Results 21 to 30 of about 15,118,660 (165)

Adaptation of the microdosimetric kinetic model to hypoxia

Adaptation of the microdosimetric kinetic model to hypoxia
Ion beams present a potential advantage in terms of treatment of lesions with hypoxic regions. In order to use this potential, it is important to accurately model the cell survival of oxic as well as hypoxic cells. In this work, an adaptation of the microdosimetric kinetic (MK) model making it possible to account for cell hypoxia is presented.
Matsufuji, Naruhiro, 稲庭 拓, 松藤 成弘, Inaniwa, Taku, Kitagawa, Atsushi, Noda, Koji, 北川 敦志, 平山 亮一, 477727, 477728, 477729, 477734, Hirayama, Ryoichi, 477735, 477736, 477726, Ｂｏｐｐ Ｃｅｃｉｌｅ, 477737, 477730, 477731, 野田 耕司, 477732, Cecile, Bopp, 477733   +23 more
openaire   +2 more sources

Linear energy transfer optimization mitigates biological model discrepancies in carbon ion radiotherapy for pelvic osteosarcoma [PDF]

Physics and Imaging in Radiation Oncology
Background and purpose: In the combined treatment of osteosarcoma with a carbon ion radiotherapy (CIRT) boost, large pelvic tumors are associated with significantly lower tumor control compared to craniofacial localization.
Natalia Sycheva, Katharina Kozyra, Katharina Seidensaal, Hanna Waldsperger, Semi B. Harrabi, Jürgen Debus, Andrea Mairani, Thomas Tessonnier   +7 more
doaj   +2 more sources

Advancement of microdosimetric kinetic model in heavy-ion radiotherapy

Advancement of microdosimetric kinetic model in heavy-ion radiotherapy
To date, more than 11,000 cancer patients have been treated with therapeutic carbon-ion beams at the National Institute of Radiological Sciences (NIRS). In the treatment planning system, the biological effectiveness of the therapeutic carbon-ion beams has been predicted based on the microdosimetric kinetic (MK) model.
893190, Inaniwa, Taku, 893191
openaire   +2 more sources

The Mayo Clinic Florida Microdosimetric Kinetic Model of Clonogenic Survival: Application to Various Repair-Competent Rodent and Human Cell Lines. [PDF]

Int J Mol Sci, 2022
The relative biological effectiveness (RBE) calculations used during the planning of ion therapy treatments are generally based on the microdosimetric kinetic model (MKM) and the local effect model (LEM).
Parisi A, Beltran CJ, Furutani KM.
europepmc   +2 more sources

The Estimated Difference in Biologically Effective Dose Between Two-Opposing-Fields-Per-Day and One-Alternating-Field-Per-Day Carbon Ion Radiation Therapy for Prostate Cancer [PDF]

Advances in Radiation Oncology
Purpose: This study aims to determine whether two-opposing-fields-per-day (2-fields-per-day) carbon ion radiation therapy for prostate cancer provides a significant advantage in terms of biologically effective dose (BED) for normal tissue compared to the
Chi-Chuan Chiou, MD, Yu-Ming Liu, PhD, Keng-Li Lan, PhD, Yuan-Hung Wu, PhD, Tzu-Yu Lai, PhD, Yu-Mei Kang, MD, Jui-Pin Chen, MSc, Yu-Wen Hu, PhD   +7 more
doaj   +2 more sources

Comparative evaluation of the Mayo Clinic Florida microdosimetric kinetic model and mMKM for carbon ion treatment planning: A matRad-based analysis. [PDF]

J Appl Clin Med Phys
Abstract Purpose Modeling relative biological effectiveness (RBE) is central to carbon ion radiotherapy treatment planning. The modified Microdosimetric Kinetic Model (mMKM) is a clinically established RBE framework that has guided treatment protocols at many existing carbon centers, while the Mayo Clinic Florida Microdosimetric Kinetic Model (MCF MKM)
Hartzell S, Yaddanapudi S, Furutani KM, Parisi A, Liang X, Park C, Lu B, Tan J, Seckler L, Cristoforetti R, Inaniwa T, Wahl N, Beltran CJ.   +12 more
europepmc   +2 more sources

Vision and implementation for the first U.S. carbon ion therapy center part I: Clinical rationale and the need for CIRT in the United States. [PDF]

J Appl Clin Med Phys
Abstract Carbon ion radiotherapy (CIRT) has evolved into an established clinical modality over the past three decades. Owing to its unique physical and biological characteristics, CIRT has demonstrated favorable outcomes for selected malignancies characterized by radioresistance, proximity to critical organs, locally advanced disease requiring safe ...
Liang X, Beltran CJ.
europepmc   +2 more sources

Cell survival comparison of proton, helium, and carbon ion interlaced minibeams in water phantom simulations. [PDF]

Med Phys
Abstract Background Radiotherapy is a key in cancer treatment, with particle therapy providing better tumor targeting and sparing healthy tissues. Particle Minibeam Radiotherapy (PMBT) integrates the advantages of spatial fractionation into particle radiotherapy by employing submillimeter‐sized beams, thus improving the therapeutic ratio by reducing ...
Rousseti A, Dollinger G, Reindl J.
europepmc   +2 more sources

Vision and implementation for the first U.S. carbon ion therapy center part II: Design philosophy and clinical implementation. [PDF]

J Appl Clin Med Phys
Abstract The anticipated clinical demand for carbon ion radiotherapy (CIRT) in the United States is expected to include a substantial proportion of clinically complex disease sites that require accurate, highly conformal, and adaptive treatment. These clinical needs, together with the unique physical and biological characteristics of carbon ion beams ...
Liang X, Beltran CJ.
europepmc   +2 more sources

First theoretical determination of relative biological effectiveness of very high energy electrons

Scientific Reports, 2021
Very high energy electrons (VHEEs, E > 70 MeV) present promising clinical advantages over conventional beams due to their increased range, improved penumbra and relative insensitivity to tissue heterogeneities.
Rachel Delorme, Thongchai A. M. Masilela, Camille Etoh, François Smekens, Yolanda Prezado   +4 more
doaj   +1 more source