Results 111 to 120 of about 116,651 (165)
Animal Models and Experimental Medicine, EarlyView.The present study investigates the role of the NLRP3 inflammasome in the chronicity of ocular inflammation in uveitis using the experimental autoimmune uveitis (EAU) model. Whole eyes collected from EAU mice, 12 weeks post induction, were sectioned and subjected to immunohistochemistry. The confocal images from these sections were then assessed for the
Avik Shome +3 more
wiley +1 more source
Distinct Alterations of Inflammatory Biomarkers in Cluster Headache: A Case Control Study
Annals of Neurology, EarlyView.Objective Investigate the immune system's role in cluster headache by analyzing cytokines in people with cluster headache and headache‐free controls, and explore if certain cytokines could predict a specific phenotype. Methods We measured 45 cytokines in adult participants from the Danish Cluster Headache Biobank in a prospective case–control setup ...
Nunu Laura Timotheussen Lund +6 more
wiley +1 more source
Annals of Neurology, EarlyView.Objectives Rapid advances in transcriptomics have driven efforts to identify deregulated pathways in multiple sclerosis (MS) tissues, though many detected differentially expressed genes are likely false positives, with only a small fraction reflecting actual pathological events. Robust, integrative methods are essential for accurately understanding the
Gianmarco Abbadessa +11 more
wiley +1 more source
The Anatomical Record, EarlyView.Abstract Hibernation induces significant molecular and cellular adaptations in the retina to maintain function under reduced metabolic conditions. This study aimed to investigate the expression of neuronal, synaptic, and glial markers in the retina of Spermophilus xanthoprymnus during pre‐hibernation and hibernation periods using immunohistochemical ...
Mehmet Özbek +5 more
wiley +1 more source
Animal Research and One Health, EarlyView.The paper is divided into three main sections: a review of the development of spatial transcriptomics technology, its applications in livestock and poultry research, and its future prospects. This article provides an overview of the current state of spatial transcriptomics in animal research, exploring its integration with multiomics technologies as ...
Mingyu Wang +5 more
wiley +1 more source
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Senkyunolide I (Sen I) has a protective effect on the blood–brain barrier (BBB) in rats with sepsis‐associated encephalopathy (SAE). This study investigated whether Sen I regulates Nrf2 to ameliorate sepsis‐induced brain dysfunction (SIBD). Sixty rats were randomly assigned into Sham group, SAE group (Model group), SAE + Sen I group (72 mg/kg,
Haohao Cao, Tao Liu, Meixia Xu
wiley +1 more source
Neural electrodes for brain‐computer interface system: From rigid to soft
BMEMat, EarlyView.Here, we review the development trends of neural electrodes in BCI. This paper highlights the critical role of electrodes in BCI systems, analyzes the limitations of rigid electrodes, and introduces various flexible electrodes. Furthermore, we discuss application scenarios and prospects of BCI electrode technology, aiming to provide valuable references
Dan Yang +7 more
wiley +1 more source
Deciphering the skeletal interoceptive circuitry to control bone homeostasis
BMEMat, EarlyView.This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu +7 more
wiley +1 more source
BMEMat, EarlyView.The study reveals that microglial activation significantly contributes to neuroinflammation following cerebral ischemia‐reperfusion injury. It demonstrates that utilizing GelMA hydrogel for three‐dimensional culture of bone marrow‐derived mesenchymal stem cells (BMSCs) enhances the efficacy of BMSC‐derived exosomes in regulating microglial polarization
Yuming Li +13 more
wiley +1 more source
Cancer Communications, EarlyView.Abstract Background Glioblastoma (GBM) is largely refractory to antibodies against programmed cell death 1 (anti‐PD‐1) therapy. Fully understanding the cellular heterogeneity and immune adaptations in response to anti‐PD‐1 therapy is necessary to design more effective immunotherapies for GBM.
Rongrong Zhao +11 more
wiley +1 more source