Results 71 to 80 of about 334,601 (325)

TREM2-dependent effects on microglia in Alzheimer\u27s Disease [PDF]

, 2018
Alzheimer’s disease (AD) is a late-onset dementia characterized by the deposition of amyloid plaques and formation of neurofibrillary tangles (NFTs) which lead to neuronal loss and cognitive deficits.
Colonna, Marco, Ulland, Tyler K, Zhou, Yingyue   +2 more
core   +3 more sources

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB

Molecular Neurodegeneration
Background Microglia play crucial roles in maintaining neuronal homeostasis but have been implicated in contributing to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Benjamin E. Clarke, Oliver J. Ziff, Giulia Tyzack, Marija Petrić Howe, Yiran Wang, Pierre Klein, Claudia A. Smith, Cameron A. Hall, Adel Helmy, Michael Howell, Gavin Kelly, Rickie Patani   +11 more
doaj   +1 more source

Characterizing newly repopulated microglia in the adult mouse: impacts on animal behavior, cell morphology, and neuroinflammation.

PLoS ONE, 2015
Microglia are the primary immune cell in the brain and are postulated to play important roles outside of immunity. Administration of the dual colony-stimulating factor 1 receptor (CSF1R)/c-Kit kinase inhibitor, PLX3397, to adult mice results in the ...
Monica R P Elmore, Rafael J Lee, Brian L West, Kim N Green   +3 more
doaj   +1 more source

Diesel Exhaust Activates & Primes Microglia: Air Pollution, Neuroinflammation, & Regulation of Dopaminergic Neurotoxicity [PDF]

, 2011
BACKGROUND: Air pollution is linked to central nervous system disease, but the mechanisms responsible are poorly understood. OBJECTIVES: Here, we sought to address the brain-region-specific effects of diesel exhaust (DE) and key cellular mechanisms ...
Block, Michelle L, Duke, Laura, Johnson, Jo Anne, Kodavanti, Prasada, Kodavanti, Urmila, Levesque, Shannon, Lull, Melinda E., Stadler, Krisztian, Surace, Michael J., Taetzsch, Thomas, Wagner, Alison   +10 more
core   +1 more source

KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages [PDF]

, 2016
Among the strategies adopted by glioma to successfully invade the brain parenchyma is turning the infiltrating microglia/macrophages (M/MΦ) into allies, by shifting them toward an anti-inflammatory, pro-tumor phenotype.
Catalano, M, D'Alessandro, G, Di Angelantonio, S, Esposito, V, Esposito, V, Golia, MT, Grimaldi, A, Grössinger, EM, Limatola, C, Ragozzino, D, Santoro, A, Wulff, H   +11 more
core   +2 more sources

Heparin-binding epidermal growth factor and fibroblast growth factor 2 rescue Müller glia-derived progenitor cell formation in microglia- and macrophage-ablated chick retinas [PDF]

, 2023
Heithem M. El‐Hodiri, James R. Bentley, Alana Reske, Olivia B. Taylor, Isabella Palazzo, Warren A. Campbell, Nicklaus Halloy, Andy J. Fischer   +7 more
openalex   +1 more source

Neuroinflammation in GAD65 Antibody‐Associated Epilepsy Measured Using [18F]DPA‐714 PET/MRI

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The timing for initiating immunotherapy in patients with glutamic acid decarboxylase 65 (GAD65) antibody‐associated epilepsy is a challenge. We used the translocator protein radioligand [18F]DPA‐714 and PET to evaluate brain microglial activation.
Jingjing Chen, Yuying Zhang, Heyu Zhang, Jinming Zhang, Ningning Wang, Xintong Guo, Yicong Liu, Yue Liu, Xiangsong Zhang, Ziyi Chen, Guanzhong Ni   +10 more
wiley   +1 more source

A Custom Panel for Profiling Microglia Gene Expression

Cells
Despite being immune cells of the central nervous system (CNS), microglia contribute to CNS development, maturation, and homeostasis, and microglia dysfunction has been implicated in several neurological disorders.
Phani Sankar Potru, Natascha Vidovic, Susanne Wiemann, Tamara Russ, Marcel Trautmann, Björn Spittau   +5 more
doaj   +1 more source

Differences in microglia morphological profiles reflect divergent emotional temperaments: insights from a selective breeding model

Translational Psychiatry, 2022
Microglia play critical roles in healthy brain development and function, as well as the neuropathology underlying a range of brain diseases. Despite evidence for a role of microglia in affective regulation and mood disorders, little is known regarding ...
Pamela M. Maras, Elaine K. Hebda-Bauer, Megan H. Hagenauer, Kathryn L. Hilde, Peter Blandino, Stanley J. Watson, Huda Akil   +6 more
doaj   +1 more source