Results 11 to 20 of about 1,371 (176)

Validation of the physical and RBE-weighted dose estimator based on PHITS coupled with a microdosimetric kinetic model for proton therapy. [PDF]

J Radiat Res, 2018
The microdosimetric kinetic model (MKM) is widely used for estimating relative biological effectiveness (RBE)-weighted doses for various radiotherapies because it can determine the surviving fraction of irradiated cells based on only the lineal energy ...
Takada K, Sato T, Kumada H, Koketsu J, Takei H, Sakurai H, Sakae T.   +6 more
europepmc   +5 more sources

Predicting the Biological Effects of Human Salivary Gland Tumour Cells for Scanned ⁴He-, ¹²C-, ¹⁶O-, and ²⁰Ne-Ion Beams Using an SOI Microdosimeter [PDF]

Applied Sciences, 2022
Experimental microdosimetry along with the microdosimetric kinetic (MK) model can be utilized to predict the biological effects of ions. To predict the relative biological effectiveness (RBE) of ions and the survival fraction (SF) of human salivary gland
Sung Hyun Lee, Kota Mizushima, Shunsuke Yonai, Shinnosuke Matsumoto, Hideyuki Mizuno, Taku Nakaji, Ryosuke Kohno, Yoshiyuki Iwata, Toshiyuki Shirai, Vladimir Pan, Angela Kok, Marco Povoli, Linh T. Tran, Anatoly B. Rosenfeld, Masao Suzuki, Taku Inaniwa   +15 more
doaj   +3 more sources

Equivalent relative biological effectiveness for cell survival and micronuclei formation: insights from a biophysical approach. [PDF]

Med Phys
Abstract Background Micronuclei (MN), which are chromosome fragments, are formed after exposure to ionizing radiation. Radiation‐induced MN is currently used as a quantitative indicator of the chromosomal aberrations detectable at a relatively early phase (e.g., within one cell‐cycle progression).
Matsuya Y, Saga R, Wang Y, Sato T.
europepmc   +2 more sources

Improved dose compensation model owing to short irradiation interruption time for hypoxic tumor using a microdosimetric kinetic model. [PDF]

Rep Pract Oncol Radiother
The objective was to enhance the biological compensation factor related to irradiation interruption in a short time (short irradiation interruption) in hypoxic tumors using a refined microdosimetric kinetic model (MKM) for photon radiation therapy.The biological dose differences were calculated for CHO-K1 cells exposed to a photon beam, considering ...
Kawahara D.
europepmc   +3 more sources

Generality Assessment of a Model Considering Heterogeneous Cancer Cells for Predicting Tumor Control Probability for Stereotactic Body Radiation Therapy Against Non-Small Cell Lung Cancer [PDF]

Advances in Radiation Oncology
The generality of a model for predicting tumor control probability from in vitro clonogenic survival considering of cancer stem-like cells, the so-called integrated microdosimetric-kinetic model, is presented by comparing the model to public data on ...
Ryo Saga, PhD, Yusuke Matsuya, PhD, Hideki Obara, PhD, Fumio Komai, MS, Hironori Yoshino, PhD, Masahiko Aoki, PhD, MD, Yoichiro Hosokawa, PhD, DDS   +6 more
doaj   +2 more sources

Evaluation of relative biological effectiveness of 225Ac and its decay daughters with Monte Carlo track structure simulations [PDF]

EJNMMI Physics
Background 225Ac is a radionuclide that can be utilized in targeted alpha therapy (TAT). To accurately assess the absorbed dose and radiation effects in TAT, it is necessary to calculate the relative biological effectiveness (RBE).
Ziyi Hu, Shuiyin Qu, Hongming Liu, Yunhao Zhang, Shuchang Yan, Ankang Hu, Rui Qiu, Zhen Wu, Hui Zhang, Junli Li   +9 more
doaj   +2 more sources

Variation of the relative biological effectiveness in the penumbra of ion therapy beams estimated using different microdosimetric approaches [PDF]

Physics and Imaging in Radiation Oncology
Background and Purpose: The effort to translate clinical findings across institutions employing different relative biological effectiveness (RBE) models of ion radiotherapy has rapidly grown in recent years.
Alessio Parisi, Keith M. Furutani, Chris J. Beltran   +2 more
doaj   +2 more sources

'Dirty dose'-based proton variable RBE models - performance assessment on in vitro data. [PDF]

Med Phys
Abstract Background In clinical proton radiotherapy, a constant relative biological effectiveness (RBE) of 1.1 is typically applied. Due to abundant evidence of variable RBE effects from in vitro data, multiple variable RBE models have been suggested, typically by describing the α$\alpha$ and β$\beta$ parameters in the linear quadratic (LQ) model as a ...
Kalholm F, Toma-Dasu I, Traneus E.
europepmc   +2 more sources

LET measurements in proton and helium-ion beams of therapeutic energies using a silicon pixel detector towards a tool for quality assurance. [PDF]

Med Phys
Abstract Background As advanced treatment plans increasingly include optimizing both dose and linear energy transfer (LET), there is a growing demand for tools to measure LET in clinical settings. Although various detection systems have been investigated in this pursuit, the scarcity of detectors capable of providing per‐ion data for a fast and ...
Hamad Y, Sari FK, Félix-Bautista R, Martišíková M, Mairani A, Gehrke T.   +5 more
europepmc   +2 more sources

The Estimated Difference in Biologically Effective Dose Between Two-Opposing-Fields-Per-Day and One-Alternating-Field-Per-Day Carbon Ion Radiation Therapy for Prostate Cancer [PDF]

Advances in Radiation Oncology
Purpose: This study aims to determine whether two-opposing-fields-per-day (2-fields-per-day) carbon ion radiation therapy for prostate cancer provides a significant advantage in terms of biologically effective dose (BED) for normal tissue compared to the
Chi-Chuan Chiou, MD, Yu-Ming Liu, PhD, Keng-Li Lan, PhD, Yuan-Hung Wu, PhD, Tzu-Yu Lai, PhD, Yu-Mei Kang, MD, Jui-Pin Chen, MSc, Yu-Wen Hu, PhD   +7 more
doaj   +2 more sources