Results 41 to 50 of about 1,371 (176)

Microdosimetric Modeling of Biological Effectiveness for Boron Neutron Capture Therapy Considering Intra- and Intercellular Heterogeneity in 10B Distribution [PDF]

, 2018
We here propose a new model for estimating the biological effectiveness for boron neutron capture therapy (BNCT) considering intra- and intercellular heterogeneity in 10B distribution.
Hamada Nobuyuki, Kumada Hiroaki, Masunaga Shin-ichiro, Sato Tatsuhiko, 熊田 博明   +4 more
core   +3 more sources

Advancement of microdosimetric kinetic model in heavy-ion radiotherapy

Journal of Physics: Conference Series, 2020
Abstract To date, more than 11,000 cancer patients have been treated with therapeutic carbon-ion beams at the National Institute of Radiological Sciences (NIRS). In the treatment planning system, the biological effectiveness of the therapeutic carbon-ion beams has been predicted based on the microdosimetric kinetic (MK) model.
openaire   +1 more source

Brainstem NTCP and Dose Constraints for Carbon Ion RT—Application and Translation From Japanese to European RBE-Weighted Dose

Frontiers in Oncology, 2020
Background and PurposeThe Italian National Center of Oncological Hadrontherapy (CNAO) has applied dose constraints for carbon ion RT (CIRT) as defined by Japan’s National Institute of Radiological Sciences (NIRS).
Jon Espen Dale, Jon Espen Dale, Silvia Molinelli, Barbara Vischioni, Viviana Vitolo, Maria Bonora, Giuseppe Magro, Andrea Mairani, Andrea Mairani, Azusa Hasegawa, Azusa Hasegawa, Tatsuya Ohno, Olav Dahl, Francesca Valvo, Piero Fossati, Piero Fossati   +15 more
doaj   +1 more source

Modelling the HPRT-gene mutation induction of particle beams: systematic in vitro data collection, analysis and microdosimetric kinetic model implementation

Physics in Medicine & Biology, 2022
Abstract Objective. Since the early years, particle therapy treatments have been associated with concerns for late toxicities, especially secondary cancer risk (SCR). Nowadays, this concern is related to patients for whom long-term survival is expected (e.g. breast cancer, lymphoma, paediatrics).
Andrea Attili, Emanuele Scifoni, Francesco Tommasino   +2 more
openaire   +2 more sources

Dosimetric and Clinical Risk Factors for the Development of Maxillary Osteoradionecrosis in Adenoid Cystic Carcinoma (ACC) Patients Treated With Carbon Ion Radiotherapy

Frontiers in Oncology, 2022
BackgroundThe present study aims to evaluate dosimetric and clinical risk factors for the development of maxillary osteoradionecrosis (ORN) in head and neck adenoid cystic carcinoma (ACC) patients treated with carbon ion radiotherapy (CIRT ...
Barbara Vischioni, Stefania Russo, Martino Meuli, Maria Bonora, Sara Ronchi, Rossana Ingargiola, Anna Maria Camarda, Anna Maria Camarda, Sara Imparato, Lorenzo Preda, Lorenzo Preda, Lorenzo Preda, Mario Ciocca, Silvia Molinelli, Ester Orlandi   +14 more
doaj   +1 more source

Late normal tissue response in the rat spinal cord after carbon ion irradiation [PDF]

, 2018
Background: The present work summarizes the research activities on radiation-induced late effects in the rat spinal cord carried out within the “clinical research group ion beam therapy” funded by the German Research Foundation (DFG, KFO 214). Methods
Brons, Stephan, Debus, Jürgen, Grün, Rebecca, Huang, Lifi, Karger, Christian P., Peschke, Peter, Saager, Maria, Scholz, Michael, Welzel, Thomas   +8 more
core   +1 more source

Spot-Scanning Hadron Arc (SHArc) Therapy: A Study With Light and Heavy Ions

Advances in Radiation Oncology, 2021
Purpose: To evaluate the clinical potential of spot-scanning hadron arc (SHArc) therapy with a heavy-ion gantry. Methods and Materials: A series of in silico studies was conducted via treatment plan optimization in FRoG and the RayStation TPS to compare ...
Stewart Mein, PhD, Thomas Tessonnier, PhD, Benedikt Kopp, MS, Semi Harrabi, MD, Amir Abdollahi, MD, PhD, Jürgen Debus, MD, PhD, Thomas Haberer, PhD, Andrea Mairani, PhD   +7 more
doaj   +1 more source

Validation of the relative biological effectiveness of active-energy scanning carbon-ion radiotherapy on a commercial treatment planning system with a microdosimetic kinetic model

Radiation Oncology, 2023
Background The study objective was to validate the relative biological effectiveness (RBE) calculated by the modified microdosimetric kinetic model in RayStation (Ray-MKM) for active-energy scanning carbon-ion radiotherapy.
Weiwei Wang, Wei Sun, Hao Shen, Jingfang Zhao   +3 more
doaj   +1 more source

Biological Effects of Stellar Collapse Neutrinos [PDF]

, 1995
Massive stars in their final stages of collapse radiate most of their binding energy in the form of MeV neutrinos. The recoil atoms that they produce in elastic scattering off nuclei in organic tissue create radiation damage which is highly effective in ...
A. Drukier, D. M. Raup, D. Raup, D. T. Goodhead, D. T. Goodhead, J. Ellis, J. F. Ziegler, J. I. Collar, J. Kiefer, J. N. Bahcall, J. N. Bahcall, L. Sabatier, L. W. Brackenbusk, M. A. Kadhim, M. A. Ruderman, S. H. Jiang, S. M. Stanley, S. Z. Aghamohammadi, T. C. Yang, V. Michalik   +19 more
core   +2 more sources

Reproducing the NIRS-QST Clinical Dose Calculations for Carbon Ion Radiotherapy Using Microdosimetric Probability Density Distributions

Radiation
Ion radiotherapy requires accurate relative biological effectiveness (RBE) calculations to account for the markedly different biological effects of ions compared to photons.
Alessio Parisi, Keith M. Furutani, Shannon Hartzell, Chris J. Beltran   +3 more
doaj   +1 more source