Results 21 to 30 of about 50 (49)
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The Design of New Drugs That Resist Microbial Inactivation
Clinical Infectious Diseases, 1979Several possible strategems for overcoming the development of bacterial resistance are discussed. The design of new drugs that resist microbial inactivation is reviewed, with particular emphasis on the aminoglycoside and beta-lactam antibiotics. Examples of alteration of the inactivation site, decreased enzyme affinity, steric hindrance of enzymic ...
L. D. Cama +2 more
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1989
Most often when the subject of antimicrobial resistance is discussed, the organizational emphasis is on individual antimicrobial agents or groups of agents. Thus we tend to see discussion of resistance to f3-lactams, tetracyclines, amino glycosides etc.
L. E. Bryan, A. Böck
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Most often when the subject of antimicrobial resistance is discussed, the organizational emphasis is on individual antimicrobial agents or groups of agents. Thus we tend to see discussion of resistance to f3-lactams, tetracyclines, amino glycosides etc.
L. E. Bryan, A. Böck
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Exploring Microbial Nanotoxicity Against Drug Resistance in Bacteria
2021The growing threat of antimicrobial resistance on human health urgently calls for the need to look for novel solutions to mitigate the grave effect of this global problem and save thousands of lives each year. Nanotechnology is an emerging area that is expected to be able to have solutions toward containing the rise and spread of multidrug-resistant ...
Rajeshwari Sinha +2 more
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Microbial Development of Drug Resistance: Mechanisms and Clinical Significance
CRC Critical Reviews in Clinical Laboratory Sciences, 1975Bacteria have demonstrated a disconcerting ability to develop resistance to antimicrobial agents nearly as quickly as new compounds become available. During the past two decades the molecular bases of several types of resistance have been elucidated.
Ruth M. Lawrence +2 more
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Repositioning of non-antibiotic drugs as an alternative to microbial resistance: a systematic review
International Journal of Antimicrobial Agents, 2021The global spread of microbial resistance coupled with high costs and slow pace in the discovery of a new antibiotic have made drug repositioning an attractive and promising alternative in the treatment of infections caused by multidrug resistant (MDR) microorganisms. The reuse involves the production of compounds with lower costs and development time,
Vitória S. Foletto +4 more
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Microbial Pathogenesis and Antimicrobial Drug Resistance
2020Antimicrobial drug resistance has become a serious threat and it caused the death of 700,000 individuals in 2016. Gram-negative bacteria such as Acinetobacter, Pseudomonas, Enterobacter spp. Enterococcus faecium, Staphylococcus aureus, and Klebsiella pneumoniae are insensitive to antibiotics. E. faecium, S. aureus, K.
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Anti‐Microbial Drug Resistance: A Human Disaster in the Making
World Medical & Health Policy, 2011AbstractAnti‐microbial drug resistance (AMR or AMDR) is a complex multi‐dimensional and systemic failure in health education, social behavior, health care legislation and/or policies and practices. AMDR is a life threatening infection extending beyond national boundaries.
Thomas Zimmerman +3 more
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Herbs and Drug Resistance: Part 1—Herbs and Microbial Resistance to Antibiotics
Alternative and Complementary Therapies, 2002M icrobial resistance to drugs has grown remarkably, and with each passing decade, new resistance emerges. The sulfonamide antibiotics were initially effective against group A streptococci and pneumococci but, within 10 years, developed modes of resistance.
Kathy Abascal, Eric Yarnell
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Proteomics Approaches to Uncover the Drug Resistance Mechanisms of Microbial Biofilms [PDF]
, 2017 The current chapter describes the potential of proteomics in understanding the drug resistance mechanisms of microbial biofilms. One of the most important and intriguing properties of microbial biofilms is their increased resistance to challenging environmental conditions.
Juan Antonio Vizcaíno +3 more
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Weapons of Microbial Drug Resistance Abound in Soil Flora
Science, 2006Bacteria found in soils show robust resistance to many antibiotics. These protective mechanisms may offer clues for generating a new arsenal of therapeutic drugs.
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