Results 191 to 200 of about 334,601 (325)

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

Microglia and Myeloid Cell Populations of the Developing Mouse Retina. [PDF]

Glia
Martineau S, Valdez-Lopez JC, Zarnick S, Kay JN.   +3 more
europepmc   +1 more source

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques [PDF]

, 2016
Cella, Marina, Cirrito, John R, Colonna, Marco, et al,, Gilfillan, Susan, Holtzman, David M, Mahan, Thomas E, Shi, Yang, Song, Wilbur, Ulland, Tyler K, Ulrich, Jason D, Wang, Yaming   +11 more
core   +2 more sources

Single‐Target Pairing System (StarPair) for Large‐Scale Interrogation of Cell–Cell Interactions

Advanced Science, EarlyView.
This work presents a single‐target pairing system, StarPair, enabling cell–cell interaction studies by target combination in droplets. StarPair offers superior pairing efficiencies over 95% and operation frequencies of 105 pairs per 9.5 h for two‐target pairing, allowing large‐scale interrogation of immune cell‐cancer cell interactions and precise ...
Tianjiao Mao, Lang Nan, Miao Xu, Kehao Zeng, Yuchao Wang, Ziyu Han, Ho Cheung Shum   +6 more
wiley   +1 more source

Basic Microglial Functions and How They Go Awry in Neurodegenerative Disease. [PDF]

Annu Rev Pathol
McKinney JE, Bennett ML, Bennett FC.
europepmc   +1 more source

Quinpirole ameliorates the dysfunction of microglia in human LRRK2-R1441G transgenic mice [PDF]

Yuanxin Chen, S. Cui, Huaixin Wang, Chenbo Zeng, Hui Zhang   +4 more
openalex   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Acute anti-Aβ antibody exposure induces microglial changes and significantly alters chemokine signaling. [PDF]

Alzheimers Dement (N Y)
Foley KE, Weekman EM, Wilcock DM.
europepmc   +1 more source

Table 2_Novel diagnostic biomarkers associated with macrophage-microglia in spinal cord injury.xlsx

Manyi Zheng (22221913), Yunduo Jiang (22221916), Fangyu Liu (92423), Yansong Wang (1955323)   +3 more
openalex   +1 more source

OPTRACE: Optical Imaging–Guided Transplantation and Tracking of Cells in the Mouse Brain

Advanced Science, EarlyView.
OPTRACE establishes an optical, two‐step platform for intracerebral cell therapy. Transparent glass pipettes enable real‐time, image‐guided delivery, while multiplex genetic labeling with two‐photon and bioluminescence readouts supports longitudinal single‐cell tracking and host–graft dynamics.
Jinghui Wang, Honglin Tan, Colleen Russell, Mikolaj Walczak, Dawei Gao, Guanda Qiao, Xiaoxuan Fan, Chengyan Chu, Miroslaw Janowski, Piotr Walczak, Yajie Liang   +10 more
wiley   +1 more source