Results 21 to 30 of about 379,641 (387)

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

Translational Neurodegeneration, 2020
Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Microglia and astrocytes are key regulators of inflammatory responses in the central nervous system. The
H. S. Kwon, S. Koh
semanticscholar   +1 more source

Microglia regulate central nervous system myelin growth and integrity

Nature, 2022
Resident microglia in the central nervous system are identified as the specific macrophage population that regulates myelin growth and integrity. Myelin is required for the function of neuronal axons in the central nervous system, but the mechanisms that
N. McNamara, David A. D. Munro, Nadine Bestard-Cuche, Akiko Uyeda, Jeroen F. J. Bogie, A. Hoffmann, Rebecca K. Holloway, Irene Molina-Gonzalez, Katharine E. Askew, Stephen Mitchell, W. Mungall, Michael Dodds, Carsten Dittmayer, J. Moss, Jamie L. Rose, S. Szymkowiak, Lukas Amann, B. McColl, M. Prinz, T. Spires-Jones, W. Stenzel, K. Horsburgh, Jerome J. A. Hendriks, Clare Pridans, R. Muramatsu, Anna C. Williams, Josef Priller, V. Miron   +27 more
semanticscholar   +1 more source

Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases

Journal of Inflammation Research, 2022
Microglia are tissue-resident macrophages of the central nervous system (CNS). In the CNS, microglia play an important role in the monitoring and intervention of synaptic and neuron-level activities.
Menglong Wang, Wei Pan, Yao Xu, Jishou Zhang, J. Wan, Hong Jiang   +5 more
semanticscholar   +1 more source

Microglia in epilepsy

Neurobiology of Disease, 2023
Epilepsy is one of most common chronic neurological disorders, and the antiseizure medications developed by targeting neurocentric mechanisms have not effectively reduced the proportion of patients with drug-resistant epilepsy. Further exploration of the cellular or molecular mechanism of epilepsy is expected to provide new options for treatment ...
Cheng Yu, Xue-jun Deng, Da Xu
openaire   +3 more sources

The role of microglia in Alzheimer's disease and progress of treatment

Ibrain, 2022
Microglia are permanent immune cells of the central nervous system. Microglia play an important role in the pathological process of Alzheimer's disease (AD). They are mainly involved in the uptake and clearance of amyloid‐β (Aβ), as well as the formation
Yi‐Huan Guan, Ling‐Jing Zhang, Shi‐Ya Wang, Ya‐Dan Deng, Hong‐Su Zhou, Dong‐Qing Chen, Lan‐Chun Zhang   +6 more
doaj   +1 more source

Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits. [PDF]

, 2018
Microglia are the main immune component in the brain that can regulate neuronal health and synapse function. Exposure to cosmic radiation can cause long-term cognitive impairments in rodent models thereby presenting potential obstacles for astronauts ...
Campbell-Beachler, Mary, Chou, Austin, Feng, Xi, Grue, Katherine, Jones, Tamako, Krukowski, Karen, Nelson, Gregory, Paladini, Maria Serena, Riparip, Lara-Kirstie, Rosi, Susanna, Sacramento, Kristen   +10 more
core   +2 more sources

Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration

Nature Neuroscience, 2022
Iron dysregulation has been implicated in multiple neurodegenerative diseases, including Parkinson’s disease (PD). Iron-loaded microglia are frequently found in affected brain regions, but how iron accumulation influences microglia physiology and ...
Sean K. Ryan, Matija Zelic, Yingnan Han, E. Teeple, Luoman Chen, M. Sadeghi, S. Shankara, Lilu Guo, Congmei Li, Fabrizio Pontarelli, Elizabeth H. Jensen, Ashley L. Comer, Dinesh Kumar, Mindy Zhang, Joseph Gans, Bailin Zhang, J. Proto, Jacqueline Saleh, J. Dodge, Virginia Savova, D. Rajpal, D. Ofengeim, Timothy R. Hammond   +22 more
semanticscholar   +1 more source

Microglia

Metabolic Brain Disease, 2004
Microglia--the macrophage equivalent of the CNS--safeguards and supports neuronal functions. Threats to the CNS homeostasis can trigger a rapid transformation of these cells from a normally "resting" into alerted and "activated" states. Microglia primarily serves the tissue defence and protection when participating in mechanisms of innate and adaptive ...
van Rossum, Denise, Hanisch, Uwe-Karsten
openaire   +4 more sources

Microglia and neuroprotection [PDF]

Journal of Neurochemistry, 2015
AbstractMicroglia were first identified over a century ago, but our knowledge about their ontogeny and functions has significantly expanded only recently. Microglia colonize the central nervous system (CNS) in utero and play essential roles in brain development.
Zhihong Chen, Bruce D. Trapp
openaire   +3 more sources

Expression and role of triggering receptor expressed on myeloid cells 2 in high glucose-treated microglia [PDF]

Jichu yixue yu linchuang
Objective To explore the expression of triggering receptor expressed on myeloid cells 2 (TREM2) in high-glucose microglia and to investigate the role of TREM2 in the proliferation, migration and phagocytosis of high-glucose microglia.
WANG Zhaohui, LIU Xiao, ZHOU Yue, WEI Xinyi, WANG Yue, LI Junfa, ZHAO Li
doaj   +1 more source