Mathematical model combined with microdosimetric kinetic model for tumor volume calculation in stereotactic body radiation therapy [PDF]
Scientific Reports, 2023 We proposed a new mathematical model that combines an ordinary differential equation (ODE) and microdosimetric kinetic model (MKM) to predict the tumor-cell lethal effect of Stereotactic body radiation therapy (SBRT) applied to non-small cell lung cancer
Hisashi Nakano +7 more
doaj +6 more sources
Individual dosimetry system for targeted alpha therapy based on PHITS coupled with microdosimetric kinetic model [PDF]
EJNMMI Physics, 2021 Background An individual dosimetry system is essential for the evaluation of precise doses in nuclear medicine. The purpose of this study was to develop a system for calculating not only absorbed doses but also EQDX(α/β) from the PET-CT images of ...
Tatsuhiko Sato +6 more
doaj +5 more sources
Modelling Dose Effects from Space Irradiations: Combination of High-LET and Low-LET Radiations with a Modified Microdosimetric Kinetic Model [PDF]
Life, 2020 The Microdosimetric Kinetic Model (MKM) to predict the effects of ionizing radiation on cell colonies is studied and reformulated for the case of high-linear energy transfer (LET) radiations with a low dose.
Alejandro Bertolet, Alejandro Carabe
doaj +5 more sources
Quantitative estimation of DNA damage by photon irradiation based on the microdosimetric-kinetic model. [PDF]
J Radiat Res, 2014 The microdosimetric-kinetic (MK) model is one of the models that can describe the fraction of cells surviving after exposure to ionizing radiation. In the MK model, there are specific parameters, k and yD, where k is an inherent parameter to represent the number of potentially lethal lesions (PLLs) and yD indicates the dose-mean lineal energy in keV/μm.
Matsuya Y +5 more
europepmc +7 more sources
Biological dosimetric impact of dose-delivery time for hypoxic tumour with modified microdosimetric kinetic model [PDF]
Reports of Practical Oncology and Radiotherapy, 2023 An improved microdosimetric kinetic model (MKM) can address radiobiological effects with prolonged delivery times. However, these do not consider the effects of oxygen. The current study aimed to evaluate the biological dosimetric effects associated with the dose delivery time in hypoxic tumours with improved MKM for photon radiation therapy.Cell ...
Kawahara, Daisuke, Nagata, Yasushi
europepmc +3 more sources
RBE-weighted dose conversions for patients with recurrent nasopharyngeal carcinoma receiving carbon-ion radiotherapy from the local effect model to the microdosimetric kinetic model [PDF]
Radiation Oncology, 2020 Background We sought to establish a conversion curve to convert the RBE-weighted doses calculated by local effect model I (LEM) (LEM RBE-weighted doses) in patients with locally recurrent nasopharyngeal carcinoma (rNPC) to the RBE-weighted doses ...
Liwen Zhang +4 more
doaj +2 more sources
Effect of dose-delivery time for flattened and flattening filter-free photon beams based on microdosimetric kinetic model. [PDF]
PLoS ONE, 2018 The effect of dose-delivery time with flattening filter (FF) and flattening filter-free (FFF) photon beams based on microdosimetric kinetic model (MKM) was investigated in this study.
Hisashi Nakano +4 more
doaj +2 more sources
A novel system for micron-scale analysis of energy deposition and response to low-dose radiation. [PDF]
Med PhysAbstract Background Micrometer‐scale evaluation of energy deposition is important for radiation protection and therapy as well as for advancing knowledge of responses to radiation in materials and biological systems. Due to the stochastic nature of radiation interactions, there is significant variation in energy deposition in micrometer‐sized targets ...
Pasricha P +11 more
europepmc +2 more sources
Revisiting fractionation in prostate carbon ion therapy: first comparative analysis of biologically effective dose using mMKM with diverse parameters [PDF]
Radiation OncologyBackground Carbon ion radiotherapy (CIRT) for prostate cancer has evolved from conventional regimens [66 Gy(RBE)/20 fractions (66G20), 63 Gy(RBE)/20 fractions (63G20)] toward hypofractionated schedules [57.6 Gy(RBE)/16 fractions (57.6G16), 51.6 Gy(RBE ...
Chi-Chuan Chiou +7 more
doaj +2 more sources
Measurement of microdosimetric spectra of high-LET particle beams using the ENCORE detector. [PDF]
Med PhysAbstract Background Heavy ion radiotherapy offers distinct advantages over conventional treatments due to its superior dose distribution and enhanced biological effectiveness. However, the microdosimetric characteristics of high linear energy transfer (LET) ions, particularly near the Bragg peak, remain poorly characterized.
Hartzell S +6 more
europepmc +2 more sources