Results 11 to 20 of about 588,081 (304)

Microbial Medicine Industry: Current Status and Future Trends

中国工程科学, 2021
The microbial sourced natural products possess diverse structures and excellent activities, implying great potentials for clinical application. This study systematically analyzes the current status of the microbial medicine industry in China and ...
Yu Qing, Huang Tingting, Deng Zixin
doaj   +1 more source

The Streptomyces viridochromogenes product template domain represents an evolutionary intermediate between dehydratase and aldol cyclase of type I polyketide synthases

Communications Biology, 2022
Structural analyses of a Streptomyces viridochromogenes product template (PT) domain suggests molecular and functional similarities with known fungal PTs involved in polyketide synthase activity.
Yuanyuan Feng, Xu Yang, Huining Ji, Zixin Deng, Shuangjun Lin, Jianting Zheng   +5 more
doaj   +1 more source

New genomic insights into “Entotheonella” symbionts in Theonella swinhoei: mixotrophy, anaerobic adaptation, resilience, and interaction

Frontiers in Microbiology, 2016
Entotheonella (phylum Tectomicrobia) is a filamentous symbiont that produces almost all known bioactive compounds derived from the Lithistida sponge Theonella swinhoei.
Fang Liu, Jinlong Li, Guofang Feng, Zhiyong Li   +3 more
doaj   +1 more source

A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells. [PDF]

, 2019
Microbial metabolites are an emerging class of mediators influencing CD4+ T-cell function. To advance the understanding of direct causal microbial factors contributing to Crohn's disease, we screened 139 predicted Crohn's disease-associated microbial ...
Borneman, James, Braun, Jonathan, Bushman, Frederic, Casero, David, Chang, Yu-Ling, Harre, Nicholas, Humphries, Romney, Huttenhower, Curtis, Lewis, James, McGovern, Dermot PB, Miller, Shelley, Rossetti, Maura, Salzman, Nita, Sartor, R Balfour, Simpson, Kenneth W, Stappenbeck, Thaddeus, Sunga, Gemalene, Vlamakis, Hera, Wu, Gary, Xavier, Ramnik   +19 more
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Influence of coral and algal exudates on microbially mediated reef metabolism. [PDF]

, 2013
Benthic primary producers in tropical reef ecosystems can alter biogeochemical cycling and microbial processes in the surrounding seawater. In order to quantify these influences, we measured rates of photosynthesis, respiration, and dissolved organic ...
Carlson, Craig A., Haas, Andreas F., Hatay, Mark, Leichter, James J., Leichter, Jeffrey, Nelson, Craig E., Quistad, Steven D., Rohwer, Forest, Smith, Jennifer E., Wegley-Kelly, Linda   +9 more
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A severe leakage of intermediates to shunt products in acarbose biosynthesis

Nature Communications, 2020
Biosynthetic mechanism for the type 2 diabetes treatment drug acarbose is not fully revealed. Here, the authors show that shunt pathways and inefficient amino-deoxyhexose biosynthesis lead to 1-epi-valienol and valienol accumulation, and minimizing the ...
Qinqin Zhao, Yuchang Luo, Xin Zhang, Qianjin Kang, Dan Zhang, Lili Zhang, Linquan Bai, Zixin Deng   +7 more
doaj   +1 more source

The effect of calorie intake, fasting, and dietary composition on metabolic health and gut microbiota in mice

BMC Biology, 2021
Background Calorie restriction (CR) and intermittent fasting (IF) can promote metabolic health through a process that is partially mediated by gut microbiota modulation.
Ziyi Zhang, Xiaoyu Chen, Yuh Jiun Loh, Xin Yang, Chenhong Zhang   +4 more
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Mesophilic Argonaute-based isothermal detection of SARS-CoV-2

Frontiers in Microbiology, 2022
Coronavirus disease (COVID-19), caused by SARS-CoV-2 infection and its mutations, has spread rapidly all over the world and still requires sensitive detection to distinguish mutations.
Xiao Li, Huarong Dong, Xiang Guo, Fei Huang, Xiaoyi Xu, Nuolan Li, Yu Yang, Tianbao Yao, Yan Feng, Qian Liu   +9 more
doaj   +1 more source

Impact of the gut microbiota on inflammation, obesity, and metabolic disease [PDF]

, 2016
The human gut harbors more than 100 trillion microbial cells, which have an essential role in human metabolic regulation via their symbiotic interactions with the host.
Boulangé, CL, Chilloux, J, Dumas, ME, Neves, AL, Nicholson, JK   +4 more
core   +1 more source

Comparative genome-centric analysis reveals seasonal variation in the function of coral reef microbiomes [PDF]

, 2020
Microbially mediated processes contribute to coral reef resilience yet, despite extensive characterisation of microbial community variation following environmental perturbation, the effect on microbiome function is poorly understood.
Bourne, David G., Glasl, Bettina, Laffy, Patrick W., Marangon, Emma, Robbins, Steven, Rodrigues Frade, Pedro, Webster, Nicole S.   +6 more
core   +2 more sources