Results 21 to 30 of about 242,823 (354)
Journal of Experimental Medicine, 2019 The roles of microglia and ApoE in tauopathies, such as Alzheimer’s disease, remain elusive. In this issue, Shi et al. (https://doi.org/10.1084/jem.20190980) demonstrate that microglia-mediated innate immunity collaborates with ApoE to drive neurodegeneration and disease progression in a mouse model of tauopathy.
Shahrnaz Kemal, Robert Vassar
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Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
Translational Neurodegeneration, 2020 Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Microglia and astrocytes are key regulators of inflammatory responses in the central nervous system. The
H. S. Kwon, S. Koh
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Microglia regulate central nervous system myelin growth and integrity
Nature, 2022 Resident microglia in the central nervous system are identified as the specific macrophage population that regulates myelin growth and integrity. Myelin is required for the function of neuronal axons in the central nervous system, but the mechanisms that
N. McNamara +27 more
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Detection of Synaptic Proteins in Microglia by Flow Cytometry
Frontiers in Molecular Neuroscience, 2020 A growing body of evidence indicates that microglia actively remove synapses in vivo, thereby playing a key role in synaptic refinement and modulation of brain connectivity.
Simone Brioschi +12 more
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The role of microglia in Alzheimer's disease and progress of treatment
Ibrain, 2022 Microglia are permanent immune cells of the central nervous system. Microglia play an important role in the pathological process of Alzheimer's disease (AD). They are mainly involved in the uptake and clearance of amyloid‐β (Aβ), as well as the formation
Yi‐Huan Guan +6 more
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Journal of Inflammation Research, 2022 Microglia are tissue-resident macrophages of the central nervous system (CNS). In the CNS, microglia play an important role in the monitoring and intervention of synaptic and neuron-level activities.
Menglong Wang +5 more
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Microglia actively regulate the number of functional synapses. [PDF]
PLoS ONE, 2013 Microglia are the immunocompetent cells of the central nervous system. In the physiological setting, their highly motile processes continually survey the local brain parenchyma and transiently contact synaptic elements.
Kyungmin Ji +3 more
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Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration
Nature Neuroscience, 2022 Iron dysregulation has been implicated in multiple neurodegenerative diseases, including Parkinson’s disease (PD). Iron-loaded microglia are frequently found in affected brain regions, but how iron accumulation influences microglia physiology and ...
Sean K. Ryan +22 more
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The semantics of microglia activation: neuroinflammation, homeostasis, and stress
Journal of Neuroinflammation, 2021 Microglia are emerging as critical regulators of neuronal function and behavior in nearly every area of neuroscience. Initial reports focused on classical immune functions of microglia in pathological contexts, however, immunological concepts from these ...
S. Woodburn, J. Bollinger, E. Wohleb
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Neurobiology of Disease, 2023 Epilepsy is one of most common chronic neurological disorders, and the antiseizure medications developed by targeting neurocentric mechanisms have not effectively reduced the proportion of patients with drug-resistant epilepsy. Further exploration of the cellular or molecular mechanism of epilepsy is expected to provide new options for treatment ...
Cheng Yu, Xue-jun Deng, Da Xu
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