Results 81 to 90 of about 913,863 (385)

Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer

Nature, 2022
The tumour-associated microbiota is an intrinsic component of the tumour microenvironment across human cancer types 1 , 2 . Intratumoral host–microbiota studies have so far largely relied on bulk tissue analysis 1 – 3 , which obscures the spatial ...
J. L. Galeano Niño, Hanrui Wu, Kaitlyn D. Lacourse, Andrew G. Kempchinsky, Alexander A. Baryiames, Brittany Barber, N. Futran, J. Houlton, C. Sather, E. Sicinska, A. Taylor, S. Minot, C. D. Johnston, S. Bullman   +13 more
semanticscholar   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Gut microbiota influence immunotherapy responses: mechanisms and therapeutic strategies

Journal of Hematology & Oncology, 2022
The gut microbiota have long been recognized to play a key role in human health and disease. Currently, several lines of evidence from preclinical to clinical research have gradually established that the gut microbiota can modulate antitumor immunity and
Yuting Lu, Xiangliang Yuan, Miao Wang, Z. He, Hongzhong Li, Ji Wang, Qin Li   +6 more
semanticscholar   +1 more source

Lower Airway Microbiota [PDF]

Frontiers in Pediatrics, 2019
During the last several years, the interest in the role of microbiota in human health has grown significantly. For many years, the lung was considered a sterile environment, and only recently, with the use of more sophisticated techniques, has it been demonstrated that colonization by a complex population of microorganisms in lower airways also occurs ...
Salvatore Savasta, Amelia Licari, Giuseppe Fabio Parisi, Alessandro Giallongo, Sara Manti, Sara Manti, Gian Luigi Marseglia, Giulio Pulvirenti, Maria Papale, Salvatore Leonardi   +9 more
openaire   +8 more sources

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

The Role of Intestinal Fungi in the Pathogenesis and Treatment of Ulcerative Colitis

Microorganisms
Ulcerative colitis (UC) is a chronic inflammatory bowel disease closely associated with dysbiosis of the gut microbiome, encompassing not only bacterial communities but also fungal populations. Despite the growing recognition of the gut microbiome’s role
Yujing Zhang, Lin Wang, Lihua Peng
doaj   +1 more source

Longitudinal Evaluation of Gut Bacteriomes and Viromes after Fecal Microbiota Transplantation for Eradication of Carbapenem-Resistant Enterobacteriaceae

mSystems, 2022
Understanding the role of fecal microbiota transplantation (FMT) in the decolonization of multidrug-resistant organisms (MDRO) is critical. Specifically, little is known about virome changes in MDRO-infected subjects treated with FMT.
Qin Liu, Tao Zuo, Wenqi Lu, Yun Kit Yeoh, Qi Su, Zhilu Xu, Whitney Tang, Keli Yang, Fen Zhang, Louis H. S. Lau, Rashid N. S. Lui, Miu Ling Chin, Rity Wong, Chun Pan Cheung, Wenyi Zhu, Paul K. S. Chan, Francis K. L. Chan, Grace C. Lui, Siew C. Ng   +18 more
doaj   +1 more source

Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism

Gut microbes, 2016
The formation of SCFA is the result of a complex interplay between diet and the gut microbiota within the gut lumen environment. The discovery of receptors, across a range of cell and tissue types for which short chain fatty acids SCFA appear to be the ...
D. Morrison, T. Preston
semanticscholar   +1 more source

A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia

Molecular Psychiatry, 2022
The emerging understanding of gut microbiota as ‘metabolic machinery’ influencing many aspects of physiology has gained substantial attention in the field of psychiatry. This is largely due to the many overlapping pathophysiological mechanisms associated
A. McGuinness, J. Davis, S. Dawson, A. Loughman, F. Collier, M. O’hely, C. Simpson, J. Green, W. Marx, C. Hair, G. Guest, M. Mohebbi, M. Berk, D. Stupart, D. Watters, F. Jacka   +15 more
semanticscholar   +1 more source

Research progress on the metabolic transformation of Shenling Baizhu San under the influence of the gut microbiota

Advanced Chinese Medicine, EarlyView.
Abstract The gut microbiota plays a pivotal role in maintaining host metabolic homeostasis and overall physiological functions. Shenling Baizhu San (SLBZS), a time‐honored classical prescription for tonifying Qi, strengthening the spleen, removing dampness, and arresting diarrhea, has shown broad clinical efficacy in digestive disorders.
Jinlan Di, Xiaochun Zhang
wiley   +1 more source