Results 101 to 110 of about 42,496 (156)

Stabilisation of Tomato Yellow Leaf Curl China Virus Infectious Clones Through Micro‐Homology Mediated End Joining

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2187-2200, April 2026.
ABSTRACT Tomato yellow leaf curl China virus (TYLCCNV) is a major agricultural pathogen and primary model for circular single‐stranded DNA (cssDNA) virus studies. The infectious clones of TYLCCNV and other cssDNA viruses are usually constructed as two tandem copies of the small viral genomes in Agrobacterium‐mediated T‐DNA vectors.
Anxiang Wang, Tian Meng, Ju Wang, Xiaomei Xu, Dan Li, Zhanqing Lv, Aiqi Yan, Mian Zhou, Bo Ding, Qiuying Yang   +9 more
wiley   +1 more source

Microhomology-mediated deletion and gene conversion in African trypanosomes. [PDF]

, 2010
Antigenic variation in African trypanosomes is induced by DNA double-strand breaks (DSBs). In these protozoan parasites, DSB repair (DSBR) is dominated by homologous recombination (HR) and microhomology-mediated end joining (MMEJ), while non-homologous ...
Glover, Lucy, Horn, David, Horn, David; id_orcid, Jun, Junho, Lucy Glover, David Horn, Junho Jun   +6 more
core   +1 more source

Microhomology-mediated end joining drives complex rearrangements and overexpression of MYC and PVT1 in multiple myeloma

, 2020
\ua92020 Ferrata Storti FoundationMYC is a widely acting transcription factor and its deregulation is a crucial event in many human cancers. MYC is important biologically and clinically in multiple myeloma, but the mechanisms underlying its dysregulation
Mikulasova A, Mavrommatis K, Bauer MA, Walker BA, Ashby C, Keats J, Rosenthal A, Tian E, Jackson GH, Yaccoby S, Davies FE, Ryan KR, Wardell CP, Qu P, Dent JA, Hoering A, Deshpande S, Morgan GJ, Tytarenko RG, Auclair D, Trotter M, Thakurta A   +21 more
core  

DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining.

, 2004
In human cells DNA double strand breaks (DSBs) can be repaired by the non-homologous end-joining (NHEJ) pathway. In a background of NHEJ deficiency, DSBs with mismatched ends can be joined by an error-prone mechanism involving joining between regions of ...
Diggle, CP, Kiltie, AE, Kiltie, Anne, Bentley, J, Harnden, P, Knowles, MA   +5 more
core   +1 more source

Distinct functions of PAXX and MRI during chromosomal end joining

iScience
Summary: A key step of canonical-nonhomologous end joining is synapsis of DNA double-strand break (DSB) ends, which appears to be mediated by both the DNA-PKcs dimer and XLF homodimer. We have examined this process by monitoring end joining (EJ) of blunt
Metztli Cisneros-Aguirre, Felicia Wednesday Lopezcolorado, Xiaoli Ping, Ruby Chen, Jeremy M. Stark   +4 more
doaj   +1 more source

Investigations of telomere maintenance in DNA damage response defective cells and telomerase in brain tumours

, 2005
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University, 17/03/2005.Telomeres are nucleoprotein complexes located at the end of chromosomes. They have an essential role in protecting chromosome ends.
Cabuy, Erik
core  

Comparative analysis of multiple DNA double-strand break repair pathways in CRISPR-mediated endogenous tagging

Communications Biology
CRISPR-mediated endogenous tagging is a powerful tool in biological research. Inhibiting the non-homologous end joining (NHEJ) pathway has been shown to improve the low efficiency of accurate knock-in via homology-directed repair (HDR).
Chiharu Tei, Shoji Hata, Akira Mabuchi, Shotaro Okuda, Kei K. Ito, Mariya Genova, Masamitsu Fukuyama, Shohei Yamamoto, Takumi Chinen, Atsushi Toyoda, Daiju Kitagawa   +10 more
doaj   +1 more source

Contribution of Microhomology to Genome Instability: Connection between DNA Repair and Replication Stress

, 2022
Microhomology-mediated end joining (MMEJ) is a highly mutagenic pathway to repair double-strand breaks (DSBs). MMEJ was thought to be a backup pathway of homologous recombination (HR) and canonical nonhomologous end joining (C-NHEJ). However, it attracts
Yuning Jiang, Jiang, Yuning
core   +1 more source

Polymerase theta repairs persistent G1-induced DNA breaks in S-phase during class switch recombination

Nature Communications
Non-homologous end joining (NHEJ) is the primary pathway for repairing G1 phase-induced DNA double-strand breaks (DSBs) during immunoglobulin heavy chain (Igh) class switch recombination (CSR) in B lymphocytes.
Timea Marton, Jinglong Wang, Amaury Vaysse, Wei Yu, Pierre-Henri Commere, Quentin Holleville, Tristan Espie-Caullet, Richard Frock, Ludovic Deriano   +8 more
doaj   +1 more source

ATM Kinase and BLM Helicase: A Regulator and Key Player in Microhomology-Mediated End Joining

, 2010
Microhomology-mediated end joining (MMEJ) is a class of DNA repair used to join DNA ends following a double-strand break (DSB). It represents an unfavorable and error-prone pathway because it results in deletion of nucleotides between microhomologies, as
Treister, Daniel
core