Results 81 to 90 of about 675,129 (379)

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

The volatile microbiome [PDF]

Genome Biology, 2011
The first detailed temporal study of the human microbiome shows that individual body habitats exhibit surprising variation over time yet maintain distinguishable community structures.
openaire   +2 more sources

Engineering natural microbiomes toward enhanced bioremediation by microbiome modeling

Nature Communications
Engineering natural microbiomes for biotechnological applications remains challenging, as metabolic interactions within microbiomes are largely unknown, and practical principles and tools for microbiome engineering are still lacking.
Zhepu Ruan, Kai Chen, Weimiao Cao, Lei Meng, Bingang Yang, Mengjun Xu, Youwen Xing, Pengfa Li, Shiri Freilich, Chen Chen, Yanzheng Gao, Jiandong Jiang, Xihui Xu   +12 more
semanticscholar   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

A synbiotic mixture of selected oligosaccharides and bifidobacteria assists murine gut microbiota restoration following antibiotic challenge

Microbiome, 2023
Background Typically, animal models studying gastrointestinal microbiotas compromised in early life have employed either germ-free animals or mice treated with a cocktail of antibiotics. Such studies intend to mimic scenarios of infants born by caesarean
Emily C. Hoedt, Cara M. Hueston, Nora Cash, Roger S. Bongers, Jonathan M. Keane, Kees van Limpt, Kaouther Ben Amor, Jan Knol, John MacSharry, Douwe van Sinderen   +9 more
doaj   +1 more source

Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

Gut microbes, 2022
The human intestine hosts diverse microbial communities that play a significant role in maintaining gut-skin homeostasis. When the relationship between gut microbiome and the immune system is impaired, subsequent effects can be triggered on the skin ...
Md. Rayhan Mahmud, Sharmin Akter, Sanjida Khanam Tamanna, Lincon Mazumder, Israt Zahan Esti, Sanchita Banerjee, Sumona Akter, Md Rakibul Hasan, Mrityunjoy Acharjee, Md Sajjad Hossain, A. Pirttilä   +10 more
semanticscholar   +1 more source

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma

Nature Medicine, 2022
The composition of the gut microbiome has been associated with clinical responses to immune checkpoint inhibitor (ICI) treatment, but there is limited consensus on the specific microbiome characteristics linked to the clinical benefits of ICIs.
KarlaA Lee, A. M. Thomas, L. Bolte, J. Björk, L. K. de Ruijter, F. Armanini, F. Asnicar, A. Blanco-Míguez, R. Board, N. Calbet-Llopart, L. Derosa, N. Dhomen, K. Brooks, M. Harland, M. Harries, E. Leeming, P. Lorigan, P. Manghi, R. Marais, J. Newton-Bishop, L. Nezi, Federica Pinto, M. Potrony, S. Puig, P. Serra-Bellver, H. Shaw, S. Tamburini, S. Valpione, Amrita Vijay, L. Waldron, L. Zitvogel, Moreno Zolfo, E. de Vries, Paul Nathan, R. Fehrmann, V. Bataille, G. Hospers, T. Spector, R. Weersma, N. Segata   +39 more
semanticscholar   +1 more source

Gut microbiota in HIV-pneumonia patients is related to peripheral CD4 counts, lung microbiota, and in vitro macrophage dysfunction. [PDF]

, 2019
Pneumonia is common and frequently fatal in HIV-infected patients, due to rampant, systemic inflammation and failure to control microbial infection. While airway microbiota composition is related to local inflammatory response, gut microbiota has been ...
Byanyima, Patrick, Chang, Emily, Davis, J Lucian, Fadrosh, Douglas W, Fong, Serena, Huang, Laurence, Kaswabuli, Sylvia, Lin, Din L, Lynch, Susan V, McCauley, Kathryn, Musisi, Emmanuel, Sanyu, Ingvar, Shenoy, Meera K, Worodria, William, Zawedde, Josephine   +14 more
core   +2 more sources

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source