Results 111 to 120 of about 334,601 (325)
Transcriptional and translational differences of microglia from male and female brains [PDF]
, 2019 Sex differences in brain structure and function are of substantial scientific interest because of sex-related susceptibility to psychiatric and neurological disorders. Neuroinflammation is a common denominator of many of these diseases and thus microglia
Güneykaya, Dilansu
core +1 more source
Physalis alkekengi L. var. francheti alleviates neuronal cell death caused by activated microglia in vitro [PDF]
, 2021 Byoung Hee Park +10 more
openalex +1 more source
Advanced Materials Technologies, EarlyView.This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang +4 more
wiley +1 more source
Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types. [PDF]
, 2017 Many subtypes of cortical interneurons (CINs) are found in adult mouse cortices, but the mechanism generating their diversity remains elusive. We performed single-cell RNA sequencing on the mouse embryonic medial ganglionic eminence (MGE), the major ...
Chen, Ying-Jiun J +7 more
core +1 more source
Advanced Materials Technologies, EarlyView.Modeling the blood–brain tumor barrier is challenging due to complex interactions between brain microvasculature and glioma cells. We present two‐photon polymerized 3D micro‐porous capillary‐like structures that support endothelial alignment, cytoskeletal organization, and pericyte‐endothelial‐glioma tri‐cultures.
Nastaran Barin +9 more
wiley +1 more source
Journal of Neuroinflammation, 2018 Background Microglia—the resident immune cells of the brain—are activated after brain lesions, e.g., cerebral ischemia, and polarize towards a classic “M1” pro-inflammatory or an alternative “M2” anti-inflammatory phenotype following characteristic ...
Sabine Ulrike Vay +10 more
doaj +1 more source
Advanced Science, EarlyView.Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann +26 more
wiley +1 more source
Advanced Science, EarlyView.This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang +9 more
wiley +1 more source
Allogenic microglia replacement: A novel therapeutic strategy for neurological disorders
Fundamental ResearchMicroglia are resident immune cells in the central nervous system (CNS) that play vital roles in CNS development, homeostasis and disease pathogenesis.
Yanxia Rao, Bo Peng
doaj +1 more source
The role of microglia and their CX3CR1 signaling in adult neurogenesis in the olfactory bulb
eLife, 2017 Microglia play important roles in perinatal neuro- and synapto-genesis. To test the role of microglia in these processes during adulthood, we examined the effects of microglia depletion, via treatment of mice with the CSF-1 receptor antagonist PLX5622 ...
Ronen Reshef +6 more
doaj +1 more source