Results 21 to 30 of about 129,518 (327)

Microglia

Metabolic Brain Disease, 2004
Microglia--the macrophage equivalent of the CNS--safeguards and supports neuronal functions. Threats to the CNS homeostasis can trigger a rapid transformation of these cells from a normally "resting" into alerted and "activated" states. Microglia primarily serves the tissue defence and protection when participating in mechanisms of innate and adaptive ...
van Rossum, Denise, Hanisch, Uwe-Karsten
openaire   +4 more sources

Microglia in epilepsy

Neurobiology of Disease, 2023
Epilepsy is one of most common chronic neurological disorders, and the antiseizure medications developed by targeting neurocentric mechanisms have not effectively reduced the proportion of patients with drug-resistant epilepsy. Further exploration of the cellular or molecular mechanism of epilepsy is expected to provide new options for treatment ...
Cheng Yu, Xue-jun Deng, Da Xu
openaire   +3 more sources

Expression and Differential Responsiveness of Central Nervous System Glial Cell Populations to the Acute Phase Protein Serum Amyloid A [PDF]

, 2017
Acute-phase response is a systemic reaction to environmental/inflammatory insults and involves hepatic production of acute-phase proteins, including serum amyloid A (SAA). Extrahepatically, SAA immunoreactivity is found in axonal myelin sheaths of cortex
A Castellheim, A Ellis, AE Mullick, BK Lundholt, BM Schreiber, C Caltagirone, C Gabay, C Marinelli, C Nathan, C Nuccio De, C Rosin, C Solà, C Vaure, CM Uhlar, DB Noriega, DL Thiele, E Gruys, ES Wohleb, F Begum, F Caso, G Guillemin, GC Sellar, GS Getz, GW Duff, H Zheng, HJ Yu, I Hardardóttir, I Paterniti, I Paterniti, I Rajkovic, J Saura, JM Dopp, JS Liang, JT Guo, JW Jeong, J‐L Tchélingérian, K Selmaj, L Facci, L Probert, L Qin, L Sun, M Alhouayek, M Barbierato, M Bsibsi, M Buck De, M Cordaro, M Kopf, M Li, M Poljakovic, ME Hamby, MK McCoy, MS Kindy, N Castanon, N Cheng, N Marchi, P Matzinger, R Martini, RA Dal Canto, RL Meek, RM Ransohoff, S Amor, S Kim, S Lehnardt, S Sandri, S Spuler, SA Liddelow, SD Skaper, SD Skaper, SJ Crocker, SJ Hewett, SY Seong, T Kawamoto, T Miida, TC Theoharides, TF Chung, Y Kumon, Y Yu, YJ Jang   +77 more
core   +2 more sources

Potential of activated microglia as a source of dysregulated extracellular microRNAs contributing to neurodegeneration in amyotrophic lateral sclerosis [PDF]

, 2020
Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron degeneration in adults, and several mechanisms underlying the disease pathology have been proposed.
Christoforidou, Eleni, Hafezparast, Majid, Joilin, Greig   +2 more
core   +1 more source

Noninflammatory Changes of Microglia Are Sufficient to Cause Epilepsy. [PDF]

, 2018
Microglia are well known to play a critical role in maintaining brain homeostasis. However, their role in epileptogenesis has yet to be determined.
Adamo, Matthew A, Chang, Julia, Feustel, Paul, Gruenthal, Michael, Huang, Yunfei, Liao, Yuan, Mathern, Gary W, Mathur, Ramkumar, Mazurkiewicz, Joseph, Morgan, Shannon, Qian, Jiang, Ritaccio, Anthony L, Zhao, Xiaofeng, Zhu, Xinjun   +13 more
core   +6 more sources

CXCL16/CXCR6 axis drives microglia/macrophages phenotype in physiological conditions and plays a crucial role in glioma [PDF]

, 2018
Microglia are patrolling cells that sense changes in the brain microenvironment and respond acquiring distinct phenotypes that can be either beneficial or detrimental for brain homeostasis.
Antonangeli, Fabrizio, D'Alessandro, Giuseppina, Esposito, Vincenzo, Lepore, Francesca, Limatola, Cristina, Santoro, Antonio, Trettel, Flavia   +6 more
core   +1 more source

New insight on microglia activation in neurodegenerative diseases and therapeutics

Frontiers in Neuroscience, 2023
Microglia are immune cells within the central nervous system (CNS) closely linked to brain health and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.
Yucong Xu, Yucong Xu, Wei Gao, Wei Gao, Yingnan Sun, Minghua Wu, Minghua Wu   +6 more
doaj   +1 more source

The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function

Journal of Neuroinflammation, 2020
Background Microglia are essential to maintain cell homeostasis in the healthy brain and are activated after brain injury. Upon activation, microglia polarize towards different phenotypes.
Sabine Ulrike Vay, Lea Jessica Flitsch, Monika Rabenstein, Helena Monière, Igor Jakovcevski, Pavle Andjus, Dunja Bijelic, Stefan Blaschke, Helene Luise Walter, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger   +11 more
doaj   +1 more source

Comparing the Characteristics of Microglia Preparations Generated Using Different Human iPSC-Based Differentiation Methods to Model Neurodegenerative Diseases

ASN Neuro, 2022
As the resident immune cells of the healthy nervous system, homeostatic microglia can rapidly become activated in response to injury/disease. Dysregulated microglia activation is a hallmark of nervous system disorders including neurodegenerative diseases
Ye Man Tang, Nisha S. Pulimood, Stefano Stifani   +2 more
doaj   +1 more source

Advances in Visualizing Microglial Cells in Human Central Nervous System Tissue

Biomolecules, 2022
Neuroinflammation has recently been identified as a fundamentally important pathological process in most, if not all, CNS diseases. The main contributor to neuroinflammation is the microglia, which constitute the innate immune response system.
Christopher E. G. Uff, Karishma Patel, Charming Yeung, Ping K. Yip   +3 more
doaj   +1 more source