Results 11 to 20 of about 311,522 (275)

Microglia-Derived Microvesicles Affect Microglia Phenotype in Glioma [PDF]

Frontiers in Cellular Neuroscience, 2019
Extracellular-released vesicles (EVs), such as microvesicles (MV) and exosomes (Exo) provide a new type of inter-cellular communication, directly transferring a ready to use box of information, consisting of proteins, lipids and nucleic acids. In the nervous system, EVs participate to neuron-glial cross-talk, a bidirectional communication important to ...
Alfonso Grimaldi, Carmela Serpe, Giuseppina Chece, Valentina Nigro, Angelo Sarra, Barbara Ruzicka, Michela Relucenti, Giuseppe Familiari, Giancarlo Ruocco, Giuseppe Rubens Pascucci, Francesca Guerrieri, Cristina Limatola, Cristina Limatola, Myriam Catalano, Myriam Catalano   +14 more
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The role of microglia in Alzheimer's disease and progress of treatment

Ibrain, 2022
Microglia are permanent immune cells of the central nervous system. Microglia play an important role in the pathological process of Alzheimer's disease (AD). They are mainly involved in the uptake and clearance of amyloid‐β (Aβ), as well as the formation
Yi‐Huan Guan, Ling‐Jing Zhang, Shi‐Ya Wang, Ya‐Dan Deng, Hong‐Su Zhou, Dong‐Qing Chen, Lan‐Chun Zhang   +6 more
doaj   +1 more source

Reformulating Pro-Oxidant Microglia in Neurodegeneration [PDF]

, 2019
In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent genome-wide transcriptomic analyses of microglial cells under different disease conditions have uncovered a new subpopulation named ...
Alonso Bellido, Isabel María, Burguillos García, Miguel Ángel, Cruz Hernández, Luis, Espinosa Oliva, Ana María, García Domínguez, Irene, García Revilla, Juan, Herrera Carmona, Antonio José, Martínez de Pablos, Rocío, Roca Ceballos, María Angustias, Rodríguez Gómez, José Antonio, Ruiz Laza, Rocío, Santiago Pavón, Martiniano, Sarmiento Soto, Manuel, Venero Recio, José Luis   +13 more
core   +2 more sources

Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits. [PDF]

, 2018
Microglia are the main immune component in the brain that can regulate neuronal health and synapse function. Exposure to cosmic radiation can cause long-term cognitive impairments in rodent models thereby presenting potential obstacles for astronauts ...
Campbell-Beachler, Mary, Chou, Austin, Feng, Xi, Grue, Katherine, Jones, Tamako, Krukowski, Karen, Nelson, Gregory, Paladini, Maria Serena, Riparip, Lara-Kirstie, Rosi, Susanna, Sacramento, Kristen   +10 more
core   +2 more sources

Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model [PDF]

, 2020
Alzheimer's disease, progressive supranuclear palsy and frontotemporal dementia are characterized by neuronal expression of aberrant tau protein, tau hyperphosphorylation (pTAU), tau aggregation and neurofibrillary tangle formation sequentially ...
Carmans, Sofie, de Vries, Helga E., Franssen, Marc, Kamermans, Alwin, Popovic, Marko, Roucourt, Bart, Schouten, Marijn, Sobrino, Tomás, van der Pol, Susanne M.A., van Olst, Lynn, Vandenbroucke, Roosmarijn, Verhaege, Daan, Wever, Dennis, Ytebrouck, Ellen   +13 more
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Expression and role of triggering receptor expressed on myeloid cells 2 in high glucose-treated microglia [PDF]

Jichu yixue yu linchuang
Objective To explore the expression of triggering receptor expressed on myeloid cells 2 (TREM2) in high-glucose microglia and to investigate the role of TREM2 in the proliferation, migration and phagocytosis of high-glucose microglia.
WANG Zhaohui, LIU Xiao, ZHOU Yue, WEI Xinyi, WANG Yue, LI Junfa, ZHAO Li
doaj   +1 more source

Microglia

Metabolic Brain Disease, 2004
Microglia--the macrophage equivalent of the CNS--safeguards and supports neuronal functions. Threats to the CNS homeostasis can trigger a rapid transformation of these cells from a normally "resting" into alerted and "activated" states. Microglia primarily serves the tissue defence and protection when participating in mechanisms of innate and adaptive ...
van Rossum, Denise, Hanisch, Uwe-Karsten
openaire   +3 more sources

Comparing the Characteristics of Microglia Preparations Generated Using Different Human iPSC-Based Differentiation Methods to Model Neurodegenerative Diseases

ASN Neuro, 2022
As the resident immune cells of the healthy nervous system, homeostatic microglia can rapidly become activated in response to injury/disease. Dysregulated microglia activation is a hallmark of nervous system disorders including neurodegenerative diseases
Ye Man Tang, Nisha S. Pulimood, Stefano Stifani   +2 more
doaj   +1 more source

Developmental Apoptosis Promotes a Disease-Related Gene Signature and Independence from CSF1R Signaling in Retinal Microglia

Cell Reports, 2019
Summary: Microglia have important remodeling functions in neurodevelopment, aging, and disease, with evidence for molecular diversity. However, the signaling pathways and environmental cues that drive diverse states of microglia are incompletely ...
Sarah R. Anderson, Jacqueline M. Roberts, Jianmin Zhang, Michael R. Steele, Cesar O. Romero, Alejandra Bosco, Monica L. Vetter   +6 more
doaj   +1 more source

CXCL16/CXCR6 axis drives microglia/macrophages phenotype in physiological conditions and plays a crucial role in glioma [PDF]

, 2018
Microglia are patrolling cells that sense changes in the brain microenvironment and respond acquiring distinct phenotypes that can be either beneficial or detrimental for brain homeostasis.
Antonangeli, Fabrizio, D'Alessandro, Giuseppina, Esposito, Vincenzo, Lepore, Francesca, Limatola, Cristina, Santoro, Antonio, Trettel, Flavia   +6 more
core   +1 more source