Results 201 to 210 of about 388,044 (340)

Midkine‐Mediated Microglia Activation after Renal Injury Promotes Cognitive Impairment Following Ischemic Renal Injury

Advanced Science, EarlyView.
The mechanism of secondary cognitive impairment following AKI. When renal ischemic injury progresses to fibrosis, renal fibroblasts and damaged tubular cells secrete MDK, which circulates through the bloodstream, crosses the damaged BBB, and accumulates in the hippocampus tissue (an area crucial for learning and memory).
Li Lu, Bixiao Liu, Yu Yang, Tao Meng, Yuanyuan Chang, Yao Peng, Jia Guo, Zhuqing Wang, Hongqian Guo, Liuhua Zhou, Xiaozhi Zhao   +10 more
wiley   +1 more source

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.

Immunity, 2017
S. Krasemann, C. Madore, R. Cialic, Caroline Baufeld, Narghes Calcagno, Rachid El Fatimy, L. Beckers, E. O’Loughlin, Yang Xu, Zain Fanek, David J. Greco, Scott t. Smith, G. Tweet, Zachary Humulock, Tobias Zrzavy, Patricia Conde-Sanroman, Mar Gacias, Z. Weng, Hao Chen, Emily C. Tjon, F. Mazaheri, K. Hartmann, A. Madi, J. Ulrich, M. Glatzel, A. Worthmann, J. Heeren, B. Budnik, C. Lemere, T. Ikezu, F. Heppner, V. Litvak, D. Holtzman, H. Lassmann, H. Weiner, J. Ochando, C. Haass, O. Butovsky   +37 more
semanticscholar   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, EarlyView.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Retinal pigment epithelium cells alter the pro‐inflammatory response of retinal microglia to TLR‐3 stimulation [PDF]

, 2014
Alexa Klettner, Timothy Hamann, Karen Schlüter, Ralph Lucius, Johann Roider   +4 more
openalex   +1 more source

Microglia Function in the Central Nervous System During Health and Neurodegeneration.

Annual Review of Immunology, 2017
M. Colonna, O. Butovsky
semanticscholar   +1 more source

Exploration of Novel Biomarkers Through a Precision Medicine Approach Using Multi‐Omics and Brain Organoids in Patients With Atypical Depression and Psychotic Symptoms

Advanced Science, EarlyView.
This study examines major depressive disorder with atypical features and psychotic symptoms through a multi‐omics precision medicine approach. By integrating clinical assessments, WBC scRNA‐seq, plasma proteomics, and brain organoid models, it uncovers immune dysregulation, synaptic protein alterations, and stress‐sensitive neuronal changes.
Insook Ahn, Soyeon Chang, Jiyoung Lee, Seok‐Ho Choi, Jinju Han, Yangsik Kim   +5 more
wiley   +1 more source

Maternal inflammation induces immune activation of fetal microglia and leads to disrupted microglia immune responses, behavior, and learning performance in adulthood

, 2017
W. Schaafsma, Laura Bozal‐Basterra, Sabrina Jacobs, Nieske Brouwer, Peter Meerlo, Anne Schaafsma, Erik Boddeke, Bart J. L. Eggen   +7 more
openalex   +2 more sources

Host microbiota constantly control maturation and function of microglia in the CNS

Nature Neuroscience, 2015
Daniel Erny, Anna Lena Hrabě de Angelis, Diego Jaitin, Peter Wieghofer, O. Staszewski, Eyal David, Hadas Keren-Shaul, Tanel Mahlakõiv, Kristin Jakobshagen, T. Buch, V. Schwierzeck, O. Utermöhlen, Eunyoung Chun, W. Garrett, K. McCoy, A. Diefenbach, P. Staeheli, B. Stecher, I. Amit, M. Prinz   +19 more
semanticscholar   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats

, 2018
Peter M. Grace, Xiaohui Wang, Keith A. Strand, Michael V. Baratta, Yingning Zhang, Erika L. Galer, Hang Yin, Steven F. Maier, Linda R. Watkins   +8 more
openalex   +2 more sources