Results 121 to 130 of about 42,496 (156)

Rescue from pyridostatin-stabilized telomeric G-quadruplexes by DNA cleavage and microhomology-mediated end joining

G-quadruplexes are four-stranded nucleic acid structures that are formed by guanine rich sequences. They have been implicated to interfere with telomere maintenance, but their effects are not well understood at a molecular level.
Matmati, Samah, Lingner, Joachim, Rao, Satyajeet   +2 more
core   +1 more source

Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair

, 2010
Ig class-switch recombination (CSR) is a region-specific process that exchanges the constant Ig heavy-chain region and thus modifies an antibody's effector function.
Sven Kracker, Kohsuke Imai, Alain Fischer, Pauline Gardès, Hans D. Ochs, Anne H. Durandy   +5 more
core   +1 more source

Dynamic interplay of cNHEJ and MMEJ pathways of DNA double-strand break repair during embryonic development in zebrafish

Scientific Reports
Double strand breaks (DSBs) are the most deleterious DNA lesions as they frequently result in mutations when repaired by canonical non homologous end-joining (cNHEJ) and microhomology-mediated end-joining (MMEJ).
Mathieu Carrara, Anne-Laure Gaillard, Alice Brion, Evelyne Duvernois-Berthet, Carine Giovannangeli, Jean-Paul Concordet, Guillaume Pézeron   +6 more
doaj   +1 more source

Involvement of Illegitimate V(D)J Recombination or Microhomology-Mediated Nonhomologous End-Joining in the Formation of Intragenic Deletions of the Notch1 Gene in Mouse Thymic Lymphomas

, 2004
Deregulated V(D)J recombination-mediated chromosomal rearrangements are implicated in the etiology of B- and T-cell lymphomagenesis. We describe here three pathways for the formation of the 5' deletions of Notch1 gene in thymic lymphomas of wild-type or ...
勝部 孝則, 相澤 志郎, Aizawa, Shirou, 土居 雅広, Katsube, Takanori, 石井 洋子, 442410, 442411, 442412, Ukai, Hideki, 442413, 442414, 442415, 442416, 442417, Tsuji, Hideo, Doi, Masahiro, 442418, 442419, Ishii-Ohba, Hiroko, Ogiu, Toshiaki, 荻生 俊昭, 辻 秀雄, 442420, 442421, 442422, 442423, 442424, Hioki, Kyoji, 鵜飼 英樹   +29 more
core  

Microhomology-mediated end joining in fission yeast is repressed by pku70 and relies on genes involved in homologous recombination.

, 2007
Two DNA repair pathways are known to mediate DNA double-strand-break (DSB) repair: homologous recombination (HR) and nonhomologous end joining (NHEJ).
Decottignies, Anabelle
core   +1 more source

A role for ATM kinase activity and Mre11 in microhomology-mediated end-joining [PDF]

Cell Cycle, 2010
Anthony J. Davis, David J. Chen
openaire   +1 more source

Microhomology-Mediated End Joining as a Novel Mechanism Underlying Androgen Insensitivity Syndrome

Abstract Significance Statement This study identifies microhomology-mediated end joining (MMEJ) as a novel mutational mechanism underlying a pathogenic deletion in the androgen receptor gene in a patient with complete androgen insensitivity syndrome.
Juliana Moreira Marques, Raquel Martinez Ramos, Nathália Da Roz D’Alessandre, Gabriela Der Agopian Guardia, Ana Caroline de Freitas Afonso, Barbara Leitao Braga, Mariana Ferreira de Assis Funari, Mirian Yumie Nishi, Paula Fontes Asprino, Sorahia Domenice, Pedro Alexandre Favoretto Galante, Berenice Bilharinho Mendonca, Rafael Loch Batista   +12 more
openaire   +1 more source

Microhomology-mediated end joining is the predominant form of DNA repair in the mosquito Aedes aegypti with implications for gene editing, gene drive, and transgene removal. [PDF]

Nucleic Acids Res
Romanowski JS, Myles KM, Adelman ZN.
europepmc   +1 more source

The Role of BLM Helicase in Mammalian Microhomology-Mediated End Joining

, 2010
DNA repair pathways are important for the maintenance of genomic integrity and critical to the survival and health of an organism. In order to effectively eliminate damaged segments of DNA, DNA repair mechanisms require the separation of the two ...
Hossain, Aneesha
core  

The APE2 nuclease is essential for DNA double strand break repair by microhomology-mediated end-joining

, 2022
Fleury H, MacEachern MK, Stiefel CM, Anand R, Sempeck C, Nebenfuehr B, Dodd B, Taylor E, Dansoko D, Ortega R, Leung JW, Boulton SJ, Arnoult N.   +12 more
europepmc   +1 more source