Results 11 to 20 of about 15,118,660 (165)

Improved dose compensation model owing to short irradiation interruption time for hypoxic tumor using a microdosimetric kinetic model. [PDF]

Rep Pract Oncol Radiother
The objective was to enhance the biological compensation factor related to irradiation interruption in a short time (short irradiation interruption) in hypoxic tumors using a refined microdosimetric kinetic model (MKM) for photon radiation therapy.The biological dose differences were calculated for CHO-K1 cells exposed to a photon beam, considering ...
Kawahara D.
europepmc   +5 more sources

pyMKM: An Open-Source Python Package for Microdosimetric Kinetic Model Calculation in Research and Clinical Applications

Computation
Among existing radiobiological models, the MKM and its extensions (SMK and OSMK) have demonstrated strong predictive capabilities but remain computationally demanding.
Giuseppe Magro, Vittoria Pavanello, Yihan Jia, Loïc Grevillot, Lars Glimelius, Andrea Mairani   +5 more
doaj   +4 more sources

Reproducing the NIRS-QST Clinical Dose Calculations for Carbon Ion Radiotherapy Using Microdosimetric Probability Density Distributions

Radiation
Ion radiotherapy requires accurate relative biological effectiveness (RBE) calculations to account for the markedly different biological effects of ions compared to photons.
Alessio Parisi, Keith M. Furutani, Shannon Hartzell, Chris J. Beltran   +3 more
doaj   +2 more sources

Sensitivity study of the microdosimetric kinetic model parameters for carbon ion radiotherapy [PDF]

Physics in Medicine & Biology, 2018
Abstract In carbon ion therapy treatment planning, the relative biological effectiveness (RBE) is accounted for by optimization of the RBE-weighted dose (biological dose). The RBE calculation methods currently applied clinically in carbon ion therapy are derived from the microdosimetric kinetic model (MKM) in ...
T J Dahle, G Magro, K S Ytre-Hauge, C H Stokkevåg, K Choi, A Mairani   +5 more
openaire   +4 more sources

Impact of Microdosimetric Modeling on Computation of Relative Biological Effectiveness for Carbon Ion Radiotherapy

Radiation
Microdosimetry plays a critical role in particle therapy by quantifying energy deposition within microscopic domains to assess biological effects. This study evaluates the influence of different microdosimetric functions (MFs) and domain geometries (DGs)
Shannon Hartzell, Keith M. Furutani, Alessio Parisi, Tatsuhiko Sato, Yuki Kase, Christian Deglow, Thomas Friedrich, Chris J. Beltran   +7 more
doaj   +2 more sources

Generality Assessment of a Model Considering Heterogeneous Cancer Cells for Predicting Tumor Control Probability for Stereotactic Body Radiation Therapy Against Non-Small Cell Lung Cancer

Advances in Radiation Oncology
The generality of a model for predicting tumor control probability from in vitro clonogenic survival considering of cancer stem-like cells, the so-called integrated microdosimetric-kinetic model, is presented by comparing the model to public data on ...
Ryo Saga, PhD, Yusuke Matsuya, PhD, Hideki Obara, PhD, Fumio Komai, MS, Hironori Yoshino, PhD, Masahiko Aoki, PhD, MD, Yoichiro Hosokawa, PhD, DDS   +6 more
doaj   +2 more sources

Biological Dose Estimation for Charged-Particle Therapy Using an Improved PHITS Code Coupled With a Microdosimetric Kinetic Model

Radiation Research, 2009
Microdosimetric quantities such as lineal energy, y, are better indexes for expressing the RBE of HZE particles in comparison to LET. However, the use of microdosimetric quantities in computational dosimetry is severely limited because of the difficulty ...
Tatsuhiko Sato, Lembit Sihver, Koji Niita   +2 more
exaly   +2 more sources

Evaluation of relative biological effectiveness of 225Ac and its decay daughters with Monte Carlo track structure simulations [PDF]

EJNMMI Physics
Background 225Ac is a radionuclide that can be utilized in targeted alpha therapy (TAT). To accurately assess the absorbed dose and radiation effects in TAT, it is necessary to calculate the relative biological effectiveness (RBE).
Ziyi Hu, Shuiyin Qu, Hongming Liu, Yunhao Zhang, Shuchang Yan, Ankang Hu, Rui Qiu, Zhen Wu, Hui Zhang, Junli Li   +9 more
doaj   +2 more sources

Variation of the relative biological effectiveness in the penumbra of ion therapy beams estimated using different microdosimetric approaches

Physics and Imaging in Radiation Oncology
Background and Purpose: The effort to translate clinical findings across institutions employing different relative biological effectiveness (RBE) models of ion radiotherapy has rapidly grown in recent years.
Alessio Parisi, Keith M. Furutani, Chris J. Beltran   +2 more
doaj   +2 more sources

A systematic analysis of the particle irradiation data ensemble in the key of the microdosimetric kinetic model: Should clonogenic data be used for clinical relative biological effectiveness? [PDF]

Radiother Oncol, 2023
Suárez-García D, Cortés-Giraldo MA, Bertolet A.   +2 more
europepmc   +2 more sources