Results 101 to 110 of about 334,601 (325)

Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease. [PDF]

, 2019
ObjectiveMicroglia play a pivotal role in the initiation and progression of Alzheimer's disease (AD). We here tested the therapeutic hypothesis that the Ca2+-activated potassium channel KCa3.1 constitutes a potential target for treating AD by reducing ...
Bushong, Trevor, Chavez, Monique, Jin, Lee-Way, Lucente, Jacopo Di, Maezawa, Izumi, Nguyen, Hai M, Singh, Latika, Singh, Vikrant, Wulff, Heike   +8 more
core   +2 more sources

Mitochondrial Transplantation via Magnetically Responsive Artificial Cells Promotes Intracerebral Hemorrhage Recovery by Supporting Microglia Immunological Homeostasis

Advanced Materials, Volume 37, Issue 13, April 2, 2025.
A type of magnetically responsive artificial cells (ACs) has been developed, demonstrating the loading of mitochondria and self‐enclosure processes to ensure the protection of mitochondrial transport via the bloodstream. The treatment with ACs effectively transplanted mitochondria around the lesion, thereby improving neurological recovery by supporting
Mi Zhou, Jinhui Zang, Yuxuan Qian, Qiang Zhang, Yifan Wang, Tingting Yao, Hongyu Yan, Kai Zhang, Xiaojun Cai, Lixian Jiang, Yuanyi Zheng   +10 more
wiley   +1 more source

Thermally Drawn Multifunctional All‐Hydrogel Fibers for Anti‐Fibrotic and Multimodal Neural Interfaces

Advanced Materials, EarlyView.
Hydrogels demonstrate material properties that mimic the mechanical and chemical environments of biological tissues. Yet, they face challenges during their integration into 3D interfaces. By identifying a class of thermoplastic hydrogels, a strategy is developed to pattern hydrogels in thermally drawn fibers.
Changhoon Sung, Kum Seok Nam, Yeji Kim, Honey Kang, Kanghyeon Kim, Chanwoong Yoon, Somin Lee, Ain Chung, Jiheong Kang, Young‐Gyun Park, Alan Jung Park, Haider Butt, Hyunwoo Yuk, Seongjun Park   +13 more
wiley   +1 more source

Pathogenesis and therapeutic applications of microglia receptors in Alzheimer’s disease

Frontiers in Immunology
Microglia, the resident immune cells of the central nervous system, continuously monitor the brain’s microenvironment through their array of specific receptors.
Jiao Fu, Jiao Fu, RuoXuan Wang, RuoXuan Wang, JiHui He, JiHui He, XiaoJing Liu, XiaoJing Liu, XinXin Wang, XinXin Wang, JuMing Yao, JuMing Yao, Ye Liu, ChongZhao Ran, QingSong Ye, Yan He, Yan He, Yan He   +17 more
doaj   +1 more source

Adaptive Müller cell responses to microglial activation mediate neuroprotection and coordinate inflammation in the retina

Journal of Neuroinflammation, 2011
Purpose Microglia and Müller cells are prominent participants in retinal responses to injury and disease that shape eventual tissue adaptation or damage.
Wang Minhua, Ma Wenxin, Zhao Lian, Fariss Robert N, Wong Wai T   +4 more
doaj   +1 more source

Zika virus infection reprograms global transcription of host cells to allow sustained infection. [PDF]

, 2017
Zika virus (ZIKV) is an emerging virus causally linked to neurological disorders, including congenital microcephaly and Guillain-Barré syndrome. There are currently no targeted therapies for ZIKV infection.
Bansal, Vikas, Dang, Jason, Lichinchi, Gianluigi, Qin, Yue, Rana, Tariq M, Tiwari, Shashi Kant   +5 more
core   +2 more sources

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

scRNA-Seq reveals age-dependent microglial evolution as a determinant of immune response following spinal cord injury

Brain Research Bulletin
Spinal cord injury (SCI) is a debilitating condition of the central nervous system (CNS) that leads to severe impairments in sensory and motor functions.
Lufei Shao, Yueliang Chang, Jinfang Liu, Leilei Lin, Long Chang, Jialin Zhang, Zhibin Lan, Honglai Zhang, Xiaolei Chen   +8 more
doaj   +1 more source

Piezoelectric Stimulation of Neural Cells: Exploring the Synergistic Potential of Hybrid Scaffolds for Enhanced Regeneration

Advanced Materials Interfaces, EarlyView.
Hybrid piezoelectric scaffolds offer a promising route for Central Nervous System regeneration by combining structural and electrical cues to support neural stem cell growth. This review highlights their potential to overcome current challenges in neural tissue engineering by exploring porous hybrid materials, their biological interactions, and ...
Heather F. Titterton, Chris R. Bowen, Hamideh Khanbareh   +2 more
wiley   +1 more source

Autophagy in Microglia and Alzheimer's disease [PDF]

, 2019
Alzheimer’s disease (AD) is the most common neurodegenerative disease, characterized by amyloid-beta plaques, neurofibrillary tangles and neuroinflammation. Autophagy has been associated with several neurodegenerative diseases.
Houtman, Judith
core   +1 more source