Results 31 to 40 of about 907,938 (379)

Microarray-based ultra-high resolution discovery of genomic deletion mutations [PDF]

open access: yes, 2014
BACKGROUND: Oligonucleotide microarray-based comparative genomic hybridization (CGH) offers an attractive possible route for the rapid and cost-effective genome-wide discovery of deletion mutations.
Baban, D.   +8 more
core   +3 more sources

Blood‐derived DNA methylation predictors of mortality discriminate tumor and healthy tissue in multiple organs

open access: yesMolecular Oncology, 2020
Evidence has shown that certain methylation markers derived from blood can mirror corresponding methylation signatures in internal tissues. In the current study, we aimed to investigate two strong epigenetic predictors for life span, derived from blood ...
Yan Zhang   +6 more
doaj   +1 more source

Coupled Two-Way Clustering Analysis of Gene Microarray Data [PDF]

open access: yes, 2000
We present a novel coupled two-way clustering approach to gene microarray data analysis. The main idea is to identify subsets of the genes and samples, such that when one of these is used to cluster the other, stable and significant partitions emerge ...
Alizadeh   +12 more
core   +4 more sources

Differential gene expression graphs: A data structure for classification in DNA microarrays [PDF]

open access: yes, 2008
This paper proposes an innovative data structure to be used as a backbone in designing microarray phenotype sample classifiers. The data structure is based on graphs and it is built from a differential analysis of the expression levels of healthy and ...
Benso, Alfredo   +3 more
core   +1 more source

Registered report: Transcriptional amplification in tumor cells with elevated c-Myc

open access: yeseLife, 2015
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of 50 papers in the field of cancer biology published between 2010 and 2012.
David Blum   +3 more
doaj   +1 more source

Analysing Microarray Data using the Multi-functional Immune Ontologiser

open access: yesJournal of Integrative Bioinformatics, 2006
Gene expression microarrays are a prominent experimental tool in functional genomics allowing researchers to gain a deeper understanding of biological processes.
Khalid Sabah   +4 more
doaj   +1 more source

Crosstalk between Receptor and Non-receptor Mediated Chemical Modes of Action in Rat Livers Converges through a Dysregulated Gene Expression Network at Tumor Suppressor Tp53

open access: yesFrontiers in Genetics, 2017
Chemicals, toxicants, and environmental stressors mediate their biologic effect through specific modes of action (MOAs). These encompass key molecular events that lead to changes in the expression of genes within regulatory pathways.
Karen M. Funderburk   +3 more
doaj   +1 more source

Profound effect of profiling platform and normalization strategy on detection of differentially expressed microRNAs [PDF]

open access: yes, 2012
Adequate normalization minimizes the effects of systematic technical variations and is a prerequisite for getting meaningful biological changes. However, there is inconsistency about miRNA normalization performances and recommendations.
Kaiser, Sebastian   +4 more
core   +1 more source

Cleaning the Medicago Microarray Database to Improve Gene Function Analysis

open access: yesPlants, 2021
Transcriptomics studies have been facilitated by the development of microarray and RNA-Seq technologies, with thousands of expression datasets available for many species.
Francesca Marzorati   +4 more
doaj   +1 more source

A preliminary transcriptomic approach to elucidate post harvest ripening of plum fruit [PDF]

open access: yes, 2010
The aim of the present study was to dissect common and/or diverse mechanisms regulating plum (Prunus salicina) fruit ripening in genotypes characterized by different patterns of ethylene production. Fruit of an ethylenesuppressed cultivar ('Shiro') and a
Bonghi, Claudio   +2 more
core   +2 more sources

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