Results 81 to 90 of about 15,118,660 (165)

Mixed- and multi-relative biological effectiveness model simultaneous optimization in carbon ion radiotherapy: A proof-of-concept

Physics and Imaging in Radiation Oncology
Background and purpose: In carbon ion radiotherapy (CIRT), different relative biological effectiveness (RBE) models have been used for calculating RBE-weighted dose (DRBE).
Aaron Paul Osburg, Peter Lysakovski, Giuseppe Magro, Semi Harrabi, Thomas Haberer, Amir Abdollahi, Jürgen Debus, Thomas Tessonnier, Andrea Mairani   +8 more
doaj   +1 more source

Generalized stochastic microdosimetric model: The main formulation

, 2021
The present work introduces a rigorous stochastic model, called the generalized stochastic microdosimetric model (GSM^{2}), to describe biological damage induced by ionizing radiation.
M. Missiaggia, S. M. Welford, C. La Tessa, Missiaggia, M, Attili, A, Scifoni, E, F. Cordoni, Cordoni, F, La Tessa, C, A. Attili, Welford, S M, E. Scifoni   +11 more
core   +1 more source

Erratum to "A systematic analysis of the particle irradiation data ensemble in the key of the microdosimetric kinetic model: Should clonogenic data be used for clinical relative biological effectiveness?" [Radiother. Oncol. 185 (2023) 109730]. [PDF]

Radiother Oncol, 2023
Suárez-García D, Cortés-Giraldo MA, Bertolet A.   +2 more
europepmc   +1 more source

Stochastic Microdosimetric Kinetic model for hypo-fractionated multi-ion therapy

, 2019
The microdosimetric kinetic (MK) model is a biological model used to predict cell-survival fractions from the specific energy absorbed by a microscopic subnuclear structure, domain, for various radiations.
Mizushima, Kota, Hara, Yousuke, 784476, 784477, 784478, 784479, 784469, Inaniwa, Taku, 784480, 784470, 784481, 784471, 784482, Kanematsu, Nobuyuki, 784472, Tansho, Ryohei, 784473, 784474, 784475, Suzuki, Masao, Sung-Hyun, Lee   +20 more
core  

A deep learning model for predicting the modified micro-dosimetric kinetic model-based dose and the dose-averaged linear energy transfer for prostate cancer in carbon ion therapy

Physics and Imaging in Radiation Oncology
Adaptive carbon ion radiotherapy for localized prostate cancer requires accurate evaluation of biological dose and dose-averaged linear energy transfer (LETd) changes.
Liwen Zhang, Weiwei Wang, Ping Li, Qing Zhang, Rongcheng Han   +4 more
doaj   +1 more source

Establishment of a practical methodology for evaluating equieffective dose of individual patients based on RT-PHITS

EJNMMI Physics
Background The RadioTherapy package based on PHITS (RT-PHITS) is an individual dosimetry system applicable to both targeted radionuclide therapy (TRT) and external radiotherapy.
Tatsuhiko Sato, Takuya Furuta, Hidetaka Sasaki, Tadashi Watabe   +3 more
doaj   +1 more source

Relative Biological Effectiveness (RBE) of Monoenergetic Protons: Comparison of Empirical and Biophysical Models

Applied Sciences
A constant proton relative biological effectiveness (RBE) of 1.1 for tumor control is currently used in proton therapy treatment planning. However, in vitro, in vivo and clinical experiences indicate that proton RBE varies with kinetic energy and ...
Dimitris Dalalas, Alexis Papadopoulos, Ioanna Kyriakou, Robert D. Stewart, Pantelis Karaiskos, Dimitris Emfietzoglou   +5 more
doaj   +1 more source

Optimizing the modified microdosimetric kinetic model input parameters for proton and $^4$He ion beam therapy application

, 2017
Models able to predict relative biological effectiveness (RBE) values are necessary for an accurate determination of the biological effect with proton and $^4$He ion beams.
T Haberer, Mairani, A, Molinelli, S, K Parodi, Böhlen, T T, A Mairani, Ferrari, A, Magro, G, Tessonnier, T, S Molinelli, Parodi, K, Debus, J, T T Böhlen, A Ferrari, Haberer, T, G Magro, T Tessonnier, J Debus   +17 more
core   +1 more source

Cell Survival Computation via the Generalized Stochastic Microdosimetric Model (GSM2); Part II: Numerical Results

In the present paper we numerically investigate, using Monte Carlo simulation, the theoretical results predicted by the Generalized Stochastic Microdosimetric Model (GSM2), as shown in the published companion paper.
Scifoni, E., Tessa, C. La, La Tessa, Chiara, Missiaggia, M., Cordoni, F. G.   +4 more
core   +1 more source

Cell-Survival Fraction Estimation Based on the Probability Densities of Domain and Cell Nucleus Specific Energies Using Improved Microdosimetric Kinetic Models

Estimation of the survival fractions of cells irradiated with various particles over a wide linear energy transfer (LET) range is of great importance in the treatment planning of charged-particle therapy.
462186, Sato, Tatsuhiko, Furusawa, Yoshiya, 古澤 佳也, 462187, 462188   +5 more
core