Results 91 to 100 of about 28,349 (334)

Dopamine or opioid stimulation of nucleus accumbens similarly amplify cue‐triggered ‘wanting’ for reward: entire core and medial shell mapped as substrates for PIT enhancement [PDF]

, 2013
Pavlovian cues [conditioned stimulus ( CS +)] often trigger intense motivation to pursue and consume related reward [unconditioned stimulus ( UCS )]. But cues do not always trigger the same intensity of motivation.
Berridge, Kent C., Peciña, Susana
core   +1 more source

Activation of Spinal Astrocyte α2A Adrenoceptors Protects Against Sepsis‐Induced Heart Injury Through Inhibition of GABAergic Neuronal Necroptosis

Advanced Science, EarlyView.
The study in this paper found that activating the α2A receptors of astrocytes in the thoracic spinal cord can reduce the release of inflammatory factors, thereby decreasing the necroptosis of GABAergic neurons and consequently alleviating myocardial injury caused by sepsis.
Ruilin He, Bin Wu, Liuhu Han, Mingde Li, Wenli Guo, Jiajing Fu, Bin Mei, Eric R. Gross, Xuesheng Liu, Yao Lu   +9 more
wiley   +1 more source

A new experimental model of intrinsic denervation in ileum from wistar rats through intramural microinjections of benzalkonium chloride

Pesquisa Veterinária Brasileira, 2019
: Extensive literature is available about the intrinsic denervation of segments of the digestive tube through the application of CB in the serosa of the viscera.
Juliana O. Ribeiro, Marília G.P.A. Ferreira, Isabela C.S. Marques, Carolina Alvarenga, Andrigo B. Nardi, Sérgio B. Garcia, Gabriel Luiz Montanhim, Paola C. Moraes   +7 more
doaj   +1 more source

Treadmill running restores MDMA-mediated hyperthermia prevented by inhibition of the dorsomedial hypothalamus [PDF]

, 2015
The contribution of exercise to hyperthermia mediated by MDMA is not known. We recently showed that inhibiting the dorsomedial hypothalamus (DMH) attenuated spontaneous locomotion and hyperthermia and prevented deaths in rats given MDMA in a warm ...
Durant, Pamela J., Rusyniak, Daniel E., Zaretskaia, Maria V., Zaretsky, Dmitry V.   +3 more
core   +1 more source

Igfbp2 Downregulation in PVT‐CeA Glutamatergic Circuits Drives Neonatal Anesthesia‐Induced Fear Memory Deficits

Advanced Science, EarlyView.
Repeated neonatal sevoflurane exposure impairs adolescent fear memory through Igfbp2 downregulation in paraventricular thalamus‐central amygdala glutamatergic projections. Restoring Igfbp2 or activating this circuit rescues memory deficits, neuronal excitability, and spine density, identifying a precise molecular target for preventing anesthesia ...
Weiming Zhao, Ke Peng, Baojian Zhao, Xiaowen Meng, Gang Wang, Hanbing Xu, Li Deng, Xisheng Shan, Yichan Wang, Qiya Xu, Yanan Gao, Ruixia Weng, Hong Liu, Jin Tao, Huayue Liu, Shaoyong Song, Fuhai Ji   +16 more
wiley   +1 more source

Mesotherapy for Melasma – An Updated Review

Journal of Pharmacy and Bioallied Sciences
Mesotherapy is a popular novel therapeutic modality that delivers intradermal or subcutaneous microinjections of pharmaceutical compounds. Although this novel treatment method is used commonly in aesthetic dermatology, there is little information about ...
Kashikar Yash, Madke Bhushan, Singh Adarshlata, Meghe Soham, Rusia Kaveri   +4 more
doaj   +1 more source

Motor tics evoked by striatal disinhibition in the rat

Frontiers in Systems Neuroscience, 2013
Motor tics are sudden, brief, repetitive movements that constitute the main symptom of Tourette syndrome (TS). Multiple lines of evidence suggest the involvement of the cortico-basal ganglia system, and in particular the basal ganglia input structure ...
Maya eBronfeld, Dorin eYael, Katya eBelelovsky, Izhar eBar‐Gad   +3 more
doaj   +1 more source

Effects of hippocampal damage on reward threshold and response rate during self-stimulation of the ventral tegmental area in the rat [PDF]

, 1999
The main purpose of this study was to explore the role of the hippocampus in motivated behavior. Rats with bilateral excitotoxic lesions of the hippocampus and controls were trained to lever press for electrical stimulation of the ventral tegmental area.
Altman, Blaha, Brog, Campbell, Carlezon, Cuffel, Devenport, Douglas, Edmonds, Falkai, Fibiger, Fibiger, Fiorino, Fonnum, Fuller, Glickman, Groenewegen, Guy Mittleman, Hawkins, Hodos, Hodos, Jarrard, Jarrard, Kelley, Koob, Koob, Kovelman, Kramarcy, LeDuc, Liebman, Markou, Miliaressis, Mittleman, Olton, Phillips, Phillips, Ranaldi, Schaub, Schmelzeis, Sengstake, Sesack, Siegel, Stephen P. Kelley, Stewart, Sutherland, Taylor, Totterdell, Valenstein, Walass, Whishaw, Wilkinson, Witkin, Yang   +52 more
core   +1 more source

Therapeutic Repair of Sperm Quality Decline Caused by Polytetrafluoroethylene

Advanced Science, EarlyView.
Exposure to PTFE (teflon), a commonly used microplastic in non‐stick cookware, significantly reduces sperm quality in both humans and mice. Specifically, PTFE induces the disruption of sperm cytoskeleton and F‐actin assembly through targeting SKAP2 in haploid spermatid.
Shiming Gan, Shumin Zhou, Jiaming Zhou, Guanghui Zhang, Jingshou Chen, Rui Liu, Kuan Sun, Sisi Li, Wenjing Xiong, Yujiao Wen, Jianzhong Sheng, Yu Zhang, Jingchao Ren, Youjiang Li, Hefeng Huang, Chen Zhang   +15 more
wiley   +1 more source

Intracerebroventricular insulin injection acutely normalizes the augmented exercise pressor reflex in male rats with type 2 diabetes mellitus. [PDF]

J Physiol
Abstract figure legend The exercise pressor reflex (EPR), evoked by muscle contraction, is exaggerated in male rats with type 2 diabetes mellitus (T2DM). Cerebrospinal fluid insulin and phosphoinositide 3‐kinase in the nucleus tractus solitarius levels are normal in controls and low in T2DM rats, corresponding with normal and exaggerated EPR function ...
Estrada JA, Ishizawa R, Kim HK, Fukazawa A, Hori A, Hotta N, Iwamoto GA, Smith SA, Vongpatanasin W, Mizuno M.   +9 more
europepmc   +2 more sources