Results 61 to 70 of about 39,725 (303)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Comparative Genomics of Lactobacillus crispatus from the Gut and Vagina Reveals Genetic Diversity and Lifestyle Adaptation

, 2020
Lactobacillus crispatus colonizes the human feces, human vagina, and the crops and ceca of chicken. To explore the genetic characteristics and evolutionary relationships of L. crispatus isolated from different niches, we selected 37 strains isolated from
Paul Ross, Qiuxiang Zhang, Hao Zhang, Wei Chen, Lili Zhang, Jianxin Zhao   +5 more
core   +1 more source

Corrigendum: Five decades of genome evolution in the globally distributed, extensively antibiotic-resistant acinetobacter baumannii global clone 1 (Microbial Genomics 2016, 2, 10.1099/mgen.0.000052) [PDF]

, 2019
© 2019, Microbiology Society. All rights reserved. There was a change in the author names in the published article. The new list should read: Kathryn E. Holt1, Johanna J. Kenyon2, Mohammad Hamidian3, Mark B. Schultz4, Derek J.
Holt, KE, Hamidian, M, Pickard, DJ, Hall, RM, Kenyon, JJ, Schultz, MB, Dougan, G   +6 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Co Evolution of Man and Microbial Pathogenic Genome

Molecular Biology, 2015
Background: Co-evolution of human and microbial genome is of fundamental interest. It allows both the human and pathogens to adapt themselves in the changing environment. Even in an experimental condition to check resistance against a particular antibiotic the microbes slowly develop resistance against that antibiotic in laboratory environment. Thus it
Ambreen Ayub, Yasra Sarwar, Waseem Akhtar shamshari   +2 more
openaire   +1 more source

Comparative genomics defines the core genome of the growing N4-like phage genus and identifies N4-like Roseophage specific genes [PDF]

, 2014
Two bacteriophages, RPP1 and RLP1, infecting members of the marine Roseobacter clade were isolated from seawater. Their linear genomes are 74.7 and 74.6 kb and encode 91 and 92 coding DNA sequences, respectively.
Schäfer, Hendrik, Jacqueline Zoe-Munn Chan, Nicholas Harold Mann, Chan, Jacqueline, Andrew David Millard, Millard, Andrew D., Jacqueline Z.-M. Chan, Mann, Nicholas H., Hendrik eSchäfer, Andrew D. Millard, Nicholas H. Mann, Hendrik Schäfer   +11 more
core   +1 more source

Lose-lose consequences of bacterial community-driven invasions in soil

Microbiome
Background Community-driven invasion, also known as community coalescence, occurs widely in natural ecosystems. Despite that, our knowledge about the process and mechanisms controlling community-driven invasion in soil ecosystems is lacking.
Xipeng Liu, Joana Falcão Salles
doaj   +1 more source

Polycistronic transcription of fused cassettes and identification of translation initiation signals in an unusual gene cassette array from Pseudomonas aeruginosa [version 3; referees: 2 approved]

F1000Research, 2015
The gene cassettes found in class 1 integrons are generally promoterless units composed by an open reading frame (ORF), a short 5’ untranslated region (UTR) and a 3’ recombination site (attC).
Érica L. Fonseca, Ana Carolina Paulo Vicente   +1 more
doaj   +1 more source

Genome Evolution in Bacteria Isolated from Million-Year-Old Subseafloor Sediment

mBio, 2021
Beneath the seafloor, microbial life subsists in isolation from the surface world under persistent energy limitation. The nature and extent of genomic evolution in subseafloor microbes have been unknown.
William D. Orsi, Tobias Magritsch, Sergio Vargas, Ömer K. Coskun, Aurele Vuillemin, Sebastian Höhna, Gert Wörheide, Steven D’Hondt, B. Jesse Shapiro, Paul Carini   +9 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source