Results 31 to 40 of about 344,370 (242)

Combining bioinformatics and machine learning to identify common mechanisms and biomarkers of chronic obstructive pulmonary disease and atrial fibrillation

open access: yesFrontiers in Cardiovascular Medicine, 2023
BackgroundPatients with chronic obstructive pulmonary disease (COPD) often present with atrial fibrillation (AF), but the common pathophysiological mechanisms between the two are unclear.
Ziyi Sun   +11 more
doaj   +1 more source

Cytology Microarrays

open access: yesAnalytical Cellular Pathology, 2007
The use of high throughput genetic and expression platforms are generating many candidate diagnostic markers and therapeutic targets for a wide variety of clinical conditions. Tissue microarrays can be used for the evaluation of the utility of many of these markers.
J. Korbelik   +4 more
openaire   +3 more sources

Ensifer meliloti L6-AK89, an Effective Inoculant of Medicago lupulina Varieties: Phenotypic and Deep-Genome Screening

open access: yesAgronomy, 2022
This paper presents a deep analysis of the accessory genome of an economically promising strain of Ensifer (Sinorhizobium) meliloti, L6-AK89, obtained as a result of next-generation high-throughput sequencing (MiSeq, MinIon).
Marina L. Roumiantseva   +7 more
doaj   +1 more source

Small EVs-Associated DNA as Complementary Biomarker to Circulating Tumor DNA in Plasma of Metastatic Colorectal Cancer Patients

open access: yesPharmaceuticals, 2021
It is widely accepted that assessing circular tumor DNA (ctDNA) in the plasma of cancer patients is a promising practice to evaluate somatic mutations from solid tumors noninvasively.
Silvia Galbiati   +10 more
doaj   +1 more source

Protein Microarrays [PDF]

open access: yes, 2009
Protein microarrays containing nearly the entire yeast proteome have been constructed. They are typically prepared by overexpression and high-throughput purification and printing onto microscope slides. The arrays can be used to screen nearly the entire proteome in an unbiased fashion and have enormous utility for a variety of applications.
Fasolo, Joseph, Snyder, Michael
openaire   +2 more sources

Gut Microbiota as an Epigenetic Regulator: Pilot Study Based on Whole-Genome Methylation Analysis

open access: yesmBio, 2014
The core human gut microbiota contributes to the developmental origin of diseases by modifying metabolic pathways. To evaluate the predominant microbiota as an epigenetic modifier, we classified 8 pregnant women into two groups based on their dominant ...
Himanshu Kumar   +6 more
doaj   +1 more source

A Facile and Scalable Hydrogel Patterning Method for Microfluidic 3D Cell Culture and Spheroid-in-Gel Culture Array

open access: yesBiosensors, 2021
Incorporation of extracellular matrix (ECM) and hydrogel in microfluidic 3D cell culture platforms is important to create a physiological microenvironment for cell morphogenesis and to establish 3D co-culture models by hydrogel compartmentalization. Here,
Chengxun Su   +5 more
doaj   +1 more source

Lectin microarray [PDF]

open access: yesPROTEOMICS – Clinical Applications, 2009
AbstractLectin microarray is a new technology that utilizes a panel of lectins immobilized on well‐defined substrate for high‐throughout analysis of glycans and glycoproteins. In this article, we have reviewed the fabrication and detection schemes in lectin microarray and discussed its novel applications in glycomics. We have also demonstrated a lectin
Shen, Hu, David T, Wong
openaire   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Single nucleotide recognition using a probes-on-carrier DNA chip

open access: yesBioTechniques, 2019
Following the sequencing of the human genome, SNP analysis of individual patients has become essential for achieving the best drug response and ensuring optimal care.
Satoshi Fuke   +2 more
doaj   +1 more source

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