Results 101 to 110 of about 242,823 (354)
Advanced Therapeutics, EarlyView.Emerging microphysiological systems reproduce the spatial, biochemical, and cellular complexity of the tumor microenvironment, surpassing 2D cultures and murine models. By integrating patient‐derived tumors, perfusable vasculature, and immune trafficking, these organ‐on‐chip platforms reveal mechanisms of immune evasion, predict therapeutic responses ...
Fabiana Moresi +5 more
wiley +1 more source
Microglia cannibalism and efferocytosis leads to shorter lifespans of developmental microglia.
PLoS BiologyThe overproduction of cells and subsequent production of debris is a universal principle of neurodevelopment. Here, we show an additional feature of the developing nervous system that causes neural debris-promoted by the sacrificial nature of embryonic ...
Hannah Gordon +2 more
doaj +1 more source
A Custom Panel for Profiling Microglia Gene Expression
CellsDespite being immune cells of the central nervous system (CNS), microglia contribute to CNS development, maturation, and homeostasis, and microglia dysfunction has been implicated in several neurological disorders.
Phani Sankar Potru +5 more
doaj +1 more source
bioRxiv, 2019 Microglia become progressively activated and seemingly dysfunctional with age, and genetic studies have linked these cells to the pathogenesis of a growing number of neurodegenerative diseases.
J. Marschallinger +17 more
semanticscholar +1 more source
Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy
Advanced Therapeutics, EarlyView.This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar +7 more
wiley +1 more source
Dual microglia effects on blood brain barrier permeability induced by systemic inflammation
Nature Communications, 2019 Microglia survey brain parenchyma, responding to injury and infections. Microglia also respond to systemic disease, but the role of blood–brain barrier (BBB) integrity in this process remains unclear.
Koichiro Haruwaka +12 more
semanticscholar +1 more source
Progress in Histochemistry and Cytochemistry, 1996 Progress in Histochemistry and Cytochemistry 31 (1996) XII,1-XIV,89. doi:10.1016/S0079-6336(96)80004-0 ; Received by publisher: 0000-01-01 ; Harvest Date: 2016-01-04 12:21:02 ; DOI:10.1016/S0079-6336(96)80004-0 ; Page Range: XII,1-XIV ...
Department of Neuroscience, University of Florida Brain Institute, Grainville, FL-32610 (USA) ( host institution ) +2 more
openaire +3 more sources
Loss of NR2F6 Protects from Salmonella Typhimurium Infection
Advanced Science, EarlyView.Loss of nuclear receptor NR2F6 reduces tissue‐resident macrophage populations. Nr2f6‐deficient mice are protected from weight loss and bacterial load during infection with Salmonella Typhimurium. Pro‐inflammatory cytokines and iron levels are altered in infected Nr2f6‐deficient mice.
Johannes Woelk +8 more
wiley +1 more source
Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury
Nature Communications, 2019 The role of microglia in spinal cord injury (SCI) remains poorly understood and is often confused with the response of macrophages. Here, we use specific transgenic mouse lines and depleting agents to understand the response of microglia after SCI.
V. Bellver-Landete +10 more
semanticscholar +1 more source