Results 91 to 100 of about 42,496 (156)

McVey M (2010) Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions

, 2020
Ku or DNA ligase 4-independent alternative end joining (alt-EJ) repair of DNA double-strand breaks (DSBs) frequently correlates with increased junctional microhomology. However, alt-EJ also produces junctions without microhomology (apparent blunt joins),
Amy Marie Yu, Mitch Mcvey
core  

The DNA helicase RTEL1 is involved in the repair of replicative DNA damage independently of the alternative end joining and the DNA–protein cross‐link repair pathways in Arabidopsis

The Plant Journal, Volume 126, Issue 3, May 2026.
SUMMARY Recent studies indicate that the Fe–S DNA helicase RTEL1 plays an important role in replicative DNA repair in plants. Since non‐homologous end joining (NHEJ) and DNA–protein cross‐link (DPC) repair also protect DNA replication in Arabidopsis, we set out to further define the interactions of RTEL1 and these pathways by analyzing double mutants ...
Lara Goldkuhle, Laura Lechner, Niklas Capdeville, Annika Dorn, Holger Puchta   +4 more
wiley   +1 more source

Generation of a recipient line for Rubisco engineering by multiplex genome editing in tobacco

The Plant Journal, Volume 126, Issue 4, May 2026.
SUMMARY Rubisco (ribulose 1,5‐bisphosphate carboxylase/oxygenase) is the primary CO2‐fixing enzyme on our planet. Its slow kinetics and poor discrimination between carbon dioxide and oxygen as substrates severely limit the efficiency of photosynthetic carbon fixation by plants.
Gonçalo E. da Silva, Stephan Obst, Pedro Carvalho, Joachim Forner, Stephanie Ruf, Nelson J. M. Saibo, Ralph Bock   +6 more
wiley   +1 more source

Disruption of Microhomology-mediated End-joining in Ewing Sarcoma

SUMMARY Ewing sarcoma (EwS) is a group of bone and soft tissue cancers in children and young adults. Since EwS cells have pronounced sensitivity to radiation and chemotherapy-induced DNA damage, the role of the oncoprotein, EWS-FLI1, in DNA repair is likely.
Shuhei Asada, Guangli Zhu, Jithma Prasad Abeykoon, Yutaro Tanaka, Huy Nguyen, Yuna Hirohashi, Divya R. Iyer, Nicholas William Ashton, Sirisha Mukkavalli, Martha Velazquez, Lige Jiang, Miles Del Busso, Judith Jebastin Thangaiah, Steven I. Robinson, Kalindi Parmar, Eliezer M. Van Allen, Riaz Gillani, Geoffrey I. Shapiro, Alan D. D’Andrea   +18 more
openaire   +2 more sources

Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells [PDF]

, 2013
Microhomology-mediated end joining (MMEJ) is a major pathway for Ku-independent alternative nonhomologous end joining, which contributes to chromosomal translocations and telomere fusions, but the underlying mechanism of MMEJ in mammalian cells is not ...
Truong, Lan N, Razavian, Niema, Wang, Hailong, Hwang, Patty Yi-Hwa, Berns, Michael W, Shi, Linda Z, He, Jing, Wu, Xiaohua, Li, Yongjiang   +8 more
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, Volume 20, Issue 4, Page 1061-1073, April 2026.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Pan‐3D Genome Analysis Reveals the Roles of Structural Variation in Chicken Chromatin Architectures, Domestication and Production Traits

Advanced Science, Volume 13, Issue 24, 27 April 2026.
This study firstly presents a comprehensive and high‐resolution pan‐3D genome resource in chicken. Our findings reveal the role of structural variations in 3D genome architectures, and how they influence the domestication process and production traits at the 3D genome level.
Zhen Zhou, Danfeng Cai, Changbin Zhao, Siyu Zhang, Jiahao Li, Zhaofeng Zhang, Shaofen Kong, Xin Yang, Xiaoli Zhou, Farhad Bordbar, Fayi Chen, Yaohuan Xu, Zhe Zhang, Lihong Gu, Zhenhui Li, Xiquan Zhang, Wen Luo, Jingting Shu, Bolin Cai, Qinghua Nie   +19 more
wiley   +1 more source

Defective Microhomology-Mediated End-joining in SMARCB1-Deficient Tumors

ABSTRACT Rhabdoid tumors (RTs) are highly aggressive cancers driven by biallelic mutation of SMARCB1, a core subunit of the BAF (SWI/SNF) complex. We found that SMARCB1-deficient tumors have a defect in the microhomology-mediated end-joining (MMEJ) pathway, and SMARCB1 is essential ...
Guangli Zhu, Shuhei Asada, Huy Nguyen, Yuna Hirohashi, Lifang Sun, Avneesh Saravanapavan, Sirisha Mukkavalli, Geoffrey I. Shapiro, Alan D. D’Andrea   +8 more
openaire   +3 more sources

Causative Role for a BRCA2 Germline Pathogenic Variant in External Auditory Canal Squamous Cell Carcinoma

Genes, Chromosomes and Cancer, Volume 65, Issue 4, April 2026.
ABSTRACT External auditory canal squamous cell carcinoma (EACSCC) is rare, affecting 1.6 in a million individuals. We report a case of EACSCC in a 66‐year‐old woman carrying a heterozygous BRCA2 germline pathogenic variant (GPV) (c.8537_8538del), with prior history of breast cancer.
José Camacho‐Valenzuela, Dylan Pelletier, Paz Polak, Lili Fu, Nancy Hamel, Carla Daniela Robles‐Espinoza, William D. Foulkes   +6 more
wiley   +1 more source

Non-homologous end joining often uses microhomology: implications for alternative end joining. [PDF]

, 2014
Artemis and PALF (also called APLF) appear to be among the primary nucleases involved in non-homologous end joining (NHEJ) and responsible for most nucleolytic end processing in NHEJ.
Watanabe, Go, Pannunzio, Nicholas, Lieber, Michael, Li, Sicong   +3 more
core   +1 more source