Results 31 to 40 of about 3,295,358 (263)

Integrating pan-genome with metagenome for microbial community profiling

Computational and Structural Biotechnology Journal, 2021
Advances in sequencing technology have led to the increased availability of genomes and metagenomes, which has greatly facilitated microbial pan-genome and metagenome analysis in the community.
Chaofang Zhong, Chaoyun Chen, Lusheng Wang, Kang Ning   +3 more
doaj   +1 more source

Supervised Machine Learning Enables Geospatial Microbial Provenance

, 2022
The recent increase in publicly available metagenomic datasets with geospatial metadata has made it possible to determine location-specific, microbial fingerprints from around the world.
Bagchi, Debneel, Bhattacharya, Bodhisatwa, Somsubhro Mukherjee, Henaff, Elizabeth M., Hastings, Jaden J. A., Jaden J. A. Hastings, Hastings, Jaden J.A., Srijani Basu, Krista A. Ryon, Malay Bhattacharyya, Christopher E. Mason, Basu, Srijani, Braden T. Tierney, Lu Wang, Bodhisatwa Bhattacharya, Ryon, Krista A., Tierney, Braden T., Elizabeth M. Henaff, Bhattacharya, Chandrima, Mason, Christopher E., Mukherjee, Somsubhro, Debneel Bagchi, Wang, Lu, Chandrima Bhattacharya, Bhattacharyya, Malay   +24 more
core   +1 more source

Microbial genomics amidst the Arctic crisis [PDF]

, 2020
The Arctic is warming – fast. Microbes in the Arctic play pivotal roles in feedbacks that magnify the impacts of Arctic change. Understanding the genome evolution, diversity and dynamics of Arctic microbes can provide insights relevant for both ...
Edwards, Arwyn, Rassner, Sara M.E., Cook, Joseph M., Cameron, Karen, Furness, Eleanor, Hay, Melanie C., Debbonaire, Aliyah R.   +6 more
core   +1 more source

The hidden genetic reservoir: structural variants as drivers of marine microbial and viral microdiversity

Environmental Microbiome
Background Intraspecific genetic diversity is fundamental to understanding microbial adaptation, evolution, and contributions to ecosystem stability.
Jose M. Haro-Moreno, Juan J. Roda-Garcia, Carmen Molina-Pardines, Mario López-Pérez   +3 more
doaj   +1 more source

Intra-Host Evolution of SARS-CoV-2 During Persistent Infection of Pediatric COVID-19 Patients

Viruses
The Coronavirus disease 2019 (COVID-19) pandemic had a profound global impact, yet children exhibited distinct clinical and epidemiological patterns compared to adults.
Charlie R. Boyle, Tien Doan, Estefany Rios-Guzman, Jessica Maciuch, Lacy M. Simons, Dulce S. Garcia, David B. Williams, Arghavan Alisoltani, Egon A. Ozer, Ramon Lorenzo-Redondo, Judd F. Hultquist   +10 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Comparative genomics on gene and single nucleotide level [PDF]

, 2013
Blom J. Comparative genomics on gene and single nucleotide level.
Blom, Jochen
core  

I-PREFR: Inverse PCR-Based Restriction Enzyme FRee Unidirectional Strategy for Rapid Markerless Chromosomal Gene Deletion and Reconstitution in Bacteria Using Suicide Vectors

Bio-Protocol
The standard protocols for allelic exchange using homologous recombination deploy suicide vectors with negative selection markers. However, the use of multiple restriction enzymes to generate sticky ends in the vector and the insert for cloning is time ...
Rekha Rana, Anushika Sharma, Ashish Dutta, Prabhu Patil   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source