Results 121 to 130 of about 23,778 (281)
Advanced Science, EarlyView.Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling +17 more
wiley +1 more source
TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia
CNS Neuroscience &Therapeutics, EarlyView., 2023 Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi +19 more
wiley +1 more source
Advanced Science, EarlyView.Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan +11 more
wiley +1 more source
Advanced Science, EarlyView.The authors complement bovine pan‐SV with massive novel structural variations (SVs) identified through long‐read sequencing of 83 globally distributed cattle breeds. Repetitive sequence‐mediated SVs (rep‐SV) exhibit distinct dynamic patterns throughout cattle sub‐speciation and/or domestication processes, including uneven distribution between chr‐X and
Zhifan Guo +16 more
wiley +1 more source
Ion‐Pair‐Tuned Ionogels for Broad‐Range Linear Pressure Sensing
Advanced Science, EarlyView.Ionogels engineered through ion‐pair tuning extend the linear sensing range of capacitive pressure sensors. By balancing ionic mobility and polarizability within the polymer matrix, this approach mitigates dielectric saturation and maintains a stable pressure response across a broad operating range.
Hyeonseo Joo +11 more
wiley +1 more source
Advanced Science, EarlyView.Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters +12 more
wiley +1 more source
Unmasking of latent synaptic connections in the cortex of the rat, elicited by a facial nerve transection [PDF]
, 2001 Peripheral nerve injury elicits plastic changes in the cortex, resulting in reorganization of the somatotopic representation maps. These processes begin within minutes after nerve injury, and last for weeks.
Farkas, Tamás, Toldi, József
core
The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos
Advanced Science, EarlyView.Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan +8 more
wiley +1 more source
Bubbles Acting as Micro End‐Effectors for Dexterous Manipulation and Sensing in Aqueous Environment
Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.Inspired by bubbles, this article proposes a low‐cost method for multifunctional manipulation and sensing using microbubbles in aqueous environments. Bubbles are easily generated in situ, enabling the safe and adaptive handling of microobjects and sensing of microforces and surface textures.
Zichen Xu, Qingsong Xu
wiley +1 more source
Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.Herein, a patient‐mounted neuro optical coherence tomography system that integrates a 5 degrees‐of‐freedom skull‐mounted robot (Skullbot) with a 0.6 mm neuroendoscope for targeted, minimally invasive deep brain imaging, is developed. The system offers high‐resolution imaging with precise deployment, demonstrated through successful tumor imaging in a ...
Chao Xu +7 more
wiley +1 more source