Results 31 to 40 of about 1,371 (176)

Sensitivity study of the microdosimetric kinetic model parameters for carbon ion radiotherapy [PDF]

Physics in Medicine & Biology, 2018
In carbon ion therapy treatment planning, the relative biological effectiveness (RBE) is accounted for by optimization of the RBE-weighted dose (biological dose). The RBE calculation methods currently applied clinically in carbon ion therapy are derived from the microdosimetric kinetic model (MKM) in Japan and the local effect model (LEM) in Europe ...
T J Dahle, G Magro, K S Ytre-Hauge, C H Stokkevåg, K Choi, A Mairani   +5 more
openaire   +2 more sources

Characterizing Radiation Effectiveness in Ion Beam Therapy Part I: Introduction and Biophysical Modeling of RBE Using the LEMIV

Frontiers in Physics, 2020
The specific advantages of ion beams for application in tumor therapy are attributed to their different macroscopic and microscopic energy deposition pattern as compared to conventional photon radiation.
Michael Scholz, Thomas Friedrich, Giulio Magrin, Paolo Colautti, Aleksandra Ristić-Fira, Ivan Petrović   +5 more
doaj   +1 more source

Estimation of relative biological effectiveness for boron neutron capture therapy using the PHITS code coupled with a microdosimetric kinetic model. [PDF]

J Radiat Res, 2015
Horiguchi H, Sato T, Kumada H, Yamamoto T, Sakae T.   +4 more
europepmc   +2 more sources

Linking Microdosimetric Measurements to Biological Effectiveness in Ion Beam Therapy: A Review of Theoretical Aspects of MKM and Other Models

Frontiers in Physics, 2021
Different qualities of radiation are known to cause different biological effects at the same absorbed dose. Enhancements of the biological effectiveness are a direct consequence of the energy deposition clustering at the scales of DNA molecule and cell ...
V. E. Bellinzona, V. E. Bellinzona, F. Cordoni, F. Cordoni, M. Missiaggia, M. Missiaggia, F. Tommasino, F. Tommasino, E. Scifoni, C. La Tessa, C. La Tessa, A. Attili   +11 more
doaj   +1 more source

A Monte Carlo approach to the microdosimetric kinetic model to account for dose rate time structure effects in ion beam therapy with application in treatment planning simulations [PDF]

Medical Physics, 2017
Attili, A., Cirio, Roberto, Dalmasso, Federico, Giordanengo, S, Manganaro, Lorenzo, Monaco, Vincenzo, Muraro, S, Russo, G, Sacchi, Roberto, Vignati, A   +9 more
core   +3 more sources

Radially restricted linear energy transfer for high-energy protons: A new analytical approach [PDF]

, 1994
Radially restricted linear energy transfer (LET) is a basic physical parameter relevant to radiation biology and radiation protection. In this report a convenient method is presented for the analytical computation of this quantity without the need for ...
A Chatterjee, A Chatterjee, A Cole, A. M. Kellerer, AM Kellerer, H. H. Rossi, J. Chen, M Inokuti, M Rudd, M Zaider, MA Xapsos, MPR Waligorski   +11 more
core   +1 more source

Comparison of biophysical models with experimental data for three cell lines in response to irradiation with monoenergetic ions

Physics and Imaging in Radiation Oncology, 2019
The relative biological effectiveness (RBE) in particle therapy is currently estimated using biophysical models. We compared experimental measurements to the α curves as function of linear energy transfer computed by the Local Effect Model (LEM I-IV ...
Caterina Monini, Gersende Alphonse, Claire Rodriguez-Lafrasse, Étienne Testa, Michaël Beuve   +4 more
doaj   +1 more source

A generalized definition of dosimetric quantities [PDF]

, 1990
The current definitions of microdosimetric and dosimetric quantities use the notion of 'ionizing radiation'. However, this notion is not rigorously defined, and its definition would require the somewhat arbitrary choice of specified energy cut-off values
A.M. Kellerer, Alm-Carlsson G, Caswell R.S., H.H. Rossi, ICRU, ICRU, ICRU, ICRU, ICRU, Roesch W.C, Spencer L.V   +10 more
core   +1 more source

Clonogenic Survival RBE Calculations in Carbon Ion Therapy: The Importance of the Absolute Values of α and β in the Photon Dose-Response Curve and a Strategy to Mitigate Their Anticorrelation

Quantum Beam Science, 2023
The computation of the relative biological effectiveness (RBE) is a fundamental step in the planning of cancer radiotherapy treatments with accelerated ions.
Alessio Parisi, Chris J. Beltran, Keith M. Furutani   +2 more
doaj   +1 more source

Concepts of microdosimetry [PDF]

, 1975
This is the first part of an investigation of microdosimetric concepts relevant to numerical calculations. The definitions of the microdosimetric quantities are reviewed and formalized, and some additional conventions are adopted.
A. Chatterjee, A. M. Kellerer, A. M. Kellerer, A. M. Kellerer, A. M. Kellerer, A. M. Kellerer, A. M. Kellerer, D. Chmelevsky, H. H. Rossi, H. H. Rossi, ICRU, ICRU, M. G. Kendall, M. N. Varma, R. S. Caswell, W. A. Glass   +15 more
core   +3 more sources