Results 81 to 90 of about 844,915 (312)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Ammonia exposure induced intestinal inflammation injury mediated by intestinal microbiota in broiler chickens via TLR4/TNF-α signaling pathway

Ecotoxicology and Environmental Safety, 2021
Ammonia is a known environmental pollutant that causes injury to the intestine. Growing evidence suggests that intestinal microbiota dysbiosis involves in the development of intestinal injury under environmental pollution. However, the specific mechanism
Ying Zhou, Minhong Zhang, Xin Zhao, Jinghai Feng   +3 more
doaj   +1 more source

Impact of Intestinal Microbiota on Intestinal Luminal Metabolome [PDF]

Scientific Reports, 2012
Low-molecular-weight metabolites produced by intestinal microbiota play a direct role in health and disease. In this study, we analyzed the colonic luminal metabolome using capillary electrophoresis mass spectrometry with time-of-flight (CE-TOFMS) -a novel technique for analyzing and differentially displaying metabolic profiles- in order to clarify the
Matsumoto, Mitsuharu, Kibe, Ryoko, Ooga, Takushi, Aiba, Yuji, Kurihara, Shin, Sawaki, Emiko, Koga, Yasuhiro, Benno, Yoshimi   +7 more
openaire   +2 more sources

Preterm gut microbiota and metabolome following discharge from intensive care [PDF]

, 2015
The development of the preterm gut microbiome is important for immediate and longer-term health following birth. We aimed to determine if modifications to the preterm gut on the neonatal intensive care unit (NICU) impacted the gut microbiota and ...
Skeath, Tom, Perry, J. D. (John), Nelson, Andrew, Stewart, Christopher, Marrs, Emma, Embleton, Nicholas, Fernstad, Sara J., Fernstad, Sara Johansson, Berrington, Janet, Marrs, E. C. L. (Emma), Cummings, Stephen, Perry, John, Skeath, Thomas   +12 more
core   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Roles of the intestinal microbiota and microbial metabolites in acute GVHD

Experimental Hematology & Oncology, 2021
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the most curative strategies for the treatment of many hematologic malignancies and diseases. However, acute graft-versus-host disease (GVHD) limits the success of allo-HSCT.
Dandan Lin, Bo Hu, Pengfei Li, Ye Zhao, Yang Xu, Depei Wu   +5 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Intestinal microbiota and arthritis

EULAR Rheumatology Open
Intestinal dysbiosis appears as a common denominator among several rheumatic diseases. Here, we provide an overview of the most commonly occurring themes in the relationship between intestinal microbiota, host response, and arthritic disease.
Emilie Dumas, Dirk Elewaut
openaire   +3 more sources

Lymphoma Caused by Intestinal Microbiota [PDF]

International Journal of Environmental Research and Public Health, 2014
The intestinal microbiota and gut immune system must constantly communicate to maintain a balance between tolerance and activation: on the one hand, our immune system should protect us from pathogenic microbes and on the other hand, most of the millions of microbes in and on our body are innocuous symbionts and some can even be beneficial.
Yamamoto, Mitsuko L, Schiestl, Robert H
openaire   +4 more sources

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source