Results 31 to 40 of about 15,118,660 (165)

Carbon Ion Dose Constraints in the Head and Neck and Skull Base: Review of MedAustron Institutional Protocols [PDF]

International Journal of Particle Therapy, 2021
Background: Dose constraints are of paramount importance for the outcome of any radiotherapy treatment. In this article, we report dose-volume constraints as well as currently used fractionation schedules for carbon ion radiotherapy as applied in ...
Piero Fossati, MD, Ana Perpar, MD, Markus Stock, PhD, Petra Georg, MD, Antonio Carlino, PhD, Joanna Gora, PhD, Giovanna Martino, MSc, Eugen B. Hug, MD   +7 more
doaj   +1 more source

Implementation of simplified stochastic microdosimetric kinetic models into PHITS for application to radiation treatment planning

Implementation of simplified stochastic microdosimetric kinetic models into PHITS for application to radiation treatment planning
The stochastic microdosimetric kinetic (SMK) model is one of the most sophisticated and precise models used in the estimation of the relative biological effectiveness of carbon-ion radiotherapy (CRT) and boron neutron capture therapy (BNCT). However, because of its complicated and time-consuming calculation procedures, it is nearly impractical to ...
1017605, Hashimoto, Shintaro, 1017606, Taku, Inaniwa, Sato, Tatsuhiko, 1017610, Kumada, Hiroaki, 1017609, Inaniwa, Taku, 1017607, Takada, Kenta, 1017608   +11 more
openaire   +2 more sources

A Model for Estimating Dose-Rate Effects on Cell-Killing of Human Melanoma after Boron Neutron Capture Therapy

Cells, 2020
Boron neutron capture therapy (BNCT) is a type of radiation therapy for eradicating tumor cells through a 10B(n,α)7Li reaction in the presence of 10B in cancer cells.
Yusuke Matsuya, Hisanori Fukunaga, Motoko Omura, Hiroyuki Date   +3 more
doaj   +1 more source

Assessing the influence of microdosimetric formalism on calculations of relative biological effectiveness in carbon ion radiotherapy [PDF]

Precis Radiat Oncol
Precision Radiation Oncology, EarlyView.
Hartzell S, Furutani K, Parisi A, Sato T, Beltran C.   +4 more
europepmc   +2 more sources

Predicting the Biological Effects of Human Salivary Gland Tumour Cells for Scanned ⁴He-, ¹²C-, ¹⁶O-, and ²⁰Ne-Ion Beams Using an SOI Microdosimeter

Applied Sciences, 2022
Experimental microdosimetry along with the microdosimetric kinetic (MK) model can be utilized to predict the biological effects of ions. To predict the relative biological effectiveness (RBE) of ions and the survival fraction (SF) of human salivary gland
Sung Hyun Lee, Kota Mizushima, Shunsuke Yonai, Shinnosuke Matsumoto, Hideyuki Mizuno, Taku Nakaji, Ryosuke Kohno, Yoshiyuki Iwata, Toshiyuki Shirai, Vladimir Pan, Angela Kok, Marco Povoli, Linh T. Tran, Anatoly B. Rosenfeld, Masao Suzuki, Taku Inaniwa   +15 more
doaj   +1 more source

A novel system for micron-scale analysis of energy deposition and response to low-dose radiation. [PDF]

Med Phys
Abstract Background Micrometer‐scale evaluation of energy deposition is important for radiation protection and therapy as well as for advancing knowledge of responses to radiation in materials and biological systems. Due to the stochastic nature of radiation interactions, there is significant variation in energy deposition in micrometer‐sized targets ...
Pasricha P, McNairn C, Mansour IR, Milligan K, Muir BR, Andrews JL, Cassol E, Chauhan V, Subedi S, Jirasek A, Murugkar S, Thomson RM.   +11 more
europepmc   +2 more sources

Characterizing Radiation Effectiveness in Ion Beam Therapy Part I: Introduction and Biophysical Modeling of RBE Using the LEMIV

Frontiers in Physics, 2020
The specific advantages of ion beams for application in tumor therapy are attributed to their different macroscopic and microscopic energy deposition pattern as compared to conventional photon radiation.
Michael Scholz, Thomas Friedrich, Giulio Magrin, Paolo Colautti, Aleksandra Ristić-Fira, Ivan Petrović   +5 more
doaj   +1 more source

Across the stages: a multiscale extension of the generalized stochastic microdosimetric model (MS-GSM2) to include the ultra-high dose rate

Frontiers in Physics, 2023
Ultra-high dose rate (UHDR) irradiations with different types of radiation have shown a larger sparing of normal tissue and unchanged tumor control with respect to conventional delivery.
Marco Battestini, Marco Battestini, Marta Missiaggia, Andrea Attili, Francesco Tommasino, Francesco Tommasino, Chiara La Tessa, Francesco G. Cordoni, Francesco G. Cordoni, Emanuele Scifoni   +9 more
doaj   +1 more source

Measurement of microdosimetric spectra of high-LET particle beams using the ENCORE detector. [PDF]

Med Phys
Abstract Background Heavy ion radiotherapy offers distinct advantages over conventional treatments due to its superior dose distribution and enhanced biological effectiveness. However, the microdosimetric characteristics of high linear energy transfer (LET) ions, particularly near the Bragg peak, remain poorly characterized.
Hartzell S, Lopez-Saavedra E, Furutani KM, Almaraz-Calderon S, Baby LT, Wiedenhöver I, Beltran CJ.   +6 more
europepmc   +2 more sources

Calculating the relative biological effectiveness of carbon ion radiotherapy by common models using measurable microdosimetric inputs [PDF]

Precis Radiat Oncol
Precision Radiation Oncology, EarlyView.
Hartzell S, Guan F, Taylor P, Mirandola A, Magro G, Ciocca M, Kry S.   +6 more
europepmc   +2 more sources