Results 91 to 100 of about 388,044 (340)

Infrared Neural Stimulation Elicits Distinct Molecular Pathways in Astrocytes Based on Laser Pulse Parameters

Advanced Biology, EarlyView.
Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams, Ana I Borrachero‐Conejo, Pratheepa Kumari Rasiah, Emanuela Saracino, Roberto Zamboni, Eric Duco Jansen, Valentina Benfenati, Anita Mahadevan‐Jansen   +7 more
wiley   +1 more source

Microglia Polarization with M1/M2 Phenotype Changes in rd1 Mouse Model of Retinal Degeneration

Frontiers in Neuroanatomy, 2017
Microglia activation is recognized as the hallmark of neuroinflammation. However, the activation profile and phenotype changes of microglia during the process of retinal degeneration are poorly understood.
Tian Zhou, Zijing Huang, Xiaowei Sun, Xiaowei Zhu, Lingli Zhou, Mei Li, Bing Cheng, Xialin Liu, Chang He   +8 more
doaj   +1 more source

Negative feedback control of neuronal activity by microglia

Nature, 2020
Microglia, the brain’s resident macrophages, help to regulate brain function by removing dying neurons, pruning non-functional synapses, and producing ligands that support neuronal survival 1 .
Ana Badimon, Hayley J Strasburger, Pinar Ayata, Xinhong Chen, Aditya Nair, Ako Ikegami, Philip Hwang, Andrew T. Chan, Steven M. Graves, Joseph O. Uweru, Carola Ledderose, M. Kutlu, Michael A. Wheeler, A. Kahan, Masago Ishikawa, Ying-Chih Wang, Y. Loh, Jean X. Jiang, D. Surmeier, S. Robson, W. Junger, R. Sebra, E. Calipari, P. Kenny, Ukpong B. Eyo, M. Colonna, F. Quintana, H. Wake, V. Gradinaru, A. Schaefer   +29 more
semanticscholar   +1 more source

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

A Custom Panel for Profiling Microglia Gene Expression

Cells
Despite being immune cells of the central nervous system (CNS), microglia contribute to CNS development, maturation, and homeostasis, and microglia dysfunction has been implicated in several neurological disorders.
Phani Sankar Potru, Natascha Vidovic, Susanne Wiemann, Tamara Russ, Marcel Trautmann, Björn Spittau   +5 more
doaj   +1 more source

Bridelia ferruginea Produces Anti-neuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling [PDF]

, 2012
Bridelia ferruginea is commonly used in traditional African medicine (TAM) for treating various inflammatory conditions. Extracts from the plant have been shown to exhibit anti-inflammatory property in a number of in vivo models.
Aderogba, Mutallib A., Fiebich, B.L., Okorji, U. P., Olajide, Olumayokun A.   +3 more
core   +2 more sources

Microglia in Alzheimer’s disease

Journal of Cell Biology, 2018
Proliferation and activation of microglia in the brain, concentrated around amyloid plaques, is a prominent feature of Alzheimer’s disease (AD). Human genetics data point to a key role for microglia in the pathogenesis of AD.
David V. Hansen, Jesse E. Hanson, Morgan Sheng   +2 more
semanticscholar   +1 more source

Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease

Nature Communications, 2020
The extent of microglial heterogeneity in humans remains a central yet poorly explored question in light of the development of therapies targeting this cell type.
M. Olah, V. Menon, Naomi Habib, M. Taga, Yiyi Ma, Christina Yung, M. Cimpean, Anthony Khairallah, G. Coronas-Samano, R. Sankowski, Dominic Grün, Alexandra Kroshilina, Danielle Dionne, R. Sarkis, G. Cosgrove, Jeffrey J. Helgager, J. Golden, P. Pennell, M. Prinz, J. Vonsattel, A. Teich, J. Schneider, D. Bennett, A. Regev, W. Elyaman, E. Bradshaw, P. D. De Jager   +26 more
semanticscholar   +1 more source

Functional Hydrogel for Modulating Lipid Droplets and Neuroinflammation in Head Injury

Advanced Functional Materials, EarlyView.
After TBI, elevated cholesterol levels in activated microglia lead to the accumulation of cholesterol esters in lipid droplets, exacerbating neuroinflammation. A β‐cyclodextrin‐conjugated GelMA (βCD‐GelMA) hydrogel is developed to promotes cholesterol efflux and reduces LDL influx, thereby alleviating intracellular cholesterol and lipid droplet buildup.
Feixiang Chen, Yvonne Shen, Yutong Shao, Tenghuan Ge, Haowen Qiao, Shangzhou Xia, Yafei Qu, Yuanpu Chiu, Ying Qin, Zhen Zhao   +9 more
wiley   +1 more source

Differences in microglia morphological profiles reflect divergent emotional temperaments: insights from a selective breeding model

Translational Psychiatry, 2022
Microglia play critical roles in healthy brain development and function, as well as the neuropathology underlying a range of brain diseases. Despite evidence for a role of microglia in affective regulation and mood disorders, little is known regarding ...
Pamela M. Maras, Elaine K. Hebda-Bauer, Megan H. Hagenauer, Kathryn L. Hilde, Peter Blandino, Stanley J. Watson, Huda Akil   +6 more
doaj   +1 more source