Results 71 to 80 of about 129,518 (327)

The plasticity of primary microglia and their multifaceted effects on endogenous neural stem cells in vitro and in vivo

Journal of Neuroinflammation, 2018
Background Microglia—the resident immune cells of the brain—are activated after brain lesions, e.g., cerebral ischemia, and polarize towards a classic “M1” pro-inflammatory or an alternative “M2” anti-inflammatory phenotype following characteristic ...
Sabine Ulrike Vay, Lea Jessica Flitsch, Monika Rabenstein, Rebecca Rogall, Stefan Blaschke, Judith Kleinhaus, Noémie Reinert, Annika Bach, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger   +10 more
doaj   +1 more source

Tools and Approaches for Studying Microglia In vivo

Frontiers in Immunology, 2020
Microglia are specialized resident macrophages of the central nervous system (CNS) that have important functions during neurodevelopment, homeostasis and disease.
Elisa Eme-Scolan, Elisa Eme-Scolan, Samantha J. Dando   +2 more
doaj   +1 more source

The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. [PDF]

, 2007
Perivascular microglia activation is a hallmark of inflammatory demyelination in multiple sclerosis (MS), but the mechanisms underlying microglia activation and specific strategies to attenuate their activation remain elusive.
Adams, Ryan A, Akassoglou, Katerina, Bauer, Jan, Degen, Jay L, Flick, Matthew J, Lassmann, Hans, Nuriel, Tal, Sikorski, Shoana L   +7 more
core  

An MRI assessment of mechanisms underlying lesion growth and shrinkage in multiple sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
By applying the tensor model, we analysed lesion orientation and the directionality of lesion expansion/contraction in multiple sclerosis. Each lesion is summarized as an ellipsoid, and the tensor model is applied to calculate lesion anisotropy. From the top to the bottom white matter atlas, surface‐in gradient segmentation and venous atlas used in the
Ermelinda De Meo, Ferran Prados Carrasco, J. William L. Brown, Alasdair J. Coles, Nick G. Cunniffe, Amy E. Jolly, Baris Kanber, Rebecca Samson, Frederik Barkhof, Declan Chard   +9 more
wiley   +1 more source

Characterizing newly repopulated microglia in the adult mouse: impacts on animal behavior, cell morphology, and neuroinflammation.

PLoS ONE, 2015
Microglia are the primary immune cell in the brain and are postulated to play important roles outside of immunity. Administration of the dual colony-stimulating factor 1 receptor (CSF1R)/c-Kit kinase inhibitor, PLX3397, to adult mice results in the ...
Monica R P Elmore, Rafael J Lee, Brian L West, Kim N Green   +3 more
doaj   +1 more source

Microglia in the aging brain: relevance to neurodegeneration

Molecular Neurodegeneration, 2010
Microglia cells are the brain counterpart of macrophages and function as the first defense in the brain. Although they are neuroprotective in the young brain, microglia cells may be primed to react abnormally to stimuli in the aged brain and to become ...
Ding Jian-Qing, Luo Xiao-Guang, Chen Sheng-Di   +2 more
doaj   +1 more source

Downregulation of PIK3IP1 in retinal microglia promotes retinal pathological neovascularization via PI3K-AKT pathway activation

Scientific Reports, 2023
Retinal pathological neovascularization involves endothelial cells, pericytes, photoreceptor cells, ganglion cells, and glial cells, whose roles remain unclear.
Lushu Chen, Yuan Cao, Yaming Shen, Huan Li, Rong Ye, Jin Yao   +5 more
doaj   +1 more source

Phase 1, First‐In‐Human, Single‐/Multiple‐Ascending Dose Study of Iluzanebart in Healthy Volunteers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of iluzanebart, a fully human monoclonal antibody TREM2 (triggering receptor expressed on myeloid cells 2) agonist, after single‐ (SAD) and multiple‐ascending‐dose (MAD) administration.
Andreas Meier, Spyros Papapetropoulos, Andrew Marsh, Kelly Neelon, David Stiles, Ryan O'Mara, Evan A. Thackaberry, Marco Colonna, Raj Rajagovindan   +8 more
wiley   +1 more source

Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB

Molecular Neurodegeneration
Background Microglia play crucial roles in maintaining neuronal homeostasis but have been implicated in contributing to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Benjamin E. Clarke, Oliver J. Ziff, Giulia Tyzack, Marija Petrić Howe, Yiran Wang, Pierre Klein, Claudia A. Smith, Cameron A. Hall, Adel Helmy, Michael Howell, Gavin Kelly, Rickie Patani   +11 more
doaj   +1 more source

Microglia replacement by bone marrow transplantation (Mr BMT) in the central nervous system of adult mice

STAR Protocols, 2021
Summary: Microglia are important immune cells in the central nervous system (CNS). Mutations in microglia may cause CNS disorders. Replacement of dysfunctional microglia with allogeneic wild-type microglia can correct the gene deficiency, thus treating ...
Zhen Xu, Xin Zhou, Bo Peng, Yanxia Rao
doaj