Results 21 to 30 of about 334,601 (325)
Journal of Neuroinflammation, 2020 Background Microglia are essential to maintain cell homeostasis in the healthy brain and are activated after brain injury. Upon activation, microglia polarize towards different phenotypes.
Sabine Ulrike Vay +11 more
doaj +1 more source
CXCL16/CXCR6 axis drives microglia/macrophages phenotype in physiological conditions and plays a crucial role in glioma [PDF]
, 2018 Microglia are patrolling cells that sense changes in the brain microenvironment and respond acquiring distinct phenotypes that can be either beneficial or detrimental for brain homeostasis.
Antonangeli, Fabrizio +6 more
core +1 more source
Mediators of Inflammation, 2017 Microglia play an important role in mediating inflammatory processes in the central nervous system (CNS). Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglia-specific receptor and could decrease neuropathology in Alzheimer’s disease ...
Xiaobao Zhang +8 more
doaj +1 more source
Microglia actively regulate the number of functional synapses. [PDF]
PLoS ONE, 2013 Microglia are the immunocompetent cells of the central nervous system. In the physiological setting, their highly motile processes continually survey the local brain parenchyma and transiently contact synaptic elements.
Kyungmin Ji +3 more
doaj +1 more source
Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. [PDF]
, 2014 Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence.
A Castano +30 more
core +3 more sources
Microbiology Spectrum, 2016 ABSTRACT The concept of the immunological privilege of the central nervous system (CNS) has had a profound influence on studies of interactions between the immune system and the CNS. At one time there was considerable debate as to whether there were any cells in the CNS of myeloid origin, but we now know that there are a number of populations
openaire +4 more sources
NADPH oxidase as a therapeutic target in Alzheimer\u27s disease [PDF]
, 2008 At present, available treatments for Alzheimer\u27s disease (AD) are largely unable to halt disease progression. Microglia, the resident macrophages in the brain, are strongly implicated in the pathology and progressively degenerative nature of AD ...
Block, Michelle L
core +4 more sources
Noninflammatory Changes of Microglia Are Sufficient to Cause Epilepsy. [PDF]
, 2018 Microglia are well known to play a critical role in maintaining brain homeostasis. However, their role in epileptogenesis has yet to be determined.
Adamo, Matthew A +13 more
core +2 more sources
Microglia replacement by microglia transplantation (Mr MT) in the adult mouse brain
STAR Protocols, 2021 Summary: Mutations in microglia may cause brain disorders. Replacement of dysfunctional microglia by allogeneic wild-type microglia from bone marrow transplantation (Mr BMT) or peripheral blood can correct the gene deficiency at the brain-wide scale but ...
Zhen Xu, Bo Peng, Yanxia Rao
doaj +1 more source
Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease [PDF]
, 2018 The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role of peripheral inflammation induced by systemic lipopolysaccharide (LPS) administration in the MPTP-based model of Parkinson’s ...
Carrillo Jiménez, Alejandro +7 more
core +3 more sources