Results 31 to 40 of about 16,157 (173)

Differential regulation of actin microfilaments by human MICAL proteins

Journal of Cell Science, 2012
The Drosophila melanogaster MICAL protein is essential for the neuronal growth cone machinery that functions through plexin- and semaphorin-mediated axonal signaling. Drosophila MICAL is also involved in regulating myofilament organization and synaptic structures, and serves as an actin disassembly factor downstream of plexin-mediated axonal repulsion.
Sai Srinivas Panapakkam, Giridharan, Jennifer L, Rohn, Naava, Naslavsky, Steve, Caplan   +3 more
openaire   +3 more sources

In vivo analysis of interactions between GFP-labeled microfilaments and plastid stromules

BMC Plant Biology, 2004
Background Plastid stromules are stroma-filled tubules that extend from the surface of plastids in higher plants and allow the exchange of protein molecules between plastids.
Kwok Ernest Y, Hanson Maureen R
doaj   +1 more source

RNA-binding protein conserved in both microtubule- and microfilament-based RNA localization [PDF]

Genes & Development, 1998
Vg1 mRNA translocation to the vegetal cortex ofXenopus oocytes requires intact microtubules, and a 3′ UTRcis-acting element (termed VLE), which also mediates sequence-specific binding of several proteins. One protein, the 69-kD Vg1 RBP, associates Vg1 RNA to microtubules in vitro.
L, Havin, A, Git, Z, Elisha, F, Oberman, K, Yaniv, S P, Schwartz, N, Standart, J K, Yisraeli   +7 more
openaire   +2 more sources

RhoA-GTPase Modulates Neurite Outgrowth by Regulating the Expression of Spastin and p60-Katanin

Cells, 2020
RhoA-GTPase (RhoA) is widely regarded as a key molecular switch to inhibit neurite outgrowth by rigidifying the actin cytoskeleton. However, during neurite outgrowth, whether and how microtubule dynamics are regulated by RhoA remains to be elucidated ...
Dandan Tan, Haowen Zhang, Junyao Deng, Jingmin Liu, Jinkun Wen, Lixia Li, Xianghai Wang, Mengjie Pan, Xiaofang Hu, Jiasong Guo   +9 more
doaj   +1 more source

Identification of key genes and validation of key gene aquaporin 1 on Wilms’ tumor metastasis [PDF]

PeerJ, 2023
Background Wilms’ tumor (WT) is one of the most common solid tumors in children with unsatisfactory prognosis, but few molecular prognostic markers have been discovered for it. Many genes are associated with the occurrence and prognosis of WT. This study
Hong Liu, Chen Jin, Xia Yang, Nan Xia, Chunzhi Guo, Qian Dong   +5 more
doaj   +2 more sources

Suppression of Tumorigenicity in Breast Cancer Cells by the Microfilament Protein Profilin 1 [PDF]

The Journal of Experimental Medicine, 2000
Differential display screening was used to reveal differential gene expression between the tumorigenic breast cancer cell line CAL51 and nontumorigenic microcell hybrids obtained after transfer of human chromosome 17 into CAL51. The human profilin 1 (PFN1) gene was found overexpressed in the microcell hybrid clones compared with the parental line ...
Janke, J., Schlueter, K., Jandrig, B., Theile, M., Koelble, K., Arnold, W., Grinstein, E., Schwartz, A., Estevez-Schwarz, L., Schlag, P.M., Jockusch, B.M., Scherneck, S.   +11 more
openaire   +3 more sources

Gas2, a growth arrest-specific protein, is a component of the microfilament network system [PDF]

The Journal of cell biology, 1992
In this report we analyze the protein product of a growth arrest-specific gene, gas2, by means of an affinity-purified antibody raised against the protein produced in bacteria. The regulation of Gas2 biosynthesis reflects the pattern of mRNA expression (Schneider, C., R. King, and L. Philipson. 1988. Cell.
BRANCOLINI, Claudio, BOTTEGA S, SCHNEIDER C.   +2 more
openaire   +3 more sources

Integration of Cardiac Actin Mutants Causing Hypertrophic (p.A295S) and Dilated Cardiomyopathy (p.R312H and p.E361G) into Cellular Structures

Antioxidants, 2021
The human mutant cardiac α-actins p.A295S or p.R312H and p.E361G, correlated with hypertrophic or dilated cardiomyopathy, respectively, were expressed by the baculovirus/Sf21 insect cell system and purified to homogeneity.
Constanze Erdmann, Roua Hassoun, Sebastian Schmitt, Carlos Kikuti, Anne Houdusse, Antonina J. Mazur, Andreas Mügge, Nazha Hamdani, Matthias Geyer, Kornelia Jaquet, Hans Georg Mannherz   +10 more
doaj   +1 more source

Trisoxazole Macrolides Potentiate the Microtubule Assembly and Antimitotic Activities of Taxanes

Angewandte Chemie, EarlyView.
Photoaffinity experiments identified tubulin as a new target of mycalolides. Though weakly cytotoxic, the trisoxazole macrolactone moiety enhanced paclitaxel's microtubule assembly and antimitotic effects. Molecular modeling studies suggested that MyC stabilizes α/β‐tubulin heterodimer interactions.
Shohei Ebihara, Rio Takaiso, Shota Kawaguchi, Atsunori Oshima, Masaki Kita   +4 more
wiley   +2 more sources

Synthesis of proto-oncogene proteins and cyclins depends on intact microfilaments

European Journal of Cell Biology, 1998
It is well established that microfilament disintegration by cytochalasin D (CD) as well as latrunculin (LAT)-A and LAT-B causes an inhibition of S phase entry of various nontransformed cell lines. Our experiments extended these observations to human embryonal diploid fibroblasts (Wi-38). To investigate the question whether this stop of DNA synthesis is
M, Fasshauer, M, Iwig, D, Glaesser
openaire   +2 more sources