Results 111 to 120 of about 174,983 (281)
RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development
Advanced Science, EarlyView.The study investigates the role of RACK7 in brain development using a conditional knockout mouse model. RACK7 deficiency results in developmental defects and abnormal astrocyte development by disrupting H3K27me3 chromatin binding. The underlying mechanism involves RACK7 interacting with the PRC2 complex to regulate the genomic localization of SUZ12 and
Fangfang Jiao +9 more
wiley +1 more source
Brain and Behavior, Volume 12, Issue 12, December 2022., 2022 Abstract Aim The aim of this study was to investigate the therapeutic roles of Tetrandrine (TET) on traumatic brain injury (TBI) and the underlying mechanism. Method Traumatic injury model of hippocampal neurons and TBI mouse model were established to evaluate the therapeutic effects.
Huan Liu +6 more
wiley +1 more source
Advanced Science, EarlyView.S‐ketamine binds directly to SIRT2, facilitating its interaction with NF‐κB p65. This interaction reduces the acetylation of NF‐κB p65 and inhibits its activation, thereby exerting anti‐inflammatory and antidepressant effects. Created by BioRender.
Cong Lin +7 more
wiley +1 more source
Brain and Behavior, Volume 12, Issue 12, December 2022., 2022 Abstract Aim The aims of this pilot study were to investigate the levels of biomarkers of microglial/macrophage activation—YKL‐40, sCD163, and sCD14—in patients with neuromyelitis optica spectrum disorder (NMOSD) and determine the possible associations between these biomarkers and Expanded Disability Status Scale (EDSS) scores.
Jinghong Li +3 more
wiley +1 more source
Using GANs for De Novo Protein Design Targeting Microglial IL-3R$α$ to Inhibit Alzheimer's Progression [PDF]
arXivIL-3 is a hemopoietic growth factor that usually targets blood cell precursors; IL-3R is a cytokine receptor that binds to IL-3. However, IL-3 takes on a different role in the context of glial cells in the nervous system, where studies show that the protein IL-3 protects against Alzheimer's disease by activating microglia at their IL-3R receptors ...
arxiv
Advanced Science, EarlyView.Annexin A3 (ANXA3) plays an endogenous protective role in endothelial dysfunction in sepsis by stabilizing the actin cytoskeleton, modulating cell permeability, and inhibiting pATF2/CD62E inflammatory signaling. Abstract Increased endothelial permeability and a dysregulated inflammatory response play key roles in organ damage in sepsis.
Manyu Xing +4 more
wiley +1 more source
Gamma oscillations and application of 40‐Hz audiovisual stimulation to improve brain function
Brain and Behavior, Volume 12, Issue 12, December 2022., 2022 Abstract Background Audiovisual stimulation, such as auditory stimulation, light stimulation, and audiovisual combined stimulation, as a non‐invasive stimulation, which can induce gamma oscillation, has received increased attention in recent years, and it has been preliminarily applied in the clinical rehabilitation of brain dysfunctions, such as ...
Xixi Chen +6 more
wiley +1 more source
Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat [PDF]
, 1995 D. Scott Stephenson +5 more
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Advanced Science, EarlyView.This work proposes a new mechanism for the regulation of LDs metabolism by ANXA7/PPARγ. ANXA7 can interact with PPARγ to promote its stability. ANXA7 activation promotes PPARγ nuclear translocation, thus promoting LDs formation and interaction with mitochondria by promoting PLIN5 expression.
Lu Chen +6 more
wiley +1 more source
Microglia-Derived Nerve Growth Factor Causes Cell Death in the Developing Retina [PDF]
, 1998 José M. Frade, Yves‐Alain Barde
openalex +1 more source