Results 11 to 20 of about 349,535 (265)
BioTechniques, 2004 New high-throughput screening technologies have led to the identification of hundreds of genes with potential roles in cancer or other diseases. For evaluation of promising candidate genes, however, in-situ analysis of high numbers of clinical tissue samples is mandatory. The tissue microarray (TMA) technology greatly facilitates such analysis. In this
Simon R, Mirlacher M, Sauter G
openaire +10 more sources
Developmental Science, 2006 Abstract Microarrays are revolutionizing genetics by making it possible to genotype hundreds of thousands of DNA markers and to assess the expression (RNA transcripts) of all of the genes in the genome. Microarrays are slides the size of a postage stamp that contain millions of DNA sequences to which single‐stranded DNA or RNA can hybridize.
Plomin, Robert, Schalkwyk, Leonard C
openaire +4 more sources
Critical Care Medicine, 2005 Microarrays are simple assays that measure the relative expression levels of tens of thousands of genes. Excitement about their importance and potential contributions to biology and medicine has been intense. Nonetheless, recent insights into the limitations and pitfalls of microarrays have led to caution about data interpretation. Microarrays are very
openaire +4 more sources
Microarrays for microbiologists [PDF]
Microbiology, 2001 We are witnessing a remarkable change in the scale of molecular microbiological research and we are entering an era of ‘big science’. In the past decade we have moved from a time when entire research papers were based on the sequencing of a single gene or operon to a single paper describing the sequence of a whole genome.
S, Lucchini, A, Thompson, J C D, Hinton
openaire +2 more sources
Transcription factor GATA6 promotes migration of human coronary artery smooth muscle cells in vitro
Frontiers in Physiology, 2022 Vascular smooth muscle cell plasticity plays a pivotal role in the pathophysiology of vascular diseases. Despite compelling evidence demonstrating the importance of transcription factor GATA6 in vascular smooth muscle, the functional role of GATA6 ...
Azra Alajbegovic +6 more
doaj +1 more source
Autoimmunity, 2020 Inhalation of crystalline silica (cSiO2) in the workplace is etiologically linked to lupus and other autoimmune diseases. Exposing lupus-prone NZBWF1 mice to respirable cSiO2 unleashes a vicious cycle of inflammation and cell death in the lung that ...
Lichchavi D. Rajasinghe +9 more
doaj +1 more source
Plasma Cell-Free DNA Methylomics of Bipolar Disorder With and Without Rapid Cycling
Frontiers in Neuroscience, 2021 Rapid cycling (RC) burdens bipolar disorder (BD) patients further by causing more severe disability and increased suicidality. Because diagnosing RC can be challenging, RC patients are at risk of rapid decline due to delayed suitable treatment.
Ada Man-Choi Ho +9 more
doaj +1 more source
Cancer Informatics, 2013 Background Breast tumors have been described by molecular subtypes characterized by pervasively different gene expression profiles. The subtypes are associated with different clinical parameters and origin of precursor cells.
Mads Thomassen +3 more
doaj +1 more source
Replication Study: Transcriptional amplification in tumor cells with elevated c-Myc
eLife, 2018 As part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Blum et al., 2015), that described how we intended to replicate selected experiments from the paper ‘Transcriptional amplification in tumor cells with elevated c ...
L Michelle Lewis +6 more
doaj +1 more source
Frontiers in Oncology, 2021 PurposeThis study aimed to explore the circular RNA (circRNA/circ) profile engaged in non-small cell lung cancer (NSCLC) development and metastasis and to investigate potentially key carcinogenic circRNAs related to NSCLC.MethodsCircRNA profiles between ...
Qiushi Wang +8 more
doaj +1 more source