Results 11 to 20 of about 379,641 (387)

Physiology of microglia. [PDF]

Physiological Reviews, 2011
Microglial cells are the resident macrophages in the central nervous system. These cells of mesodermal/mesenchymal origin migrate into all regions of the central nervous system, disseminate through the brain parenchyma, and acquire a specific ramified morphological phenotype termed “resting microglia.” Recent studies indicate that even in the normal ...
H. Kettenmann, U. Hanisch, M. Noda, A. Verkhratsky   +3 more
semanticscholar   +4 more sources

Microglia-derived microvesicles affect microglia phenotype in glioma [PDF]

Frontiers in Cellular Neuroscience, 2019
Extracellular-released vesicles (EVs), such as microvesicles (MV) and exosomes (Exo) provide a new type of inter-cellular communication, directly transferring a ready to use box of information, consisting of proteins, lipids and nucleic acids.
Alfonso Grimaldi, Angelo Sarra, Barbara Ruzicka, Carmela Serpe, Cristina Limatola, Cristina Limatola, Francesca Guerrieri, Giancarlo Ruocco, Giuseppe Familiari, Giuseppe Rubens Pascucci, Giuseppina Chece, Michela Relucenti, Myriam Catalano, Myriam Catalano, Valentina Nigro   +14 more
core   +10 more sources

Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression

Journal of Neuroinflammation, 2022
Major depressive disorder is a highly debilitating psychiatric disorder involving the dysfunction of different cell types in the brain. Microglia are the predominant resident immune cells in the brain and exhibit a critical role in depression.
Haixia Wang, Yi He, Zuoli Sun, Si-yu Ren, Mingxia Liu, G. Wang, Jian Yang   +6 more
semanticscholar   +4 more sources

Microglia in neurodegeneration

Nature Neuroscience, 2018
The neuroimmune system is involved in development, normal functioning, aging, and injury of the central nervous system. Microglia, first described a century ago, are the main neuroimmune cells and have three essential functions: a sentinel function involved in constant sensing of changes in their environment, a housekeeping function that promotes ...
S. Hickman, Saef Izzy, Pritha Sen, Liza M. Morsett, J. El Khoury   +4 more
semanticscholar   +4 more sources

Melatonin and Microglia [PDF]

International Journal of Molecular Sciences, 2021
Melatonin interacts in multiple ways with microglia, both directly and, via routes of crosstalk with astrocytes and neurons, indirectly. These effects of melatonin are of relevance in terms of antioxidative protection, not only concerning free-radical detoxification, but also in prevention of processes that cause, promote, or propagate oxidative stress
Hardeland, Rüdiger, Hardeland, Rüdiger; Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Göttingen, 37073 Göttingen, Germany, rhardel@gwdg.de   +1 more
openaire   +3 more sources

Microglia and Microglia-Like Cells: Similar but Different [PDF]

Frontiers in Cellular Neuroscience, 2022
Microglia are the tissue-resident macrophages of the central nervous parenchyma. In mammals, microglia are thought to originate from yolk sac precursors and posteriorly maintained through the entire life of the organism. However, the contribution of microglial cells from other sources should also be considered.
Cuadros Ojeda, Miguel Ángel, Sepúlveda Justo, María Del Rosario, Martín Oliva, Francisco David, Marín Teva, José Luis, Neubrand, Veronika Elisabeth   +4 more
openaire   +4 more sources

Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets

Signal Transduction and Targeted Therapy, 2023
Microglia activation is observed in various neurodegenerative diseases. Recent advances in single-cell technologies have revealed that these reactive microglia were with high spatial and temporal heterogeneity.
Chao Gao, Jingwen Jiang, Yuyan Tan, Shengdi Chen   +3 more
semanticscholar   +1 more source

Aging microglia

Cellular and Molecular Life Sciences, 2023
AbstractMicroglia are the tissue-resident macrophage population of the brain, specialized in supporting the CNS environment and protecting it from endogenous and exogenous insults. Nonetheless, their function declines with age, in ways that remain to be fully elucidated.
Ignazio Antignano, Yingxiao Liu, Nina Offermann, Melania Capasso   +3 more
openaire   +2 more sources

Death by microglia [PDF]

Journal of Experimental Medicine, 2019
The roles of microglia and ApoE in tauopathies, such as Alzheimer’s disease, remain elusive. In this issue, Shi et al. (https://doi.org/10.1084/jem.20190980) demonstrate that microglia-mediated innate immunity collaborates with ApoE to drive neurodegeneration and disease progression in a mouse model of tauopathy.
Shahrnaz Kemal, Robert Vassar
openaire   +3 more sources

Microglia Polarization From M1 to M2 in Neurodegenerative Diseases

Frontiers in Aging Neuroscience, 2022
Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).
Shenrui Guo, Hui Wang, Yafu Yin
semanticscholar   +1 more source