Results 61 to 70 of about 15,118,660 (165)

A model for relative biological effectiveness of therapeutic proton beams based on a global fit of cell survival data

Scientific Reports, 2017
We introduce an approach for global fitting of the recently published high-throughput and high accuracy clonogenic cell-survival data for therapeutic scanned proton beams.
Ramin Abolfath, Christopher R. Peeler, Mark Newpower, Lawrence Bronk, David Grosshans, Radhe Mohan   +5 more
doaj   +1 more source

Dynamic control of carbon‐ion radiation dose distribution amid respiratory motion challenges: A review of prediction research using geant4 and deep learning physics‐constrained models

Journal of Applied Clinical Medical Physics, Volume 27, Issue 11, November 2026.
Abstract Background Carbon ion radiotherapy (CIRT) offers superior dose conformity and biological effectiveness; however, its precision is highly sensitive to respiratory motion, leading to dose uncertainty and interplay effects that compromise treatment accuracy.
Jianhua Ding, Peng Li, Chai Hong Yeong
wiley   +1 more source

Model assembly for estimating cell surviving fraction for both targeted and nontargeted effects based on microdosimetric probability densities.

PLoS ONE, 2014
We here propose a new model assembly for estimating the surviving fraction of cells irradiated with various types of ionizing radiation, considering both targeted and nontargeted effects in the same framework.
Tatsuhiko Sato, Nobuyuki Hamada
doaj   +1 more source

Impact of robust optimization and beam configuration on the distribution stability of LET under delivery uncertainties in carbon‐ion therapy

Journal of Applied Clinical Medical Physics, Volume 27, Issue 11, November 2026.
Abstract Background Carbon‐ion radiotherapy exploits high linear energy transfer (LET) to enhance biological effectiveness, and low dose‐averaged LET (LETd) within the target volume is associated with local recurrence in pancreatic cancer. Although robust optimization is widely used to improve dose robustness against delivery uncertainties, systematic ...
Wisawa Phongprapun, Mutsumi Tashiro
wiley   +1 more source

Microdosimetric study for helium-ion beam using fully 3D silicon microdosimeters

, 2020
In this study, the survival fraction of pancreatic cancer cells exposed to a spread-out Bragg peak (SOBP) helium-ion beam are estimated using the microdosimetric method with the microdosimetric kinetic (MK) model, by measuring the specific energy with a ...
M Suzuki (7698428), T Inaniwa (20226516), R Kohno (20870273), SH Lee (7941245), K Mizushima (20870270), Dousatsu Sakata (19587241), T Shirai (20870279), Anatoly Rozenfeld (19587706), VA Pan (20870282), Y Iwata (19887354), M Sakama (20870276), LT Tran (11242554)   +11 more
core   +1 more source

Establishment of a new three-dimensional dose evaluation method considering variable relative biological effectiveness and dose fractionation in proton therapy combined with high-dose-rate brachytherapy

Journal of Medical Physics, 2019
Purpose: The purpose of this study is to evaluate the influence of variable relative biological effectiveness (RBE) of proton beam and dose fractionation has on dose distribution and to establish a new three-dimensional dose evaluation method for proton ...
Daisuke Kobayashi, Tomonori Isobe, Kenta Takada, Yutaro Mori, Hideyuki Takei, Hiroaki Kumada, Satoshi Kamizawa, Tetsuya Tomita, Eisuke Sato, Hiroshi Yokota, Takeji Sakae   +10 more
doaj   +1 more source

An ion treatment planning framework for inclusion of nanodosimetric ionization detail through cluster dose

Medical Physics, Volume 53, Issue 8, August 2026.
Abstract Background Nanodosimetry relates the cumulative or statistical moments of Ionization Detail (ID) with biological endpoints of relevance to cancer radiotherapy using charged particles. This association suggests to develop an additional physics‐detailed layer of modeling that may complement biological modeling and treatment planning.
Simona Facchiano, Ramon Ortiz, Remo Cristoforetti, Naoki D‐Kondo, Oliver Jäkel, Bruce Faddegon, Niklas Wahl   +6 more
wiley   +1 more source

Feasibility of upright carbon ion radiotherapy for prostate cancer: Dosimetric comparison between supine and upright postures

Medical Physics, Volume 53, Issue 7, July 2026.
Abstract Background Carbon ion radiotherapy (CIRT) in the upright posture is a treatment technique which delivers carbon ion beams from a fixed direction to patients who sit or stand on a rotating chair. Although various potential advantages of the upright positioning have been discussed, feasibility of upright CIRT for prostate cancer has not been ...
Yusuke Nomura, Taku Inaniwa, Yoshitake Yamada, Minoru Yamada, Yoichi Yokoyama, Hideyuki Mizuno, Shunsuke Yonai, Yoshiyuki Iwata, Kohei Oguma, Junichi Fukada, Naoyuki Shigematsu, Atsuya Takeda, Hitoshi Ishikawa, Masahiro Jinzaki   +13 more
wiley   +1 more source

Stochastic microdosimetric kinetic model for hypo-fractionated multi-ion therapy

, 2020
To date, more than 10,000 patients of various tumour sites have been treated with therapeutic carbon-ion beams at the National Institute of Radiological Sciences (NIRS).
858540, 858541, Sakata, Dousatsu, 858539, 858536, Suzuki, Masao, 858537, 858538, 858542, Inaniwa, Taku, 858543, Sung-Hyun, Lee   +11 more
core  

Parameterising microdosimetric distributions of mono-energetic proton beams for fast estimates of yD and y∗

, 2020
Wepresent analytical models of the dose-mean lineal energy (yD) and the saturation-corrected dosemean lineal energy (y∗) for fast and accurate radiobiological calculations in proton therapy.
Baratto-Roldan, Anna, Carabe, Alejandro, Perales, A., Cortés-Giraldo, Miguel Antonio, Kimstrand, P.   +4 more
core   +1 more source