Results 21 to 30 of about 266,602 (329)
The role of microglia in Alzheimer's disease and progress of treatment
Ibrain, 2022 Microglia are permanent immune cells of the central nervous system. Microglia play an important role in the pathological process of Alzheimer's disease (AD). They are mainly involved in the uptake and clearance of amyloid‐β (Aβ), as well as the formation
Yi‐Huan Guan +6 more
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Metabolic Brain Disease, 2004 Microglia--the macrophage equivalent of the CNS--safeguards and supports neuronal functions. Threats to the CNS homeostasis can trigger a rapid transformation of these cells from a normally "resting" into alerted and "activated" states. Microglia primarily serves the tissue defence and protection when participating in mechanisms of innate and adaptive ...
van Rossum, Denise, Hanisch, Uwe-Karsten
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Cell Reports, 2019 Summary: Microglia have important remodeling functions in neurodevelopment, aging, and disease, with evidence for molecular diversity. However, the signaling pathways and environmental cues that drive diverse states of microglia are incompletely ...
Sarah R. Anderson +6 more
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Frontiers in Immunology, 2022 Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease worldwide, characterized by progressive neuron degeneration or loss due to excessive accumulation of β-amyloid (Aβ) peptides, formation of neurofibrillary tangles (NFTs), and ...
Yongle Cai +4 more
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Microglia-Derived Microvesicles Affect Microglia Phenotype in Glioma [PDF]
Frontiers in Cellular Neuroscience, 2019 Extracellular-released vesicles (EVs), such as microvesicles (MV) and exosomes (Exo) provide a new type of inter-cellular communication, directly transferring a ready to use box of information, consisting of proteins, lipids and nucleic acids. In the nervous system, EVs participate to neuron-glial cross-talk, a bidirectional communication important to ...
Alfonso Grimaldi +14 more
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Microglia morphophysiological diversity and its implications for the CNS
Frontiers in Immunology, 2022 Microglia are mononuclear phagocytes of mesodermal origin that migrate to the central nervous system (CNS) during the early stages of embryonic development.
A. Vidal-Itriago +9 more
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The semantics of microglia activation: neuroinflammation, homeostasis, and stress
Journal of Neuroinflammation, 2021 Microglia are emerging as critical regulators of neuronal function and behavior in nearly every area of neuroscience. Initial reports focused on classical immune functions of microglia in pathological contexts, however, immunological concepts from these ...
S. Woodburn, J. Bollinger, E. Wohleb
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Mediators of Inflammation, 2017 Microglia play an important role in mediating inflammatory processes in the central nervous system (CNS). Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglia-specific receptor and could decrease neuropathology in Alzheimer’s disease ...
Xiaobao Zhang +8 more
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Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy
Frontiers in Neuroscience, 2021 Microglia are the resident macrophages of the central nervous system (CNS) acting as the first line of defense in the brain by phagocytosing harmful pathogens and cellular debris. Microglia emerge from early erythromyeloid progenitors of the yolk sac and
L. Muzio, Alice Viotti, G. Martino
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Microbiology Spectrum, 2016 ABSTRACT The concept of the immunological privilege of the central nervous system (CNS) has had a profound influence on studies of interactions between the immune system and the CNS. At one time there was considerable debate as to whether there were any cells in the CNS of myeloid origin, but we now know that there are a number of populations
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