Results 11 to 20 of about 575,565 (246)
Medicina, 2019 Background and Objectives: The tumor microenvironment has been widely implicated in tumorigenesis because it harbors tumor cells that interact with surrounding cells through the circulatory and lymphatic systems to influence the development and progression of cancer.
Arneth, Borros +1 more
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Human hematopoietic microenvironments [PDF]
PLOS ONE, 2021 Dormancy of hematopoietic stem cells and formation of progenitors are directed by signals that come from the bone marrow microenvironment. Considerable knowledge has been gained on the murine hematopoietic stem cell microenvironment, while less so on the murine progenitor microenvironment and even less so on these microenvironments in humans ...
Helene Bjoerg Kristensen +7 more
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Firing up the cold tumors by targeting Vps34
OncoImmunology, 2020 Cancer immunotherapy based on anti-PD-1/PD-L1 blockade is particularly effective in responding to patients with hot tumors. These tumors are characterized by the accumulation of proinflammatory cytokines and T cell infiltration.
Bassam Janji +4 more
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Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
Nature Communications, 2021 The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can ...
Jianhuang Lin +13 more
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Tumor microenvironment antigens [PDF]
Seminars in Immunopathology, 2022 AbstractThe identification and characterization of tumor antigens are central objectives in developing anti-cancer immunotherapy. Traditionally, tumor-associated antigens (TAAs) are considered relatively restricted to tumor cells (i.e., overexpressed proteins in tumor cells), whereas tumor-specific antigens (TSAs) are considered unique to tumor cells ...
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Oncogenesis, 2023 Advanced cutaneous melanoma is the deadliest form of skin cancer and one of the most aggressive human cancers. Targeted therapies (TT) against BRAF mutated melanoma and immune checkpoints blockade therapies (ICB) have been a breakthrough in the treatment
Serena Diazzi +2 more
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Hepatology Communications, 2020 Transforming growth factor β (TGFβ) induces hepatic stellate cell (HSC) differentiation into tumor‐promoting myofibroblast, although underlying mechanism remains incompletely understood.
Yunru Chen +10 more
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Optimized exosome isolation protocol for cell culture supernatant and human plasma [PDF]
Journal of Extracellular Vesicles, 2015 Extracellular vesicles represent a rich source of novel biomarkers in the diagnosis and prognosis of disease. However, there is currently limited information elucidating the most efficient methods for obtaining high yields of pure exosomes, a subset of ...
Richard J. Lobb +6 more
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Indian Journal of Medical and Paediatric Oncology, 2020 A tumor is not simply a group of cancer cells, but rather a heterogeneous collection of infiltrating and resident host cells, secreted factors and extracellular matrix. Tumor cells stimulate significant molecular, cellular and physical changes within their host tissues to support tumor growth and progression.
Azgar Abdul Rasheed +1 more
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Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Signal Transduction and Targeted Therapy, 2023 Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide. OA was believed to be caused by the wearing and tearing of articular cartilage, but it is now more commonly ...
Qing Yao +9 more
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