Results 241 to 250 of about 2,313,243 (300)

Oxidative Stress in Huntington's Disease. [PDF]

Biomolecules
Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Cárcamo-Fonfría A, Caballero-Muñoz MDM, Agúndez JAG.   +5 more
europepmc   +1 more source

Organocatalytic Switches of DNA Glycosylase OGG1 Catalyze a Highly Efficient AP‐Lyase Function

Chemistry – A European Journal, EarlyView.
Organocatalytic switches are small molecules that combine active site affinity and a nitrogen‐centered base for catalysis, effectively removing the rate‐determining step of the OGG1 biochemical cascade. Here, we identify a minimal structure and modulate the active nitrogen pKa, enabling the catalysis of ultrafast AP site incisions in a range of pH ...
Mario Kehler, Kaixin Zhou, Aurino M. Kemas, Alicia del Prado, Emma Scaletti Hutchinson, Elinor Hesslefors Nairn, Marek Varga, Yvonne Plattner, Yi Zhong, Oryn Purewal‐Sidhu, James Haslam, Elisée Wiita, Heather Gildie, Karolina Singerova, Zuzanna Szaruga, Ingrid Almlöf, Femke M. Hormann, Kang‐Cheng Liu, Olov Wallner, Florian Ortis, Evert J. Homan, Opher Gileadi, Sean G. Rudd, Pål Stenmark, Miguel de Vega, Thomas Helleday, Nicholas D. D'Arcy‐Evans, Volker M. Lauschke, Maurice Michel   +28 more
wiley   +1 more source

Lithium and neuroprotection: a review of molecular targets and biological effects at subtherapeutic concentrations in preclinical models of Alzheimer's disease. [PDF]

Int J Bipolar Disord
De-Paula VJR, Radanovic M, Forlenza OV.
europepmc   +1 more source

Lewis‐X‐Containing Triterpenoid Saponins Inhibit DC‐SIGN‐ and L‐SIGN‐Mediated Transfer of HIV‐1 Infection

Chemistry – A European Journal, EarlyView.
The convergent synthesis of Lewis‐X‐containing betulinic acid and echinocystic acid saponins (1 and 2) is presented. The synthetic saponins were shown to inhibit, at the low micromolar range, the DC‐SIGN‐ and L‐SIGN‐mediated transfer of HIV‐1 infection to CD4‐positive cells, whereas free Lewis‐X, aglycones, and structurally similar triterpenoid ...
Oscar Javier Gamboa Marin, Kurtis Ng, Nitish Verma, Assi Gérard Flavien Yapi, Ralph Pantophlet, Charles Gauthier   +5 more
wiley   +1 more source

Modeling Alzheimer's Disease: A Review of Gene-Modified and Induced Animal Models, Complex Cell Culture Models, and Computational Modeling. [PDF]

Brain Sci
Timofeeva AM, Aulova KS, Nevinsky GA.
europepmc   +1 more source

Actin Isovariant ACT2‐Mediated Cellular Auxin Homeostasis Regulates Lateral Root Organogenesis in Arabidopsis thaliana

Cytoskeleton, EarlyView.
ABSTRACT Lateral root (LR) organogenesis is regulated by cellular flux of auxin within pericycle cells, which depends on the membrane distribution and polar localization of auxin carrier proteins. The correct distribution of auxin carrier proteins relies on the intracellular trafficking of these proteins aided by filamentous actin as a track.
Aya Hanzawa, Arifa Ahamed Rahman, Abidur Rahman   +2 more
wiley   +1 more source

Neural and vascular contributions to sensory impairments in a human alpha-synuclein transgenic mouse model of Parkinson's disease. [PDF]

J Cereb Blood Flow Metab
Lungu R, Fernandes FF, Pires Monteiro S, Outeiro TF, Shemesh N.   +4 more
europepmc   +1 more source

The PP2A‐B56 Binding Site LxxIxE Contributes to Asp‐Mediated Spindle Pole Stability

Cytoskeleton, EarlyView.
ABSTRACT The organization of microtubules into a mitotic spindle is critical for animal cell proliferation and involves the cooperation of hundreds of proteins whose molecular roles and regulation are not fully understood. The protein product of the Drosophila gene abnormal spindle, Asp, is a microtubule‐associated protein required for correct mitotic ...
Margaux Quiniou, Maria C. Burns, Aynsley McDermott, Karolina Jaworek, Stacey J. Scott, James G. Wakefield, Lori Borgal   +6 more
wiley   +1 more source

Correction of dysregulated lipid metabolism normalizes gene expression in oligodendrocytes and prolongs lifespan in female poly-GA C9orf72 mice. [PDF]

Nat Commun
Rezaei A, Kocsis-Jutka V, Gunes ZI, Zeng Q, Kislinger G, Bauernschmitt F, Isilgan HB, Parisi LR, Kaya T, Franzenburg S, Koppenbrink J, Knogler J, Arzberger T, Farny D, Nuscher B, Katona E, Dhingra A, Yang C, Gouna G, LaClair KD, Janjic A, Enard W, Zhou Q, Hagan N, Ofengeim D, Beltrán E, Gokce O, Simons M, Liebscher S, Edbauer D.   +29 more
europepmc   +1 more source

Amyloid Precursor Protein Haploinsufficiency Preferentially Mediates Brain Iron Accumulation in Mice Transgenic for The Huntington's Disease Mutation. [PDF]

J Huntingtons Dis, 2017
Berggren K, Agrawal S, Fox JA, Hildenbrand J, Nelson R, Bush AI, Fox JH.   +6 more
europepmc   +1 more source