Results 231 to 240 of about 388,044 (340)

Hypothalamic Microglia as Dual Hubs Orchestrating Local and Systemic Homeostasis in the Periphery-Central-Periphery Axis. [PDF]

Cells
Liu Y, Jiang Q, Huang Y, Zhang X, Kang H, Yu C, Xia Y, Liu Y, Zhang H.   +8 more
europepmc   +1 more source

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

Neuron, 2012
D. Schafer, Emily K. Lehrman, Amanda G Kautzman, R. Koyama, Alan R. Mardinly, R. Yamasaki, R. Ransohoff, M. Greenberg, B. Barres, B. Stevens   +9 more
semanticscholar   +1 more source

Heat Stress Modulates WDR5‐Mediated H3K4me3 Modification to Induce Melanogenesis via Activating CX3CL1/CX3CR1 Axis

Advanced Science, EarlyView.
This study elucidates the mechanism by which heat stress regulates skin pigmentation: heat stress upregulates CX3CL1 through the MYC‐WDR5‐H3K4me3 axis, thereby activating the CX3CL1/CX3CR1‐JNK signaling pathway and ultimately promoting melanogenesis. These findings provide novel potential therapeutic targets for pigmentary skin disorders.
Yushan Zhang, Ling Jiang, Yibo Hu, Chuhan Fu, Jinhua Huang, Jing Chen, Qinghai Zeng   +6 more
wiley   +1 more source

Microglia's Phenotypic Heterogeneity in Pain Pathogenesis and Electroacupuncture Analgesia: Mechanisms and Therapeutic Potential. [PDF]

J Pain Res
Ji D, Lyu Z, Erasmus S, Wu Y, Li X, Chen X, Fang J, Du J, Fang J, Zhou J, Liang Y.   +10 more
europepmc   +1 more source

Caffeic acid phenethyl ester attenuates neuropathic pain by suppressing the p38/NF-κB signal pathway in microglia

, 2018
Hao Cheng, Yong Zhang, Weiping Lu, Xian-zhong Gao, Chenjie Xu, Hongguang Bao   +5 more
openalex   +2 more sources

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

"Rewiring brain immunity: targeting microglial metabolism for neuroprotection in neurodegenerative disorders". [PDF]

Metab Brain Dis
Shokr MM.
europepmc   +1 more source

Hypothyroidism Promotes Microglia M1 Polarization by Inhibiting BDNF-Promoted PI3K-Akt Signaling Pathway

Yuan Zhan, Lang Lang, Fen Wang, Xian Wu, Haiwang Zhang, Yi Dong, Hao Yang, De-Fa Zhu   +7 more
openalex   +1 more source

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

Advanced Science, EarlyView.
Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie, Qiuyang Zheng, Jiaming Lv, Qian Zhang, Zhiwei Cui, Shuai Huang, Wei Yu, Binyang Chen, Wanling Que, Shanpan Fu, Yuemei Xi, Jiayu Chen, Xueling Ye, Shuyi Chen, Hairong Zhao, Tetsuya Yamamoto, Hidenori Koyama, Xin Wang, Jidong Cheng   +18 more
wiley   +1 more source

RIG-I drives protective type I interferon production by glial cells in response to <i>Neisseria meningitidis</i> and <i>Streptococcus pneumoniae</i> challenge. [PDF]

Front Immunol
Majithia KJ, Johnson MB.
europepmc   +1 more source