Results 241 to 250 of about 388,044 (340)

A Programmable, 3D Neuron‐On‐Chip Platform Integrating Near Real‐Time Biosensing and Multiaxial Loading for Mechanobiological Injury Profiling

Advanced Science, EarlyView.
A programmable 3D Neuron‐Injury‐on‐a‐Chip platform integrates multiaxial mechanical loading with ultrasensitive electrochemical biosensing to decode neuronal responses in real time. By mimicking physiologically relevant extension–torsion forces, the system reveals load‐specific biomarker trajectories (T‐Tau, NFL), gene regulation, and apoptosis.
Sultan Khetani, Kar Wey Yong, Mawafag F. Alhasadi, Amir Hamedzadeh, Leila Shahsavari, Atefeh Rafiei, Kalvin Wu, Omakhowa Agbojo, Anupriya Singh, Kunal Karan, Salvatore Federico, Arindom Sen, Amir Sanati‐Nezhad   +12 more
wiley   +1 more source

Siponimod inhibits disease-associated microglia-T cell interactions in chronic experimental autoimmune encephalomyelitis. [PDF]

Acta Neuropathol Commun
Husseini L, Geladaris A, Steinleitner MCJ, Häusler D, Weber MS.   +4 more
europepmc   +1 more source

The Activation of Microglia and Astrocytes Participates in the Coexistence of Chronic Pain and Chronic Pruritus in the Allergic Contact Dermatitis

Wenzhang Dai, Zhenglang Zhang, Xu Tengyun, Anqi Luo, Zhenhui Luo, Kexin Chen, Wang Ranjing, Lai Ziwei, Junlin Wang, Hong Nie   +9 more
openalex   +1 more source

Anti-Inflammatory Effects of α-Galactosylceramide Analogs in Activated Microglia: Involvement of the p38 MAPK Signaling Pathway

, 2014
Yeon‐Hui Jeong, Yongju Kim, Heebum Song, Young Sun Chung, Seung Bum Park, Hee-Sun Kim   +5 more
openalex   +2 more sources

Microglia in neurodegeneration

Nature Neuroscience, 2018
S. Hickman, Saef Izzy, Pritha Sen, Liza M. Morsett, J. El Khoury   +4 more
semanticscholar   +1 more source

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

Microglia sensing of peripheral signals that bridge the brain and body. [PDF]

Mol Neurodegener
Young CE, Samuel MA.
europepmc   +1 more source

TNEA Regulates Hippocampal Oscillation by Improving Inhibitory Synaptic Plasticity to Ameliorates Cognitive Impairment in Alzheimer's Disease

Advanced Science, EarlyView.
TNEA improves cognition in 5xFAD mice by modulating parvalbumin‐positive interneurons in hippocampal CA1. TNEA enhances gamma oscillations during rest and theta power during novel object recognition, restoring excitation/inhibition balance. These findings support TNEA as a minimally invasive therapy for Alzheimer's disease.
Zhongzhao Guo, Hong Ni, Yu Lu, Zhengyu Cui, Yixing Wang, Zilu Zhu, Xinyu Wei, Chenyi Xia, Ming Xu, Lixia Du, Yufang Yang, Shi Shu, Ke Wang, Zhifei Wang, Chunlei Shan, Deheng Wang   +15 more
wiley   +1 more source

Activated microglial exosomes enhance α-Synuclein internalization and accelerate neurodegeneration in lewy body dementia. [PDF]

J Nanobiotechnology
Zhang M, You T, Guo M, Zhao Y, Shen W, Wang Y, Jiang Y, Dong Q, Yu J, Cui M, Zhao Y.   +10 more
europepmc   +1 more source

Nanogel Integrated Zwitterionic Injectable Hydrogel with Sequential Drug‐Releasing Capability for the Programmable Repair of Spinal Cord Injury

Advanced Science, EarlyView.
A novel drug‐loaded D/P‐g‐PSB nanogel‐incorporated hydrogel by the electrostatic attraction‐driven self‐assembling process. Sequential drug releasing property (melatonin is released first by physical diffusion, and then ibuprofen is released as the charge shielding effect and hydrogel degradation). This ion‐sensitive hydrogel platform with sequentially
Zhijian Wei, Susu Huang, Wencan Zhang, Jiayao Wen, Xiaolong Zhou, Wei He, Xiaoye Yang, Haifeng Wang, Guangxi Zhai, Bin Shi, Lin Jin, Dachuan Wang, Shiqing Feng, Lei Ye   +13 more
wiley   +1 more source