Mathematical model combined with microdosimetric kinetic model for tumor volume calculation in stereotactic body radiation therapy [PDF]
Scientific Reports, 2023 We proposed a new mathematical model that combines an ordinary differential equation (ODE) and microdosimetric kinetic model (MKM) to predict the tumor-cell lethal effect of Stereotactic body radiation therapy (SBRT) applied to non-small cell lung cancer
Hisashi Nakano +7 more
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Individual dosimetry system for targeted alpha therapy based on PHITS coupled with microdosimetric kinetic model [PDF]
EJNMMI Physics, 2021 Background An individual dosimetry system is essential for the evaluation of precise doses in nuclear medicine. The purpose of this study was to develop a system for calculating not only absorbed doses but also EQDX(α/β) from the PET-CT images of ...
Tatsuhiko Sato +6 more
doaj +5 more sources
Modelling Dose Effects from Space Irradiations: Combination of High-LET and Low-LET Radiations with a Modified Microdosimetric Kinetic Model [PDF]
Life, 2020 The Microdosimetric Kinetic Model (MKM) to predict the effects of ionizing radiation on cell colonies is studied and reformulated for the case of high-linear energy transfer (LET) radiations with a low dose.
Alejandro Bertolet, Alejandro Carabe
doaj +2 more sources
RBE-weighted dose conversions for patients with recurrent nasopharyngeal carcinoma receiving carbon-ion radiotherapy from the local effect model to the microdosimetric kinetic model [PDF]
Radiation Oncology, 2020 Background We sought to establish a conversion curve to convert the RBE-weighted doses calculated by local effect model I (LEM) (LEM RBE-weighted doses) in patients with locally recurrent nasopharyngeal carcinoma (rNPC) to the RBE-weighted doses ...
Liwen Zhang +4 more
doaj +2 more sources
Biological dosimetric impact of dose-delivery time for hypoxic tumour with modified microdosimetric kinetic model [PDF]
Reports of Practical Oncology and Radiotherapy, 2023 An improved microdosimetric kinetic model (MKM) can address radiobiological effects with prolonged delivery times. However, these do not consider the effects of oxygen. The current study aimed to evaluate the biological dosimetric effects associated with the dose delivery time in hypoxic tumours with improved MKM for photon radiation therapy.Cell ...
Kawahara, Daisuke, Nagata, Yasushi
europepmc +3 more sources
A standardized measurement-based approach to estimate modelled relative biological effectiveness for auditing carbon ion beams [PDF]
Physics and Imaging in Radiation OncologyBackground and purpose: Differences in dose delivered during carbon radiotherapy are due largely to variations in relative biological effectiveness (RBE), which can be calculated by several models.
Shannon Hartzell +8 more
doaj +2 more sources
Effect of dose-delivery time for flattened and flattening filter-free photon beams based on microdosimetric kinetic model. [PDF]
PLoS ONE, 2018 The effect of dose-delivery time with flattening filter (FF) and flattening filter-free (FFF) photon beams based on microdosimetric kinetic model (MKM) was investigated in this study.
Hisashi Nakano +4 more
doaj +2 more sources
Design, implementation, and assessment of an independent second-check system for proton and carbon-ion pencil-beam scanning: delivery-aware Monte Carlo and microdosimetric RBE-weighted dose [PDF]
Frontiers in OncologyBackgroundIndependent second checks for proton and carbon-ion pencil-beam scanning should assess the planned physical dose, the expected delivery sequence, and the model-dependent relative biological effectiveness (RBE)-weighted dose.ObjectiveThe aim of ...
Jun Tan +4 more
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Quantitative estimation of DNA damage by photon irradiation based on the microdosimetric-kinetic model. [PDF]
J Radiat Res, 2014 The microdosimetric-kinetic (MK) model is one of the models that can describe the fraction of cells surviving after exposure to ionizing radiation. In the MK model, there are specific parameters, k and yD, where k is an inherent parameter to represent the number of potentially lethal lesions (PLLs) and yD indicates the dose-mean lineal energy in keV/μm.
Matsuya Y +5 more
europepmc +5 more sources
Revisiting fractionation in prostate carbon ion therapy: first comparative analysis of biologically effective dose using mMKM with diverse parameters [PDF]
Radiation OncologyBackground Carbon ion radiotherapy (CIRT) for prostate cancer has evolved from conventional regimens [66 Gy(RBE)/20 fractions (66G20), 63 Gy(RBE)/20 fractions (63G20)] toward hypofractionated schedules [57.6 Gy(RBE)/16 fractions (57.6G16), 51.6 Gy(RBE ...
Chi-Chuan Chiou +7 more
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