metabolism, energy partitioning and body fat distribution.
Alberts, Andrew, Brian R. Walker, Garrel, Havel, Lottenberg, Nowak, Pasquali, Paulmyer-Lacroix, Phillipou, Rask, Rosmond, Sapolsky, Stewart, Walker   +14 more
core   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity

Molecular Metabolism, 2016
Objective: A major challenge for obesity treatment is the maintenance of reduced body weight. Diet-induced obese mice are resistant to achieving normoweight once the obesogenic conditions are reversed, in part because lowered circulating leptin leads to ...
Kavaljit H. Chhabra, Jessica M. Adams, Graham L. Jones, Miho Yamashita, Martin Schlapschy, Arne Skerra, Marcelo Rubinstein, Malcolm J. Low   +7 more
doaj   +1 more source

The Physiology of Obese-Hyperglycemic Mice [ob/obMice] [PDF]

The Scientific World JOURNAL, 2007
This review summarizes key aspects of what has been learned about the physiology of leptin deficiency as it can be observed in obese-hyperglycemicob/obmice. These mice lack functional leptin. They are grossly overweight and hyperphagic, particularly at young ages, and develop severe insulin resistance.
openaire   +3 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Intravenous administration of bone marrow-derived multipotent mesenchymal stromal cells has a neutral effect on obesity-induced diabetic cardiomyopathy

Biological Research, 2013
Obesity is a major global health issue. Obese patients develop metabolic syndrome, which is a cluster of clinical features characterized by insulin resistance and dyslipidemia.
Sebastián D Calligaris, Paulette Conget
doaj   +1 more source

Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions [PDF]

, 2015
A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes.
Arble, Deanna M, Bass, Joseph, Behn, Cecilia Diniz, Butler, Matthew P, Challet, Etienne, Czeisler, Charles, Depner, Christopher M, Elmquist, Joel, Franken, Paul, Grandner, Michael A, Hanlon, Erin C, Joyner, Michael J, Karatsoreos, Ilia, Keene, Alex C, Kern, Philip A, Klein, Samuel, Morris, Christopher J, Pack, Allan I, Panda, Satchidananda, Ptacek, Louis J, Punjabi, Naresh M, Sassone-Corsi, Paolo, Saxena, Richa, Scheer, Frank A, Scheer, Frank A, Seaquest, Elizabeth R, Thimgan, Matthew S, Van Cauter, Eve, Wright, Kenneth P   +28 more
core   +4 more sources

The temporal trends and short‐ and long‐term mortality of people with acute myocardial infarction and rheumatoid arthritis: a nationwide cohort study

Arthritis Care &Research, Accepted Article.
Aims We investigated whether a diagnosis of rheumatoid arthritis (RA) affects the quality of inpatient acute myocardial infarction (AMI) care and long‐term mortality post‐AMI. Methods We analysed data from 784,091 adults, 6,047 with a diagnosis of RA, from England and Wales hospitalised with AMI between 2005 and 2019 from the MINAP registry, linked ...
Megan Butler, Nicholas Weight, Muhammad Rashid, Rodrigo Bagur, Purvi Parwani, Samantha Hider, Edward Roddy, Robert Butler, Mamas A Mamas   +8 more
wiley   +1 more source

Reduction of oxidative stress improves insulin signaling in cardiac tissue of obese mice

Einstein (São Paulo), 2020
Objective To evaluate the effects of oxidative stress on insulin signaling in cardiac tissue of obese mice. Methods Thirty Swiss mice were equally divided (n=10) into three groups: Control Group, Obese Group, and Obese Group Treated with N ...
Matheus Scarpatto Rodrigues, Bruno Luiz da Silva Pieri, Gustavo de Bem Silveira, Rubya Pereira Zaccaron, Ligia Milanez Venturini, Vitor Hugo Comin, Karine Damian Luiz, Paulo Cesar Lock Silveira   +7 more
doaj   +2 more sources

MCC950, a Selective NLRP3 Inhibitor, Attenuates Adverse Cardiac Remodeling Following Heart Failure Through Improving the Cardiometabolic Dysfunction in Obese Mice

Frontiers in Cardiovascular Medicine, 2022
Obesity is often accompanied by hypertension. Although a large number of studies have confirmed that NLRP3 inhibitors can improve cardiac remodeling in mice with a normal diet, it is still unclear whether NLRP3 inhibitors can improve heart failure (HF ...
Menglong Wang, Menglong Wang, Menglong Wang, Mengmeng Zhao, Mengmeng Zhao, Mengmeng Zhao, Junping Yu, Junping Yu, Junping Yu, Yao Xu, Yao Xu, Yao Xu, Jishou Zhang, Jishou Zhang, Jishou Zhang, Jianfang Liu, Jianfang Liu, Jianfang Liu, Zihui Zheng, Zihui Zheng, Zihui Zheng, Jing Ye, Jing Ye, Jing Ye, Zhen Wang, Zhen Wang, Zhen Wang, Di Ye, Di Ye, Di Ye, Yongqi Feng, Yongqi Feng, Yongqi Feng, Shuwan Xu, Shuwan Xu, Shuwan Xu, Wei Pan, Wei Pan, Wei Pan, Cheng Wei, Cheng Wei, Cheng Wei, Jun Wan, Jun Wan, Jun Wan   +44 more
doaj   +1 more source