Results 71 to 80 of about 1,371 (176)

Relevance of accurate Monte Carlo modeling in nuclear medical imaging [PDF]

, 1999
Monte Carlo techniques have become popular in different areas of medical physics with advantage of powerful computing systems. In particular, they have been extensively applied to simulate processes involving random behavior and to quantify physical ...
Zaidi, H
core   +1 more source

Commissioning of a commercial treatment planning system for scanned carbon‐ion radiotherapy

Journal of Applied Clinical Medical Physics, Volume 26, Issue 3, March 2025.
Abstract Purpose To commission the RayStation (RS) TPS (treatment planning system) for scanned CIRT (carbon‐ion radiotherapy) utilizing pencil beam algorithms (PBv4.2). Methods The beam model commissioning entailed employing 1D single beams and 2D monoenergetic fields to validate spot profiles with films, assess beam range using Peakfinder measurements,
Wei Sun, Weiwei Wang, Zhijie Huang, Jingfang Zhao   +3 more
wiley   +1 more source

Finnish Dosimetric Practice for Epithermal Neutron Beam Dosimetry in Boron Neutron Capture Therapy [PDF]

, 2009
Boron neutron capture therapy (BNCT) is a form of chemically targeted radiotherapy that utilises the high neutron capture cross-section of boron-10 isotope to achieve a preferential dose increase in the tumour.
Uusi-Simola, Jouni
core  

Beyond a constant proton relative biological effectiveness: A survey of clinical and research perspectives among proton institutions in Europe and the United States

Journal of Applied Clinical Medical Physics, Volume 26, Issue 1, January 2025.
Abstract Purpose Although proton relative biological effectiveness (RBE) depends on factors like linear energy transfer (LET), tissue properties, dose, and biological endpoint, a constant RBE of 1.1 is recommended in clinical practice. This study surveys proton institutions to explore activities using functionalities beyond a constant proton RBE ...
Jakob Ödén, Kjell Eriksson, Suryakant Kaushik, Erik Traneus   +3 more
wiley   +1 more source

Novel radiation quality metrics accounting for proton energy spectra for RBE proton models

Medical Physics, Volume 51, Issue 8, Page 5773-5782, August 2024.
Abstract Background For proton therapy, a relative biological effectiveness (RBE) of 1.1 is widely applied clinically. However, due to abundant evidence of variable RBE in vitro, and as suggested in studies of patient outcomes, RBE might increase by the end of the proton tracks, as described by several proposed variable RBE models.
Fredrik Kalholm, Iuliana Toma‐Dasu, Erik Traneus, Niels Bassler   +3 more
wiley   +1 more source

The sensitivity of radiobiological models in carbon ion radiotherapy (CIRT) and its consequences on the clinical treatment plan: Differences between LEM and MKM models

Journal of Applied Clinical Medical Physics, Volume 25, Issue 7, July 2024.
Abstract Purpose Carbon ion radiotherapy (CIRT) relies on relative biological effectiveness (RBE)‐weighted dose calculations. Japanese clinics predominantly use the microdosimetric kinetic model (MKM), while European centers utilize the local effect model (LEM). Despite both models estimating RBE‐distributions in tissue, their physical and mathematical
Joanna Góra, Sarah Grosshagauer, Piero Fossati, Marta Mumot, Markus Stock, Mansure Schafasand, Antonio Carlino   +6 more
wiley   +1 more source

Evaluation of the availability of single‐position treatment with a rotating gantry and the validity of deformable image registration dose assessment for pancreatic cancer carbon‐ion radiotherapy

Journal of Applied Clinical Medical Physics, Volume 25, Issue 6, June 2024.
Abstract Background This study aimed to evaluate the clinical acceptability of rotational gantry‐based single‐position carbon‐ion radiotherapy (CIRT) to reduce the gastrointestinal (GI) dose in pancreatic cancer. We also evaluated the usefulness of the deformable image registration (DIR)‐based dosimetry method for CIRT.
Yuya Miyasaka, Shohei Kawashiro, Sung Hyun Lee, Hikaru Souda, Mayumi Ichikawa, Hongbo Chai, Miyu Ishizawa, Takuya Ono, Hiraku Sato, Takeo Iwai   +9 more
wiley   +1 more source

Microdosimetric Evaluation of Physical and Biological Quantities due to Linear Energy Transfer in Proton Therapy Using Monte Carlo Simulation [PDF]

Iranian South Medical Journal
Background: In proton therapy, it is imperative to take the distribution of both the physical absorbed dose and the biological dose into account. Therefore, phenomenological models and a biophysical model such as microdosimetric kinetic model (MKM) have ...
Hossien Taghipour, Seyed Mohammad Motevalli, Paivand Taherparvar   +2 more
doaj  

Dose averaged linear energy transfer optimization for large sacral chordomas in carbon ion therapy

Medical Physics, Volume 51, Issue 6, Page 3950-3960, June 2024.
Abstract Background Carbon ion beams are well accepted as densely ionizing radiation with a high linear energy transfer (LET). However, the current clinical practice does not fully exploit the highest possible dose‐averaged LET (LETd) and, consequently, the biological potential in the target.
Mansure Schafasand, Andreas Franz Resch, Ankita Nachankar, Joanna Góra, Giovanna Martino, Erik Traneus, Lars Glimelius, Dietmar Georg, Piero Fossati, Antonio Carlino, Markus Stock   +10 more
wiley   +1 more source

Renormalization of radiobiological response functions by energy loss fluctuations and complexities in chromosome aberration induction: deactivation theory for proton therapy from cells to tumor control

, 2019
We employ a multi-scale mechanistic approach to investigate radiation induced cell toxicities and deactivation mechanisms as a function of linear energy transfer in hadron therapy.
Abolfath, Ramin, Bronk, Lawrence, Carabe, Alejandro, Grosshans, David, Helo, Yusuf, Mohan, Radhe   +5 more
core   +1 more source