Results 21 to 30 of about 388,044 (340)

Expression and role of triggering receptor expressed on myeloid cells 2 in high glucose-treated microglia [PDF]

Jichu yixue yu linchuang
Objective To explore the expression of triggering receptor expressed on myeloid cells 2 (TREM2) in high-glucose microglia and to investigate the role of TREM2 in the proliferation, migration and phagocytosis of high-glucose microglia.
WANG Zhaohui, LIU Xiao, ZHOU Yue, WEI Xinyi, WANG Yue, LI Junfa, ZHAO Li
doaj   +1 more source

The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function

Journal of Neuroinflammation, 2020
Background Microglia are essential to maintain cell homeostasis in the healthy brain and are activated after brain injury. Upon activation, microglia polarize towards different phenotypes.
Sabine Ulrike Vay, Lea Jessica Flitsch, Monika Rabenstein, Helena Monière, Igor Jakovcevski, Pavle Andjus, Dunja Bijelic, Stefan Blaschke, Helene Luise Walter, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger   +11 more
doaj   +1 more source

The role of microglia in Alzheimer's disease and progress of treatment

Ibrain, 2022
Microglia are permanent immune cells of the central nervous system. Microglia play an important role in the pathological process of Alzheimer's disease (AD). They are mainly involved in the uptake and clearance of amyloid‐β (Aβ), as well as the formation
Yi‐Huan Guan, Ling‐Jing Zhang, Shi‐Ya Wang, Ya‐Dan Deng, Hong‐Su Zhou, Dong‐Qing Chen, Lan‐Chun Zhang   +6 more
doaj   +1 more source

Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration

Nature Neuroscience, 2022
Iron dysregulation has been implicated in multiple neurodegenerative diseases, including Parkinson’s disease (PD). Iron-loaded microglia are frequently found in affected brain regions, but how iron accumulation influences microglia physiology and ...
Sean K. Ryan, Matija Zelic, Yingnan Han, E. Teeple, Luoman Chen, M. Sadeghi, S. Shankara, Lilu Guo, Congmei Li, Fabrizio Pontarelli, Elizabeth H. Jensen, Ashley L. Comer, Dinesh Kumar, Mindy Zhang, Joseph Gans, Bailin Zhang, J. Proto, Jacqueline Saleh, J. Dodge, Virginia Savova, D. Rajpal, D. Ofengeim, Timothy R. Hammond   +22 more
semanticscholar   +1 more source

Microglia in the Neuroinflammatory Pathogenesis of Alzheimer’s Disease and Related Therapeutic Targets

Frontiers in Immunology, 2022
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease worldwide, characterized by progressive neuron degeneration or loss due to excessive accumulation of β-amyloid (Aβ) peptides, formation of neurofibrillary tangles (NFTs), and ...
Yongle Cai, Jingliu Liu, Bin Wang, Miao Sun, Hao Yang   +4 more
semanticscholar   +1 more source

Developmental Apoptosis Promotes a Disease-Related Gene Signature and Independence from CSF1R Signaling in Retinal Microglia

Cell Reports, 2019
Summary: Microglia have important remodeling functions in neurodevelopment, aging, and disease, with evidence for molecular diversity. However, the signaling pathways and environmental cues that drive diverse states of microglia are incompletely ...
Sarah R. Anderson, Jacqueline M. Roberts, Jianmin Zhang, Michael R. Steele, Cesar O. Romero, Alejandra Bosco, Monica L. Vetter   +6 more
doaj   +1 more source

CXCL16/CXCR6 axis drives microglia/macrophages phenotype in physiological conditions and plays a crucial role in glioma [PDF]

, 2018
Microglia are patrolling cells that sense changes in the brain microenvironment and respond acquiring distinct phenotypes that can be either beneficial or detrimental for brain homeostasis.
Antonangeli, Fabrizio, D'Alessandro, Giuseppina, Esposito, Vincenzo, Lepore, Francesca, Limatola, Cristina, Santoro, Antonio, Trettel, Flavia   +6 more
core   +1 more source

Microglia morphophysiological diversity and its implications for the CNS

Frontiers in Immunology, 2022
Microglia are mononuclear phagocytes of mesodermal origin that migrate to the central nervous system (CNS) during the early stages of embryonic development.
A. Vidal-Itriago, R. Radford, J. A. Aramideh, Cindy Maurel, Natalie M Scherer, E. Don, Albert J. Lee, R. Chung, M. Graeber, M. Morsch   +9 more
semanticscholar   +1 more source

NADPH oxidase as a therapeutic target in Alzheimer\u27s disease [PDF]

, 2008
At present, available treatments for Alzheimer\u27s disease (AD) are largely unable to halt disease progression. Microglia, the resident macrophages in the brain, are strongly implicated in the pathology and progressively degenerative nature of AD ...
Block, Michelle L
core   +4 more sources

Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases

Journal of Inflammation Research, 2022
Microglia are tissue-resident macrophages of the central nervous system (CNS). In the CNS, microglia play an important role in the monitoring and intervention of synaptic and neuron-level activities.
Menglong Wang, Wei Pan, Yao Xu, Jishou Zhang, J. Wan, Hong Jiang   +5 more
semanticscholar   +1 more source