Results 11 to 20 of about 350,087 (166)
BioTechniques, 2004 New high-throughput screening technologies have led to the identification of hundreds of genes with potential roles in cancer or other diseases. For evaluation of promising candidate genes, however, in-situ analysis of high numbers of clinical tissue samples is mandatory. The tissue microarray (TMA) technology greatly facilitates such analysis. In this
Simon R, Mirlacher M, Sauter G
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Developmental Science, 2006 Abstract Microarrays are revolutionizing genetics by making it possible to genotype hundreds of thousands of DNA markers and to assess the expression (RNA transcripts) of all of the genes in the genome. Microarrays are slides the size of a postage stamp that contain millions of DNA sequences to which single‐stranded DNA or RNA can hybridize.
Plomin, Robert, Schalkwyk, Leonard C
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Critical Care Medicine, 2005 Microarrays are simple assays that measure the relative expression levels of tens of thousands of genes. Excitement about their importance and potential contributions to biology and medicine has been intense. Nonetheless, recent insights into the limitations and pitfalls of microarrays have led to caution about data interpretation. Microarrays are very
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Sperm associated antigen 9 (SPAG9) a promising therapeutic target of ovarian carcinoma
Tumor Biology, 2018 SPAG9 is a novel tumor associated antigen, expressed in variety of malignancies. However, its role in ovarian cancer remains unexplored. SPAG9 expression was validated in ovarian cancer cells by real time PCR and Western blot.
Nirmala Jagadish +6 more
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Microarrays for microbiologists [PDF]
Microbiology, 2001 We are witnessing a remarkable change in the scale of molecular microbiological research and we are entering an era of ‘big science’. In the past decade we have moved from a time when entire research papers were based on the sequencing of a single gene or operon to a single paper describing the sequence of a whole genome.
S, Lucchini, A, Thompson, J C D, Hinton
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Plasma Cell-Free DNA Methylomics of Bipolar Disorder With and Without Rapid Cycling
Frontiers in Neuroscience, 2021 Rapid cycling (RC) burdens bipolar disorder (BD) patients further by causing more severe disability and increased suicidality. Because diagnosing RC can be challenging, RC patients are at risk of rapid decline due to delayed suitable treatment.
Ada Man-Choi Ho +9 more
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Frontiers in Oncology, 2021 PurposeThis study aimed to explore the circular RNA (circRNA/circ) profile engaged in non-small cell lung cancer (NSCLC) development and metastasis and to investigate potentially key carcinogenic circRNAs related to NSCLC.MethodsCircRNA profiles between ...
Qiushi Wang +8 more
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Autoimmunity, 2020 Inhalation of crystalline silica (cSiO2) in the workplace is etiologically linked to lupus and other autoimmune diseases. Exposing lupus-prone NZBWF1 mice to respirable cSiO2 unleashes a vicious cycle of inflammation and cell death in the lung that ...
Lichchavi D. Rajasinghe +9 more
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Cells, 2022 Besides being a powerful model to study the mechanisms of corneal wound healing, tissue-engineered human corneas (hTECs) are sparking interest as suitable substitutes for grafting purposes. To ensure the histological and physiological integrity of hTECs,
Gaëtan Le-Bel +6 more
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Cancer Informatics, 2013 Background Breast tumors have been described by molecular subtypes characterized by pervasively different gene expression profiles. The subtypes are associated with different clinical parameters and origin of precursor cells.
Mads Thomassen +3 more
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