Results 11 to 20 of about 388,044 (340)
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
Signal Transduction and Targeted Therapy, 2023 Microglia activation is observed in various neurodegenerative diseases. Recent advances in single-cell technologies have revealed that these reactive microglia were with high spatial and temporal heterogeneity.
Chao Gao +3 more
semanticscholar +1 more source
Microglia Mediated Neuroinflammation in Parkinson’s Disease
Cells, 2023 Parkinson’s Disease (PD) is the second most common neurodegenerative disorder seen, especially in the elderly. Tremor, shaking, movement problems, and difficulty with balance and coordination are among the hallmarks, and dopaminergic neuronal loss in ...
Sevim Isik +4 more
semanticscholar +1 more source
Frontiers in Immunology, 2023 Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and oxidative stress play important roles in various complex mechanisms of IS.
Jinsong Zeng +8 more
semanticscholar +1 more source
Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
Translational Neurodegeneration, 2020 Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Microglia and astrocytes are key regulators of inflammatory responses in the central nervous system. The
H. S. Kwon, S. Koh
semanticscholar +1 more source
Inhibition of inflammatory microglia by dietary fiber and short-chain fatty acids
Scientific Reports, 2023 Microglia play a vital role maintaining brain homeostasis but can also cause persistent neuroinflammation. Short-chain fatty acids (SCFAs) produced by the intestinal microbiota have been suggested to regulate microglia inflammation indirectly by ...
M. Caetano-Silva +5 more
semanticscholar +1 more source
Microglia Polarization From M1 to M2 in Neurodegenerative Diseases
Frontiers in Aging Neuroscience, 2022 Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).
Shenrui Guo, Hui Wang, Yafu Yin
semanticscholar +1 more source
Microglia regulate central nervous system myelin growth and integrity
Nature, 2022 Resident microglia in the central nervous system are identified as the specific macrophage population that regulates myelin growth and integrity. Myelin is required for the function of neuronal axons in the central nervous system, but the mechanisms that
N. McNamara +27 more
semanticscholar +1 more source
Reformulating Pro-Oxidant Microglia in Neurodegeneration [PDF]
, 2019 In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent genome-wide transcriptomic analyses of microglial cells under different disease conditions have uncovered a new subpopulation named ...
Alonso Bellido, Isabel María +13 more
core +2 more sources
Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits. [PDF]
, 2018 Microglia are the main immune component in the brain that can regulate neuronal health and synapse function. Exposure to cosmic radiation can cause long-term cognitive impairments in rodent models thereby presenting potential obstacles for astronauts ...
Campbell-Beachler, Mary +10 more
core +2 more sources
Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression
Journal of Neuroinflammation, 2022 Major depressive disorder is a highly debilitating psychiatric disorder involving the dysfunction of different cell types in the brain. Microglia are the predominant resident immune cells in the brain and exhibit a critical role in depression.
Haixia Wang +6 more
semanticscholar +1 more source