Results 11 to 20 of about 266,602 (329)

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes [PDF]

Translational Neurodegeneration, 2020
Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Microglia and astrocytes are key regulators of inflammatory responses in the central nervous system. The
Hyuk Sung Kwon, Seong‐Ho Koh
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Microglia in neurodegeneration

Nature Neuroscience, 2018
The neuroimmune system is involved in development, normal functioning, aging, and injury of the central nervous system. Microglia, first described a century ago, are the main neuroimmune cells and have three essential functions: a sentinel function involved in constant sensing of changes in their environment, a housekeeping function that promotes ...
Suzanne Hickman, Saef Izzy, Pritha Sen, Liza Morsett, Joseph El Khoury   +4 more
openaire   +4 more sources

Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets

Signal Transduction and Targeted Therapy, 2023
Microglia activation is observed in various neurodegenerative diseases. Recent advances in single-cell technologies have revealed that these reactive microglia were with high spatial and temporal heterogeneity.
Chao Gao, Jingwen Jiang, Yuyan Tan, Shengdi Chen   +3 more
semanticscholar   +1 more source

Microglia Mediated Neuroinflammation in Parkinson’s Disease

Cells, 2023
Parkinson’s Disease (PD) is the second most common neurodegenerative disorder seen, especially in the elderly. Tremor, shaking, movement problems, and difficulty with balance and coordination are among the hallmarks, and dopaminergic neuronal loss in ...
Sevim Isik, Bercem Yeman Kiyak, Rumeysa Akbayir, Rama Seyhali, Tahire Arpacı   +4 more
semanticscholar   +1 more source

Microglia Polarization From M1 to M2 in Neurodegenerative Diseases

Frontiers in Aging Neuroscience, 2022
Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).
Shenrui Guo, Hui Wang, Yafu Yin
semanticscholar   +1 more source

Microglia regulate central nervous system myelin growth and integrity

Nature, 2022
Resident microglia in the central nervous system are identified as the specific macrophage population that regulates myelin growth and integrity. Myelin is required for the function of neuronal axons in the central nervous system, but the mechanisms that
N. McNamara, David A. D. Munro, Nadine Bestard-Cuche, Akiko Uyeda, Jeroen F. J. Bogie, A. Hoffmann, Rebecca K. Holloway, Irene Molina-Gonzalez, Katharine E. Askew, Stephen Mitchell, W. Mungall, Michael Dodds, Carsten Dittmayer, J. Moss, Jamie L. Rose, S. Szymkowiak, Lukas Amann, B. McColl, M. Prinz, T. Spires-Jones, W. Stenzel, K. Horsburgh, Jerome J. A. Hendriks, Clare Pridans, R. Muramatsu, Anna C. Williams, Josef Priller, V. Miron   +27 more
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Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression

Journal of Neuroinflammation, 2022
Major depressive disorder is a highly debilitating psychiatric disorder involving the dysfunction of different cell types in the brain. Microglia are the predominant resident immune cells in the brain and exhibit a critical role in depression.
Haixia Wang, Yi He, Zuoli Sun, Si-yu Ren, Mingxia Liu, G. Wang, Jian Yang   +6 more
semanticscholar   +1 more source

Comparing the Characteristics of Microglia Preparations Generated Using Different Human iPSC-Based Differentiation Methods to Model Neurodegenerative Diseases

ASN Neuro, 2022
As the resident immune cells of the healthy nervous system, homeostatic microglia can rapidly become activated in response to injury/disease. Dysregulated microglia activation is a hallmark of nervous system disorders including neurodegenerative diseases
Ye Man Tang, Nisha S. Pulimood, Stefano Stifani   +2 more
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Expression and role of triggering receptor expressed on myeloid cells 2 in high glucose-treated microglia [PDF]

Jichu yixue yu linchuang
Objective To explore the expression of triggering receptor expressed on myeloid cells 2 (TREM2) in high-glucose microglia and to investigate the role of TREM2 in the proliferation, migration and phagocytosis of high-glucose microglia.
WANG Zhaohui, LIU Xiao, ZHOU Yue, WEI Xinyi, WANG Yue, LI Junfa, ZHAO Li
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The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function

Journal of Neuroinflammation, 2020
Background Microglia are essential to maintain cell homeostasis in the healthy brain and are activated after brain injury. Upon activation, microglia polarize towards different phenotypes.
Sabine Ulrike Vay, Lea Jessica Flitsch, Monika Rabenstein, Helena Monière, Igor Jakovcevski, Pavle Andjus, Dunja Bijelic, Stefan Blaschke, Helene Luise Walter, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger   +11 more
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