Results 231 to 240 of about 174,983 (281)

Nucleus accumbens shell electrical lesion attenuates seizures and gliosis in chronic temporal lobe epilepsy rats

Epileptic Disorders, EarlyView.
Abstract Objective Temporal lobe epilepsy (TLE) is the most prevalent form of epilepsy. Prior research has indicated the involvement of the nucleus accumbens shell (NAcSh) in the process of epileptogenesis, thereby implying its potential as a therapeutic target for TLE.
Shuaishuai Xue, Peiyao Yi, Yangqi Mao, Zhengming Zhan, Yonghua Cai, Zibin Song, Kewan Wang, Kaijun Yang, Ye Song, Xingqin Wang, Hao Long   +10 more
wiley   +1 more source

Microglia and brain macrophages are differentially associated with tumor necrosis in glioblastoma: A link to tumor progression. [PDF]

Oncol Res
Loh C, Zheng Y, Alzoubi I, Alexander KL, Lee M, Cai WD, Song Y, McDonald K, Nowak AK, Banati RB, Graeber MB.   +10 more
europepmc   +1 more source

Ganglioside GD3 Immunochemistry does not Visualize Microglia but Astroglia.

, 2000
Yuko Yasuda, Takeshi Naito, Shinobu Watarai, Setsuya Fujita, Tadahisa Kitamura   +4 more
openalex   +2 more sources

Exploring biomarkers of neurodegeneration in epilepsy: Critical insights

Epileptic Disorders, EarlyView.
Abstract The advent of biofluid biomarkers for neurodegenerative disorders has precipitated a surge in recent evidence regarding their role in epilepsy. In this literature review, we examine the diagnostic, prognostic, and therapeutic potential of several biomarkers, including amyloid‐beta (Aβ) protein, total (t‐tau), phosphorylated tau (p‐tau) protein,
Rida Farhan, Syeda Amrah Hashmi, Jaideep Kapur, Anelyssa D'Abreu, Vineet Punia, Carol Manning, Vanessa L. Smith, Ifrah Zawar   +7 more
wiley   +1 more source

SIRPα modulates microglial efferocytosis and neuroinflammation following experimental subarachnoid hemorrhage via the SHP1/STAT6 axis. [PDF]

J Neuroinflammation
Zhang B, Zou Y, Tang Q, Yuan Z, Jiang K, Zhang Z, Chen S, Wu Q, Zhou X, Zhang X.   +9 more
europepmc   +1 more source

Asrij/OCIAD1 depletion reduces inflammatory microglial activation and ameliorates Aβ pathology in an Alzheimer's disease mouse model. [PDF]

J Neuroinflammation
Dongre P, Ramesh M, Govindaraju T, Inamdar MS.   +3 more
europepmc   +1 more source

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Tau‐targeting nanoparticles for treatment of Alzheimer's disease

Exploration, EarlyView.
Through review of comprehensive literature and research studies, it is found that tau‐targeting nanoparticles may posit beneficial applications to AD therapy. By targeting a key molecular mechanism known to propagate AD pathogenesis, tau‐targeting nanoparticles have the potential to facilitate tau tangle clearance, promote synaptic integrity, and ...
Shreya Pawar, Mohd Ahmar Rauf, Hosam Abdelhady, Arun K. Iyer   +3 more
wiley   +1 more source

Enhanced Blood‐Brain Barrier Penetrability of BACE1 SiRNA‐Loaded Prussian Blue Nanocomplexes for Alzheimer's Disease Synergy Therapy

Exploration, EarlyView.
BACE1 interfering RNA, metallothionein and ruthenium complexes ([Ru(bpy)2dppz]2+) were all loaded in prussian blue nanoparticles (PRM‐siRNA). PRM‐siRNA under near‐infrared light irradiation showed good photothermal effect and triggered instantaneous opening of blood‐brain barrier for enhanced drug delivery.
Xiaoyuan Ding, Yanyu Hu, Xiaotong Feng, Zekun Wang, Qile Song, Chunxue Dai, Bangjia Yang, Xiaoyan Fu, Dongdong Sun, Cundong Fan   +9 more
wiley   +1 more source

Drug delivery pathways to the central nervous system via the brain glymphatic system circumventing the blood‐brain barrier

Exploration, EarlyView.
The discovery of the glymphatic system has opened up a pathway for drug delivery to the brain by circumventing the blood‐brain barrier, which can effectively improve drug utilization. The methods of drug delivery through the glymphatic system include intrathecal injection, intranasal injection, and delivery through the meningeal lymphatic vessels.
Xiang Wang, Yue Yin, Huaijuan Zhou, Bowen Chi, Ling Guan, Pei Li, Jinhua Li, Yilong Wang   +7 more
wiley   +1 more source