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An empirical model of carbon-ion relative biological effectiveness based on the linear correlation between radiosensitivity to photons and carbon ions. [PDF]
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Radiation and Environmental Biophysics, 2022
To predict the biological effects of ionising radiation, the quantity of biological dose is introduced instead of the physical absorbed dose. In proton therapy, a constant relative biological effectiveness (RBE) of 1.1 is usually applied clinically as recommended by the International Commission of Radiation Units and Measurements. This study presents a
Hossein Taghipour, Payvand Taherparvar
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To predict the biological effects of ionising radiation, the quantity of biological dose is introduced instead of the physical absorbed dose. In proton therapy, a constant relative biological effectiveness (RBE) of 1.1 is usually applied clinically as recommended by the International Commission of Radiation Units and Measurements. This study presents a
Hossein Taghipour, Payvand Taherparvar
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Adaptation of the microdosimetric kinetic model to hypoxia
Physics in Medicine and Biology, 2016Ion beams present a potential advantage in terms of treatment of lesions with hypoxic regions. In order to use this potential, it is important to accurately model the cell survival of oxic as well as hypoxic cells. In this work, an adaptation of the microdosimetric kinetic (MK) model making it possible to account for cell hypoxia is presented.
C, Bopp +5 more
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Microdosimetric-Kinetic Model for Radio-enhancement of Gold Nanoparticles: Comparison with LEM
Radiation Research, 2020Numerous studies have strongly supported the application of gold nanoparticles (GNPs) as radio-enhanced agents. In our previous study, the local effect model (LEM I) was adopted to predict the cell survival for MDA-MB-231 cells exposed to 150 kVp X rays after 500 µg/ml GNPs treatment.
Hyejin, Kim, Wonmo, Sung, Sung-Joon, Ye
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A modified microdosimetric kinetic model for relative biological effectiveness calculation
Physics in Medicine & Biology, 2017In the heavy ion therapy, not only the distribution of physical absorbed dose, but also the relative biological effectiveness (RBE) weighted dose needs to be taken into account. The microdosimetric kinetic model (MKM) can predict the RBE value of heavy ions with saturation-corrected dose-mean specific energy, which has been used in clinical treatment ...
Yizheng, Chen +4 more
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Relative biological effectiveness study of Lipiodol based on microdosimetric-kinetic model
Physica Medica, 2018We examine the contrast agent Lipiodol effect on the relative biological effectiveness (RBE) values for flattening filter free (FFF) and flattening filter (FF) beams of 6 MV-Xray (6 MVX) and 10 MVX.Lipiodol was placed at 5 cm depth in water. According to the microdosimetric kinetic model, the RBE values for killing the human liver hepatocellular cells ...
Daisuke Kawahara +10 more
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Formation of spread-out Bragg peak for helium-ion beam using microdosimetric kinetic model
Physica Medica, 2023To evaluate the applicability of microdosimetric kinetic model (MKM) to helium-ion therapy by forming a spread-out Bragg peak (SOBP) of a helium-ion beam using the MKM developed for carbon-ion radiotherapy and confirming the predictions in biological experiments.Using a ridge filter, a 90-mm wide SOBP for a 210 MeV/u helium-ion beam was created in a ...
Takashi Akagi +3 more
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International Journal of Radiation Biology, 2021
The stochastic microdosimetric kinetic (SMK) model is one of the most sophisticated and precise models used in the estimation of the relative biological effectiveness of carbon-ion radiotherapy (CRT) and boron neutron capture therapy (BNCT). However, because of its complicated and time-consuming calculation procedures, it is nearly impractical to ...
Tatsuhiko, Sato +4 more
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The stochastic microdosimetric kinetic (SMK) model is one of the most sophisticated and precise models used in the estimation of the relative biological effectiveness of carbon-ion radiotherapy (CRT) and boron neutron capture therapy (BNCT). However, because of its complicated and time-consuming calculation procedures, it is nearly impractical to ...
Tatsuhiko, Sato +4 more
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Physics in Medicine & Biology, 2018
The microdosimetric kinetic (MK) model underestimates the cell-survival fractions for high linear energy transfer (LET) and high dose irradiations. To address the issue, some researchers previously extended the MK model to the stochastic microdosimetric kinetic (SMK) model.
T Inaniwa, N Kanematsu
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The microdosimetric kinetic (MK) model underestimates the cell-survival fractions for high linear energy transfer (LET) and high dose irradiations. To address the issue, some researchers previously extended the MK model to the stochastic microdosimetric kinetic (SMK) model.
T Inaniwa, N Kanematsu
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Physics in Medicine & Biology, 2020
To develop a Monte Carlo (MC)-based and robust ion beam therapy optimization system that separates the optimization algorithm from the relative biological effectiveness (RBE) modeling. Robustly optimized dose distributions were calculated and compared across three ion therapy beams (proton, helium, carbon).
Jiasen, Ma +5 more
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To develop a Monte Carlo (MC)-based and robust ion beam therapy optimization system that separates the optimization algorithm from the relative biological effectiveness (RBE) modeling. Robustly optimized dose distributions were calculated and compared across three ion therapy beams (proton, helium, carbon).
Jiasen, Ma +5 more
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