Results 41 to 50 of about 15,118,660 (165)

Treatment planning for a scanned carbon beam with a modified microdosimetric kinetic model

Treatment planning for a scanned carbon beam with a modified microdosimetric kinetic model
We describe a method to calculate the relative biological effectiveness in mixed radiation fields of therapeutic ion beams based on the modified microdosimetric kinetic model (modified MKM). In addition, we show the procedure for integrating the modified MKM into a treatment planning system for a scanned carbon beam.
稲庭 拓, 458722, 松本 孔貴, 458707, 458709, Noda, Kouji, 458708, 松藤 成弘, Inaniwa, Taku, Furukawa, Takuji, 古澤 佳也, 458710, Matsufuji, Naruhiro, 458712, 458711, 458714, 458713, 458716, 458715, 458718, 458717, Kase, Yuuki, Furusawa, Yoshiya, 458719, 古川 卓司, Toshitou, Toshiyuki, 加瀬 優紀, Matsumoto, Yoshitaka, 歳藤 利行, 野田 耕司, 458721, 458720   +31 more
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Linking Microdosimetric Measurements to Biological Effectiveness in Ion Beam Therapy: A Review of Theoretical Aspects of MKM and Other Models

Frontiers in Physics, 2021
Different qualities of radiation are known to cause different biological effects at the same absorbed dose. Enhancements of the biological effectiveness are a direct consequence of the energy deposition clustering at the scales of DNA molecule and cell ...
V. E. Bellinzona, V. E. Bellinzona, F. Cordoni, F. Cordoni, M. Missiaggia, M. Missiaggia, F. Tommasino, F. Tommasino, E. Scifoni, C. La Tessa, C. La Tessa, A. Attili   +11 more
doaj   +1 more source

Analisi dei fondamenti fisici di modelli radiobiologici utilizzati in adroterapia [PDF]

, 2022
Studio dei modelli radiobiologici, microdosimetric kinetic model e loca effect model con confronto tra i due modelli e con i dati ...
D'Arsiè, Emilia
core  

Microdosimetry of diagnostic X-rays: applications of the variance-covariance method. [PDF]

, 1992
Microdosimetric measurements in beams of diagnostic X rays (between 30 and 125 kV) have been performed. In these pulsed radiation fields, microdosimetric measurements are possible only by application of the variance-covariance technique.
Kellerer, Albrecht M., Chen, J., Kellerer, A.M., Roos, H.   +3 more
core   +1 more source

Computation of microdosimetric distributions for small sites [PDF]

, 1977
Object of this study is the computation of microdosimetric functions for sites which are too small to permit experimental determination of the distributions by Rossi-counters.
Kellerer, Albrecht M., Chmelevsky, D.
core   +1 more source

Comparison of biophysical models with experimental data for three cell lines in response to irradiation with monoenergetic ions

Physics and Imaging in Radiation Oncology, 2019
The relative biological effectiveness (RBE) in particle therapy is currently estimated using biophysical models. We compared experimental measurements to the α curves as function of linear energy transfer computed by the Local Effect Model (LEM I-IV ...
Caterina Monini, Gersende Alphonse, Claire Rodriguez-Lafrasse, Étienne Testa, Michaël Beuve   +4 more
doaj   +1 more source

Clonogenic Survival RBE Calculations in Carbon Ion Therapy: The Importance of the Absolute Values of α and β in the Photon Dose-Response Curve and a Strategy to Mitigate Their Anticorrelation

Quantum Beam Science, 2023
The computation of the relative biological effectiveness (RBE) is a fundamental step in the planning of cancer radiotherapy treatments with accelerated ions.
Alessio Parisi, Chris J. Beltran, Keith M. Furutani   +2 more
doaj   +1 more source

Brainstem NTCP and Dose Constraints for Carbon Ion RT—Application and Translation From Japanese to European RBE-Weighted Dose

Frontiers in Oncology, 2020
Background and PurposeThe Italian National Center of Oncological Hadrontherapy (CNAO) has applied dose constraints for carbon ion RT (CIRT) as defined by Japan’s National Institute of Radiological Sciences (NIRS).
Jon Espen Dale, Jon Espen Dale, Silvia Molinelli, Barbara Vischioni, Viviana Vitolo, Maria Bonora, Giuseppe Magro, Andrea Mairani, Andrea Mairani, Azusa Hasegawa, Azusa Hasegawa, Tatsuya Ohno, Olav Dahl, Francesca Valvo, Piero Fossati, Piero Fossati   +15 more
doaj   +1 more source

Advancement of microdosimetric kinetic model in heavy-ion radiotherapy

Journal of Physics: Conference Series, 2020
Abstract To date, more than 11,000 cancer patients have been treated with therapeutic carbon-ion beams at the National Institute of Radiological Sciences (NIRS). In the treatment planning system, the biological effectiveness of the therapeutic carbon-ion beams has been predicted based on the microdosimetric kinetic (MK) model.
openaire   +1 more source

The microdosimetric extension in TOPAS: development and comparison with published data [PDF]

, 2019
Microdosimetric energy depositions have been suggested as a key variable for the modeling of the relative biological effectiveness (RBE) in proton and ion radiation therapy. However, microdosimetry has been underutilized in radiation therapy.
Rosenfeld, Anatoly B, McNamara, Aimee L, Faddegon, Bruce, Schuemann, Jan, Paganetti, Harald, Chen, Yizheng, Sung, Wonmo, Zhu, Hongyu, Li, Junli, Tran, Linh T, Burigo, Lucas N   +10 more
core   +1 more source