Results 11 to 20 of about 16,295 (141)
Villin: The major microfilament-associated protein of the intestinal microvillus [PDF]
Proceedings of the National Academy of Sciences, 1979 The major protein associated with actin in the microfilament core of intestinal microvilli has been purified. This protein, for which we propose the name villin, has a polypeptide molecular weight of approximately 95,000. Two arguments suggest that villin may be the microvillus crossfilament protein that links the microfilament core laterally down its ...
A, Bretscher, K, Weber
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The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
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Modulation of Microfilament Protein Composition by Transfected Cytoskeletal Actin Genes [PDF]
Molecular and Cellular Biology, 1988 HuT-14T is a highly tumorigenic fibroblast cell line which exhibits a reduced steady-state level of beta-actin due to coding mutations in one of two beta-actin alleles. The normal rate of total actin synthesis could be restored in some clones of cells following transfection of the functional beta-actin gene but not following transfection of the ...
S Y, Ng +4 more
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Dephosphorylated but not phosphorylated microtubule associated protein MAP1B binds to microfilaments [PDF]
FEBS Letters, 1996 We have reported that purified native MAP1B interacts with microtubules but not with microfilaments [Pedrotti and Islam, Cell Motil. Cytoskel. (1995) 30, 301–309]. However, MAP1B can be phosphorylated at multiple sites by casein kinase II (CKII) and proline‐directed protein kinases (PDPK) and immunoblotting studies show that purified native MAP1B is ...
Pedrotti, Barbara, Islam, Khalid
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Characterization of Human Palladin, a Microfilament-associated Protein
Molecular Biology of the Cell, 2001 Actin-containing microfilaments control cell shape, adhesion, and contraction. In striated muscle, α-actinin and other Z-disk proteins coordinate the organization and functions of actin filaments. In smooth muscle and nonmuscle cells, periodic structures termed dense bodies and dense regions, respectively, are thought to serve functions analogous to Z ...
O M, Mykkänen +6 more
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Gas2, a growth arrest-specific protein, is a component of the microfilament network system [PDF]
The Journal of cell biology, 1992 In this report we analyze the protein product of a growth arrest-specific gene, gas2, by means of an affinity-purified antibody raised against the protein produced in bacteria. The regulation of Gas2 biosynthesis reflects the pattern of mRNA expression (Schneider, C., R. King, and L. Philipson. 1988. Cell.
BRANCOLINI, Claudio +2 more
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An Essential Cytoskeletal Linker Protein Connecting Actin Microfilaments to Intermediate Filaments [PDF]
Cell, 1996 Typified by rapid degeneration of sensory neurons, dystonia musculorum mice have a defective BPAG1 gene, known to be expressed in epidermis. We report a neuronal splice form, BPAG1n, which localizes to sensory axons. Both isoforms have a coiled-coil rod, followed by a carboxy domain that associates with intermediate filaments.
Yang, Y. +5 more
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Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins [PDF]
The Journal of Cell Biology, 2001 By screening a yeast two-hybrid library with COOH-terminal fragments of vinculin/metavinculin as the bait, we identified a new protein termed raver1. Raver1 is an 80-kD multidomain protein and widely expressed but to varying amounts in different cell lines. In situ and in vitro, raver1 forms complexes with the microfilament-associated proteins vinculin,
Hüttelmaier, Stefan +5 more
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Differential regulation of actin microfilaments by human MICAL proteins
Journal of Cell Science, 2012 The Drosophila melanogaster MICAL protein is essential for the neuronal growth cone machinery that functions through plexin- and semaphorin-mediated axonal signaling. Drosophila MICAL is also involved in regulating myofilament organization and synaptic structures, and serves as an actin disassembly factor downstream of plexin-mediated axonal repulsion.
Sai Srinivas Panapakkam, Giridharan +3 more
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Regulation of Apicomplexan Microfilament Dynamics by a Minimal Set of Actin‐Binding Proteins [PDF]
Traffic, 2006 Efficient and rapid host cell invasion is a prerequisite for an intracellular parasitic life style. Pathogens typically induce receptor‐mediated endocytosis and hijack the force‐transducing system of a host cell to gain access to a replication‐competent niche.
Herwig, Schüler, Kai, Matuschewski
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