Results 241 to 250 of about 174,983 (281)

Engineered Exosome‐Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia

Exploration, EarlyView.
We identified a harmful immune cell type, p21+CD86+ microglia, driving post‐stroke inflammation and developed a targeted exosome‐based therapy (Que@micro‐Exo) to eliminate these cells. This innovative treatment reduced inflammation, alleviated brain damage, and improved recovery in stroke models, offering a promising strategy for stroke and other ...
Jialei Yang, Shipo Wu, Miao He
wiley   +1 more source

Exploring the Neuroprotective Role of Selenium: Implications and Perspectives for Central Nervous System Disorders

Exploration, EarlyView.
Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang, Ying Liu, Xiadong Zhu, Lizhen He, Tianfeng Chen   +4 more
wiley   +1 more source

High‐Precision, Low‐Threshold Neuromodulation With Ultraflexible Electrode Arrays for Brain‐to‐Brain Interfaces

Exploration, EarlyView.
Traditional neuromodulation using rigid electrodes has been limited by low precision, large stimulating currents, and the risk of tissue damage. In this work, we developed a biocompatible flexible electrode array that allows for both neural recording of spike firings and high‐precision, low‐threshold stimulation for neuromodulation.
Yifei Ye, Ye Tian, Haifeng Liu, Jiaxuan Liu, Cunkai Zhou, Chengjian Xu, Ting Zhou, Yanyan Nie, Yu Wu, Lunming Qin, Zhitao Zhou, Xiaoling Wei, Jianlong Zhao, Zhenyu Wang, Meng Li, Tiger H. Tao, Liuyang Sun   +16 more
wiley   +1 more source

Integrative network analysis reveals novel moderators of Aβ-Tau interaction in Alzheimer's disease. [PDF]

Alzheimers Res Ther
Kitani A, Matsui Y, Alzheimer’s Disease Neuroimaging Initiative.   +2 more
europepmc   +1 more source

Development and Application of Polyphenols in Food: A Comprehensive Review

Food Frontiers, EarlyView.
This review provides an in‐depth analysis of functional mechanisms and research trends in the application of polyphenol in food. ABSTRACT This review provides an in‐depth analysis of functional mechanisms and research trends in the application of polyphenol in food.
Yanpei Huang, Haiming Chen, Weijun Chen, Wenxue Chen, Qiuping Zhong, Jianfei Pei, Ming Zhang, Guido R. M. M. Haenen   +7 more
wiley   +1 more source

Voluntary exercise alleviates neural functional deficits in Parkinson's disease mice by inhibiting microglial ferroptosis via SLC7A11/ALOX12 axis. [PDF]

NPJ Parkinsons Dis
Xu J, He X, Li L, Zhang L, Li M, Mu Y, Yang X, Li S, Feng Y, Zuo Z, Xu Y, Hu X, Zheng H.   +12 more
europepmc   +1 more source

Organ‐on‐Chip: The Future of Nutrition Research in a One Health World

Food Frontiers, EarlyView.
Organ‐on‐chips offer a promising tool for evaluating food and feed safety. Organ‐on‐chips also present a scientifically robust and ethical alternative to animal studies. ABSTRACT The One Health approach emphasizes the interconnectedness of human, animal, and environmental health, recognizing that the health of each is interdependent and influenced by ...
Manuela Cassotta, Maria Elexpuru‐Zabaleta, Sandra Sumalla Cano, Yasmany Armas Diaz, Francesca Giampieri, Zou Xiaobo, Di Zhang, Giuseppe Grosso, Maurizio Battino   +8 more
wiley   +1 more source

Nicotinamide Riboside Mitigates Retinal Degeneration by Suppressing Damaged DNA-Stimulated Microglial Activation and STING-Mediated Pyroptosis. [PDF]

Invest Ophthalmol Vis Sci
Zhu S, Zhang L, Tong P, Chen J, Wang C, Wang Z, Liu J, Duan P, Jiang Q, Zhou Y, Tan G, Zhang X, Jiang B.   +12 more
europepmc   +1 more source

Microglia-derived CXCL2 induced neuronal ferroptosis via CXCR2/Jun axis in sepsis-associated encephalopathy. [PDF]

Front Immunol
Yang YS, Liang JW, Pei MQ, Fang YM, Sun ZD, He HF.   +5 more
europepmc   +1 more source