A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59®-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration [PDF]
, 2014 Strategies to optimize responses to seasonal influenza vaccination in older adults include the use of adjuvants, higher antigen doses, and intradermal delivery.
Castellino, Flora +9 more
core +1 more source
Bioinorganic Chemistry and Applications, 2022 The demand for drug delivery systems (DDS) to treat Parkinson’s disease (PD) is still high, and microneedle (MN) assisted transdermal DDS offers enormous potential.
Delna Joy +10 more
doaj +1 more source
Pain-free oral delivery of biologic drugs using intestinal peristalsis–actuated microneedle robots
Science AdvancesBiologic drugs hold immense promise for medical treatments, but their oral delivery remains a daunting challenge due to the harsh digestive environment and restricted gastrointestinal absorption.
Xize Gao +4 more
semanticscholar +1 more source
Investigation of Plasma Treatment on Micro-Injection Moulded Microneedle for Drug Delivery [PDF]
, 2015 YesPlasma technology has been widely used to increase the surface energy of the polymer surfaces for many industrial applications; in particular to increase in wettability.
Grant, Colin A. +6 more
core +2 more sources
Microneedle-Based Natural Polysaccharide for Drug Delivery Systems (DDS): Progress and Challenges
Pharmaceuticals, 2022 In this focused progress review, the most widely accepted methods of transdermal drug delivery are hypodermic needles, transdermal patches and topical creams.
Fouad Damiri +12 more
semanticscholar +1 more source
Microneedle-based drug and vaccine delivery via nanoporous microneedle arrays [PDF]
Drug Delivery and Translational Research, 2015 In the literature, several types of microneedles have been extensively described. However, porous microneedle arrays only received minimal attention. Hence, only little is known about drug delivery via these microneedles. However, porous microneedle arrays may have potential for future microneedle-based drug and vaccine delivery and could be a valuable
Maaden, K. van der +5 more
openaire +5 more sources
Suprachoroidal and Subretinal Injections of AAV Using Transscleral Microneedles for Retinal Gene Delivery in Nonhuman Primates. [PDF]
, 2020 Retinal gene therapy using adeno-associated viruses (AAVs) is constrained by the mode of viral vector delivery. Intravitreal AAV injections are impeded by the internal limiting membrane barrier, while subretinal injections require invasive surgery and ...
Chung, Sook Hyun +7 more
core
Snake fang-inspired stamping patch for transdermal delivery of liquid formulations [PDF]
, 2019 A flexible microneedle patch that can transdermally deliver liquid-phase therapeutics would enable direct use of existing, approved drugs and vaccines, which are mostly in liquid form, without the need for additional drug solidification, efficacy ...
Ahn, Yujin +16 more
core +1 more source
Advanced Functional Materials, EarlyView.A hybrid‐nested microneedle/cryogel scaffold (MQW‐CMg‐MOF) is designed for efficient biofilm removal and accelerated healing of diabetic wounds. The scaffold shows substantial biofilm removal in vitro and in a preclinical diabetic swine biofilm‐infected wound model compared to the control.
Syed Muntazir Andrabi +11 more
wiley +1 more source
Chinese Medicine and Natural ProductsObjective Our objective was to assess the effectiveness and safety of microneedle by comparing microneedle plus 5% topical minoxidil treatment and microneedle alone to 5% topical minoxidil.
Chunyan Xu +3 more
doaj +1 more source